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TMPRSS2 (NM_005656) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC208677L2V
- LentiORF®
-
Lenti ORF particles, TMPRSS2 (mGFP-tagged) - Human transmembrane protease, serine 2 (TMPRSS2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 9,975.00
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| Product Data | |
| Product Name | TMPRSS2 (NM_005656) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | PRSS10 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_005656 |
| ORF Size | 1476 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC208677).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_005656.2 |
| RefSeq Size | 3212 bp |
| RefSeq ORF | 1479 bp |
| Locus ID | 7113 |
| Domains | SR, Tryp_SPc, ldl_recept_a |
| Protein Families | Druggable Genome, Protease, Secreted Protein, Transmembrane |
| MW | 53.9 kDa |
| Gene Summary | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] |
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