ERBIN (NM_001253701) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ERBB2IP; HEL-S-78; LAP2
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332219 representing NM_001253701. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGACTACAAAACGAAGTTTGTTTGTGCGGTTGGTACCATGTCGCTGTCTACGAGGGGAAGAGGAGACT GTCACTACTCTTGATTATTCTCATTGCAGCTTAGAACAAGTTCCGAAAGAGATTTTTACTTTTGAAAAA ACCTTGGAGGAACTCTATTTAGATGCTAATCAGATTGAAGAGCTTCCAAAGCAACTTTTTAACTGTCAG TCTTTACACAAACTGAGTTTGCCAGACAATGATTTAACAACGTTACCAGCATCCATTGCAAACCTTATT AATCTCAGGGAACTGGATGTCAGCAAGAATGGAATACAGGAGTTTCCAGAAAATATAAAAAATTGTAAA GTTTTGACAATTGTGGAGGCCAGTGTAAACCCTATTTCCAAGCTCCCTGATGGATTTTCTCAGCTGTTA AACCTAACCCAGTTGTATCTGAATGATGCTTTTCTTGAGTTCTTGCCAGCAAATTTTGGCAGATTAACT AAACTCCAAATATTAGAGCTTAGAGAAAACCAGTTAAAAATGTTGCCTAAAACTATGAATAGACTGACC CAGCTGGAAAGACTGGATTTGGGAAGTAACGAATTCACGGAAGTGCCTGAAGTACTTGAGCAACTAAGT GGATTGAAAGAGTTTTGGATGGATGCTAATAGACTGACTTTTATTCCAGGGTTTATTGGTAGTTTGAAA CAGCTCACATATTTGGATGTTTCTAAAAATAATATTGAAATGGTTGAAGAAGGAATTTCAACATGTGAA AACCTTCAAGACCTCCTATTATCAAGCAATTCACTTCAGCAGCTTCCTGAGACTATTGGTTCGTTGAAG AATATAACAACGCTTAAAATAGATGAAAACCAGTTAATGTATCTGCCAGACTCTATAGGAGGGTTAATA TCAGTAGAAGAACTGGATTGTAGTTTCAATGAAGTTGAAGCTTTGCCTTCATCTATTGGGCAGCTTACT AACTTAAGAACTTTTGCTGCTGATCATAATTACTTACAGCAGTTGCCCCCAGAGATTGGAAGCTGGAAA AATATAACTGTGCTGTTTCTCCATTCCAATAAACTTGAGACACTTCCAGAGGAAATGGGTGATATGCAA AAATTAAAAGTCATTAATTTAAGTGATAATAGATTAAAGAATTTACCCTTTAGCTTTACAAAGCTACAG CAATTGACAGCTATGTGGCTCTCAGATAATCAGTCCAAACCCCTGATACCTCTTCAAAAAGAAACTGAT TCAGAGACCCAGAAAATGGTGCTTACCAACTACATGTTCCCTCAACAGCCAAGGACTGAGGATGTTATG TTTATATCAGATAATGAAAGTTTTAACCCTTCATTGTGGGAGGAACAGAGGAAACAGCGGGCTCAAGTT GCATTTGAATGTGATGAAGACAAAGATGAAAGGGAGGCACCTCCCAGGGAGGGAAATTTAAAAAGATAT CCAACACCATACCCAGATGAGCTTAAGAATATGGTCAAAACTGTTCAAACCATTGTACATAGATTAAAA GATGAAGAGACCAATGAAGACTCAGGAAGAGATTTGAAACCACATGAAGATCAACAAGATATAAATAAA GATACCTCAGAAAGTACTACTACAGTAAAAAGCAAAGTTGATGAAAGAGAAAAATATATGATAGGAAAC TCTGTACAGAAGATCAGTGAACCTGAAGCTGAGATTAGTCCTGGGAGTTTACCAGTGACTGCAAATATG AAAGCCTCTGAGAACTTGAAGCATATTGTTAACCATGATGATGTTTTTGAGGAATCTGAAGAACTTTCT TCTGATGAAGAGATGAAAATGGCGGAGATGCGACCACCATTAATTGAAACCTCTATTAACCAGCCAAAA GTCGTAGCACTTAGTAATAACAAAAAAGATGATACAAAGGAAACAGATTCTTTATCAGATGAAGTTACA CACAATAGCAATCAGAATAACAGCAATTGTTCTTCTCCATCTCGGATGTCTGATTCAGTTTCTCTTAAT ACTGATAGTAGTCAAGACACCTCACTCTGCTCTCCAGTGAAACAAACTCATATTGATATTAATTCCAAA ATCAGGCAAGAAGATGAAAATTTTAACAGCCTTTTACAAAATGGAGATATTTTAAACAGTTCAACAGAG GAAAAGTTCAAAGCTCATGATAAAAAAGATTTTAACTTACCTGAATATGATTTGAATGTTGAAGAGCGA TTAGTTCTAATTGAGAAAAGTGTTGACTCAACAGCCACAGCTGATGACACTCACAAATTAGATCATATC AATATGAATCTTAATAAACTTATAACTAATGATACATTTCAACCAGAGATCATGGAAAGATCAAAAACA CAGGATATTGTGCTTGGAACAAGCTTTTTAAGCATTAATTCTAAAGAGGAAACTGAGCACTTGGAAAAT GGAAACAAGTATCCTAATTTGGAATCCGTAAATAAGGTAAATGGACATTCTGAGGAAACTTCCCAGTCT CCTAATAGGACTGAACCACATGACAGTGATTGTTCTGTTGACTTAGGTATTTCCAAAAGCACTGAAGAT CTCTCCCCTCAGAAAAGTGGTCCAGTTGGATCTGTTGTGAAATCTCATAGCATAACTAATATGGAGATT GGAGGGCTAAAAATCTATGATATTCTTAGTGATAATGGACCTCAGCAGCCAAGTACAACCGTTAAAATC ACATCTGCTGTTGATGGAAAAAATATAGTCAGGAGCAAGTCTGCCACACTGTTGTATGATCAACCATTG CAGGTATTTACTGGTTCTTCCTCATCTTCTGATTTAATATCAGGAACAAAGGCAATTTTCAAGTTTGAT TCAAATCATAATCCCGAAGAGCCAAATATAATAAGAGGCCCCACAAGTGGCCCACAATCTGCACCTCAA ATATATGGTCCTCCACAGTATAATATCCAATACAGTAGCAGTGCTGCAGTCAAAGACACTTTGTGGCAC TCCAAACAAAATCCCCAAATAGACCATGCCAGTTTTCCTCCTCAGCTCCTTCCTAGATCAGAGAGCACA GAAAATCAAAGTTATGCTAAACATTCTGCCAATATGAATTTCTCTAATCATAACAATGTTCGAGCTAAT ACTGCATACCATTTACATCAGAGACTTGGCCCAGCAAGACATGGGGAAATGTGGGCCATCTCACCAAAC GACCGACTTATTCCTGCAGTAACTCGAAGTACAATCCAGCGACAAAGTAGTGTGTCCTCCACAGCCTCT GTAAATCTTGGTGATCCAGGCTCTACAAGGCGGGCTCAGATTCCTGAAGGAGATTATTTATCATACAGA GAGTTCCACTCAGCGGGAAGAACTCCTCCAATGATGCCAGGATCACAGAGACCCCTTTCTGCACGAACA TACAGCATAGATGGTCCAAATGCATCAAGACCTCAGAGTGCTCGACCCTCTATTAATGAAATACCAGAG AGAACTATGTCAGTTAGTGATTTCAATTATTCACGGACTAGTCCTTCAAAAAGACCAAATGCAAGGGTT GGTTCTGAGCATTCTTTATTAGATCCTCCAGGAAAAAGTAAAGTTCCTCGTGACTGGAGAGAACAAGTA CTTCGACATATTGAAGCCAAAAAGTTAGAAAAGATGCCTTTGAGTAATGGACAGATGGGCCAGCCTCTC AGGCCTCAGGCAAATTATAGTCAAATACATCACCCCCCTCAGGCATCTGTGGCAAGGCATCCCTCTAGA GAACAACTAATTGATTACTTGATGCTGAAAGTGGCCCACCAGCCTCCATATACACAGCCCCATTGTTCT CCTAGACAAGGCCATGAACTGGCAAAACAAGAGATTCGAGTGAGGGTTGAAAAGGATCCAGAACTTGGA TTTAGCATATCAGGTGGTGTCGGGGGTAGAGGAAACCCATTCAGACCTGATGATGATGGTATATTTGTA ACAAGGGTACAACCTGAAGGACCAGCATCAAAATTACTGCAGCCAGGTGATAAAATTATTCAGGCTAAT GGCTACAGTTTTATAAATATTGAACATGGACAAGCAGTGTCCTTGCTAAAAACTTTCCAGAATACAGTT GAACTCATCATTGTACGAGAAGTTTCCTCATAA
Restriction Sites	SgfI-MluI
ACCN	NM_001253701
Insert Size	4104 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001253701.1
RefSeq Size	6907 bp
RefSeq ORF	4104 bp
Locus ID	55914
UniProt ID	Q96RT1
Protein Families	Druggable Genome
Protein Pathways	NOD-like receptor signaling pathway
MW	153.5 kDa
Gene Summary	This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Transcript Variant: This variant (9) uses an alternate splice site and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (9) is shorter than isoform 1.

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