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COQ6 (NM_182480) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC217898L3V
- LentiORF®
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Lenti ORF particles, COQ6 (Myc-DDK tagged) - Human coenzyme Q6 homolog, monooxygenase (S. cerevisiae) (COQ6), nuclear gene encoding mitochondrial protein, transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,265.00
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Specifications
| Product Data | |
| Product Name | COQ6 (NM_182480) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CGI-10; CGI10; COQ10D6 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_182480 |
| ORF Size | 1329 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC217898).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_182480.1, NP_872286.2 |
| RefSeq Size | 1553 bp |
| RefSeq ORF | 1332 bp |
| Locus ID | 51004 |
| Protein Families | Druggable Genome |
| Protein Pathways | Metabolic pathways, Ubiquinone and other terpenoid-quinone biosynthesis |
| MW | 43 kDa |
| Gene Summary | The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012] |
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