CTNNA2 (NM_001282599) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CAP-R; CAPR; CDCBM9; CT114; CTNR
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC336879 representing NM_001282599. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGATGGATGGAGAAGGCCACTCCAGTCAGTAGGCAAAGTCTGTGAAAAAAATATGAAGACTTCTGAG ATGCATACCATGTCTGGAGCACAGACTGGAAGGAAAGAAAAAGGAGATCCTCTCAACATTGCGATTGAT AAGATGACTAAGAAAACAAGAGATCTAAGGAGACAGCTTCGGAAAGCAGTGATGGATCACATATCTGAC TCTTTCCTGGAAACCAATGTTCCTTTGCTAGTTCTCATTGAGGCTGCAAAGAGCGGAAATGAAAAGGAA GTGAAAGAATATGCCCAAGTTTTCCGTGAGCATGCCAACAAACTGGTAGAGGTTGCCAATTTGGCCTGT TCCATCTCCAACAATGAAGAAGGGGTGAAATTAGTTCGGATGGCAGCCACCCAGATTGACAGCCTGTGT CCCCAGGTCATCAATGCCGCTCTGACACTGGCTGCCCGGCCACAGAGCAAAGTTGCTCAGGATAACATG GACGTCTTCAAAGACCAGTGGGAGAAGCAGGTCCGAGTGTTGACAGAGGCCGTGGATGACATCACCTCA GTGGATGACTTCCTCTCTGTCTCAGAAAATCACATCTTGGAGGATGTGAACAAGTGTGTGATAGCCCTC CAAGAGGGCGATGTGGACACTCTGGACCGGACTGCAGGGGCCATCAGGGGCCGGGCAGCTCGAGTCATA CACATCATCAATGCTGAGATGGAGAACTATGAAGCTGGGGTTTATACTGAGAAGGTGTTGGAAGCTACA AAATTGCTTTCTGAAACAGTGATGCCACGCTTCGCTGAACAAGTAGAGGTTGCCATTGAAGCCCTGAGT GCCAACGTTCCTCAACCGTTTGAGGAGAATGAGTTCATCGATGCCTCTCGCCTGGTGTATGATGGCGTT CGGGACATCAGAAAGGCTGTGCTGATGATCAGGACCCCAGAAGAACTAGAGGATGATTCTGACTTTGAG CAGGAAGATTATGATGTGCGTAGCAGGACAAGTGTTCAGACTGAGGATGACCAGCTCATTGCAGGGCAG AGCGCACGGGCCATCATGGCGCAACTACCGCAGGAGGAGAAGGCAAAAATAGCTGAGCAGGTGGAGATA TTCCATCAAGAGAAAAGCAAGCTGGATGCAGAAGTGGCCAAATGGGACGACAGCGGCAATGATATCATT GTACTGGCCAAGCAGATGTGTATGATCATGATGGAAATGACAGACTTCACAAGAGGCAAAGGCCCATTG AAAAATACATCTGATGTCATTAATGCTGCCAAGAAAATTGCCGAAGCAGGTTCTCGAATGGACAAATTA GCTCGTGCTGTGGCTGATCAGTGTCCTGATTCAGCATGTAAGCAGGATTTATTAGCCTACCTTCAACGA ATTGCCTTGTATTGCCATCAGCTTAATATCTGCAGCAAGGTGAAGGCAGAAGTGCAGAATCTGGGAGGA GAGCTCATTGTGTCAGGGCTGGACAGTGCCACATCGCTTATCCAGGCAGCTAAAAACCTGATGAATGCT GTTGTCCTCACGGTGAAAGCATCCTATGTGGCCTCAACCAAATACCAGAAGGTCTATGGGACAGCAGCT GTCAACTCACCTGTTGTGTCTTGGAAGATGAAGGCTCCAGAGAAGAAGCCCCTTGTGAAGAGAGAAAAG CCTGAAGAATTCCAGACACGAGTTCGACGAGGTTCTCAGAAGAAACACATTTCGCCTGTACAGGCTTTA AGTGAATTCAAAGCAATGGATTCCTTCTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_001282599
Insert Size	1755 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001282599.1
RefSeq Size	2946 bp
RefSeq ORF	1755 bp
Locus ID	1496
UniProt ID	P26232
Protein Families	Druggable Genome
Protein Pathways	Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Endometrial cancer, Leukocyte transendothelial migration, Pathways in cancer, Tight junction
MW	65.1 kDa
Gene Summary	May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences compared to variant 3. These differences include translation initiation at an alternate AUG start codon. The resulting isoform (5) has a shorter and distinct N-terminus and lacks an internal segment near the C-terminus compared to isoform 3.

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