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Neutrophil Elastase (ELANE) (NM_001972) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC210399L4V
- LentiORF®
-
Lenti ORF particles, ELANE (mGFP-tagged) - Human elastase, neutrophil expressed (ELANE), 200ul, >10^7 TU/mL
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CNY 9,120.00
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Specifications
| Product Data | |
| Product Name | Neutrophil Elastase (ELANE) (NM_001972) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ELA2; GE; HLE; HNE; NE; PMN-E; SCN1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001972 |
| ORF Size | 801 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC210399).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001972.2 |
| RefSeq Size | 938 bp |
| RefSeq ORF | 804 bp |
| Locus ID | 1991 |
| Domains | Tryp_SPc |
| Protein Families | Protease, Transmembrane |
| Protein Pathways | Systemic lupus erythematosus |
| MW | 28.5 kDa |
| Gene Summary | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016] |
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