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Ikaros (IKZF1) (NM_006060) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC213207L1V
- LentiORF®
-
Lenti ORF particles, IKZF1 (Myc-DDK tagged) - Human IKAROS family zinc finger 1 (Ikaros) (IKZF1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 9,690.00
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Specifications
| Product Data | |
| Product Name | Ikaros (IKZF1) (NM_006060) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CVID13; Hs.54452; IK1; IKAROS; LyF-1; LYF1; PPP1R92; PRO0758; ZNFN1A1 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_006060 |
| ORF Size | 1557 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC213207).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_006060.2 |
| RefSeq Size | 3962 bp |
| RefSeq ORF | 1560 bp |
| Locus ID | 10320 |
| Domains | zf-C2H2 |
| Protein Families | Druggable Genome, Transcription Factors |
| MW | 57.3 kDa |
| Gene Summary | This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] |
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