TAB2 (NM_001292034) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CHTD2; MAP3K7IP2; TAB-2
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001292034, the custom clone sequence may differ by one or more nucleotides ATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGTAC CTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTC TCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGT CTACGCAATCACATGACTTCTCTCAACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAG GAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTC CAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTT GGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAA CATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGAC TGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGA AATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTG GCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGAC TACTTGTCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACC TCTCATGTCTACATGCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCT CACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGA AATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGC ACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCC CAAATACGGATGAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGA TGAACAGGTCATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGG AACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAG GCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTAC AGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTT CTTAATCATCCTGATCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATG TGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTT GGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAA TTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATAT CCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGA CTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAAC TTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAA CACCAAAGACTCAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAA CCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001292034
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001292034.2, NP_001278963.1
RefSeq Size	4171 bp
RefSeq ORF	2082 bp
Locus ID	23118
UniProt ID	Q9NYJ8
Protein Families	Druggable Genome
Protein Pathways	MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
Gene Summary	The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

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