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INPP5E (NM_019892) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC206984L1V
- LentiORF®
-
Lenti ORF particles, INPP5E (Myc-DDK tagged) - Human inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), 200ul, >10^7 TU/mL
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CNY 8,930.00
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规格
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Specifications
| Product Data | |
| Product Name | INPP5E (NM_019892) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CORS1; CPD4; JBTS1; MORMS; pharbin; PPI5PIV |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_019892 |
| ORF Size | 1932 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC206984).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_019892.3 |
| RefSeq Size | 3440 bp |
| RefSeq ORF | 1935 bp |
| Locus ID | 56623 |
| Protein Families | Druggable Genome |
| Protein Pathways | Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system |
| MW | 70 kDa |
| Gene Summary | The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
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