United States
Germany
Japan
United Kingdom
China
Angiotensin II Type 2 Receptor (AGTR2) (NM_000686) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC223317L1V
- LentiORF®
-
Lenti ORF particles, AGTR2 (Myc-DDK tagged) - Human angiotensin II receptor, type 2 (AGTR2), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
货期*
详询
规格
| Cited in 2 publications. |
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | Angiotensin II Type 2 Receptor (AGTR2) (NM_000686) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | AT2; ATGR2; MRX88 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_000686 |
| ORF Size | 1089 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC223317).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_000686.3 |
| RefSeq Size | 2448 bp |
| RefSeq ORF | 1092 bp |
| Locus ID | 186 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction, Renin-angiotensin system |
| MW | 41 kDa |
| Gene Summary | The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Intracrine action of angiotensin II in mesangial cells: subcellular distribution of angiotensin II receptor subtypes AT1 and AT2.
,null,
Molecular and cellular biochemistry
,PubMed ID 29455433
[AGTR2]
|
|
Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation
,null,
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
,PubMed ID 26330760
[AGTR2]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
其它Angiotensin II Type 2 Receptor产品
Customer
Reviews
Loading...
