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CBL (NM_005188) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC214069L2V
- LentiORF®
-
Lenti ORF particles, CBL (mGFP-tagged) - Human Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL), 200ul, >10^7 TU/mL
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CNY 9,975.00
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| Product Data | |
| Product Name | CBL (NM_005188) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | C-CBL; CBL2; FRA11B; NSLL; RNF55 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_005188 |
| ORF Size | 2718 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC214069).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_005188.2 |
| RefSeq Size | 11242 bp |
| RefSeq ORF | 2721 bp |
| Locus ID | 867 |
| Domains | UBA, RING, Cbl_N |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis |
| MW | 99.5 kDa |
| Gene Summary | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
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