DAB2 (NM_001244871) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	DOC-2; DOC2
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332100 representing NM_001244871. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGTCTAACGAAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGCCGCACCAAAAGCACCC TCAAAGAAGGAAAAAAAGAAAGGCCCTGAAAAGACAGATGAATATCTCTTAGCAAGGTTCAAAGGCGAT GGTGTAAAATATAAGGCCAAGCTGATTGGCATTGATGATGTGCCAGATGCAAGAGGGGATAAAATGAGC CAAGACTCTATGATGAAACTAAAGGGAATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGG ATCTGGGTCAACATTTCCCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGGTAATAGAGCATGAA CATCCAGTAAATAAGATTTCTTTCATTGCCCGTGATGTGACAGACAACCGGGCATTTGGTTACGTGTGT GGAGGAGAAGGCCAGCATCAGTTTTTTGCCATAAAAACCGGGCAACAGGCTGAACCATTAGTTGTTGAT CTTAAAGACCTTTTTCAAGTTATCTATAATGTAAAGAAAAAGGAAGAAGAAAAGAAAAAGATAGAGGAA GCCAGCAAAGCAGTTGAGAATGGGAGTGAGGCCCTAATGATTCTAGATGACCAAACTAACAAACTGAAA TCGGAAAGCAAAGATATCCTGTTAGTGGATCTAAACTCTGAAATCGACACCAATCAGAATTCTTTAAGA GAAAATCCATTCTTAACAAACGGCATCACCTCCTGTTCTCTTCCTCGACCAACGCCTCAGGCATCCTTC TTGCCTGAAAATGCCTTTTCTGCCAATCTCAACTTCTTTCCCACCCCTAATCCTGATCCTTTCCGTGAC GATCCTTTCACACAGCCAGACCAATCGACACCTTCTTCGTTTGATTCTCTCAAATCTCCAGATCAGAAG AAAGAGAATTCGAGTAGCTCGTCTACTCCGCTGAGTAATGGGCCCCTGAATGGTGATGTTGACTACTTT GGTCAGCAATTTGACCAGATCTCTAACCGGACTGGCAAACAGGAAGCTCAGGCAGGCCCATGGCCCTTT TCAAGTTCGCAAACCCAGCCAGCAGTGAGAACTCAAAATGGGGTATCTGAAAGAGAACAGAACGGCTTC TCTGTCAAATCCTCCCCGAACCCTTTTGTGGGAAGCCCTCCCAAAGGACTGTCCATACAGAATGGCGTA AAGCAGGACTTGGAAAGCTCTGTCCAGTCCTCACCACATGACTCCATAGCCATTATCCCACCTCCACAA AGTACCAAACCAGGAAGAGGCAGAAGGACTGCTAAGTCTTCAGCCAATGACTTGCTTGCATCAGACATC TTTGCTCCTCCCGTCTCAGAACCTTCAGGCCAGGCGTCACCCACAGGACAACCTACAGCCCTGCAGCCC AACCCTCTGGATCTCTTCAAAACAAGTGCTCCTGCCCCAGTGGGGCCCCTGGTGGGTCTAGGTGGTGTA ACTGTCACACTCCCTCAGGCAGGACCATGGAACACAGCATCTTTGGTCTTCAATCAGTCCCCTTCAATG GCTCCGGGAGCCATGATGGGTGGTCAACCTTCAGGTTTTAGTCAGCCCGTCATTTTTGGTACAAGTCCA GCTGTTTCAGGTTGGAACCAGCCTTCACCCTTTGCAGCCTCAACTCCCCCTCCAGTGCCTGTTGTCTGG GGCCCTTCTGCATCTGTGGCACCCAATGCTTGGTCAACAACAAGCCCTTTGGGGAATCCTTTTCAGAGC AATATTTTTCCAGCTCCTGCTGTGTCCACTCAGCCCCCATCCATGCACTCCTCTCTCCTGGTCACTCCT CCTCAGCCACCTCCCAGAGCTGGCCCTCCCAAGGACATCTCCAGTGATGCCTTCACTGCCTTAGACCCA CTTGGGGATAAAGAGATCAAGGATGTGAAAGAAATGTTTAAGGATTTCCAACTGCGGCAGCCACCTGCT GTGCCCGCGCGGAAGGGAGAGCAGACTTCTTCTGGGACTTTGAGTGCCTTTGCCAGTTATTTCAACAGC AAGGTTGGCATTCCTCAGGAGAATGCAGACCATGATGACTTTGATGCTAATCAACTATTGAACAAGATC AATGAACCACCAAAGCCAGCTCCCAGACAAGTTTCCCTGCCAGTTACCAAATCTACTGACAATGCATTT GAGAACCCTTTCTTTAAAGATTCTTTTGGTTCATCACAAGCCTCTGTGGCTTCTTCTCAACCTGTATCT TCTGAGATGTATAGGGATCCATTTGGAAATCCTTTTGCCTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001244871
Insert Size	2250 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001244871.1
RefSeq Size	4554 bp
RefSeq ORF	2250 bp
Locus ID	1601
UniProt ID	P98082
Protein Families	Druggable Genome
Protein Pathways	Endocytosis
MW	80.2 kDa
Gene Summary	This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.

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