Mouse Cd44 activation kit by CRISPRa

CAT#: GA200626

Cd44 CRISPRa kit - CRISPR gene activation of mouse CD44 antigen



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

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经常一起买 (1)
CD44 (Pgp, Ly-24,Hyaluronan Receptor), rat anti mouse, clone IM7.8.1
    • 200 ug

CNY 6,450.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Cd44
Locus ID 12505
Kit Components

GA200626G1, Cd44 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA200626G2, Cd44 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA200626G3, Cd44 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001039150, NM_001039151, NM_001177785, NM_001177786, NM_001177787, NM_009851
Synonyms AU023126; AW121933; AW146109; HERMES; Ly-24; Pgp-1
Summary Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:8343954, PubMed:25065622). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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