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Antizyme inhibitor 1 (AZIN1) (NM_148174) Human Untagged Clone
CAT＃: SC324495
AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 2
CNY 2,950.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_148174.2
ATCGCGGCCGCAGTTTTTCCTTTTTTCTTCTGCCGTCGCCTTCTCTGCCTCTTCTCATCC
TTTCTCGCTCTGCTGCTCTGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCG CCTTTCTTCTTTTGCCTGCGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCA CACAGCTGGTGTCGGTGCCGCGCTTTTACCCCCAAGTCGTTCCCGCAGCCTATGGCCCAG GCCGCCTTGGGTATTTCTGCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAA AGAGAAGACGCTTTACCCGACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAG TATACAACTACCCAGAGGGCCTAGGAGAAGTGCTGTATAGAGAGCAGTTCGACTTCAACG CTGAGCCACCTTGGGAACCTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATT TTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCCGTCTCTTGTCTTTCCTGG TTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGGATTTATTGATGATGCAAA CTACTCCGTTGGCCTGTTGGATGAAGGAACAAACCTTGGAAATGTTATTGATAACTATGT TTATGAACATACCCTGACAGGGAAAAATGCATTTTTTGTGGGAGATCTTGGAAAGATTGT GAAGAAACACAGTCAATGGCAGAATGTAGTGGCTCAGATAAAGCCATTCTACACAGTGAA GTGCAACTCTGCTCCAGCTGTACTTGAGATTTTGGCAGCTCTTGGAACCGGATTTGCTTG TTCCAGTAAAAATGAAATGGCTTTAGTGCAAGAGTTGGGTGTACCTCCAGAAAACATTAT TTACATAAGTCCTTGCAAGCAAGTGTCTCAGATAAAGTATGCAGCAAAAGTTGGAGTGAA TATCCTGACATGTGACAATGAAATTGAATTGAAGAAAATTGCACGTAATCACCCAAATGC CAAGGTCTTACTACATATTGCAACAGAAGATAATATTGGAGGTGAAGAGGGTAACATGAA GTTTGGCACTACCCTGAAGAACTGTAGGCATCTCTTGGAATGTGCTAAGGAACTTGATGT CCAAATAATTGGGGTTAAATTTCATGTTTCGAGTGCTTGCAAAGAATCTCAAGTATATGT ACATGCTCTATCTGATGCTCGATGTGTGTTTGACATGGCTGGAGAAATTGGCTTTACGAT GAACATGTTAGACATTGGTGGAGGATTCACGGGAACTGAATTTCAATTGGAAGAGGTTAA TCATGTTATCAGCCCTCTGTTGGATATCTACTTTCCTGAAGGATCTGGTGTTAAGATAAT TTCAGAACCCGGAAGCTACTATGTGTCTTCTGCATTTACACTCGCAGTTAATATCATAGC AAAGAAAGTTGTTGAAAATGATAAATTTCCCTCTGGAGTAGAAAAAACCGGAAGTGATGA ACCAGCCTTCATGTATTATATGAATGATGGTGTTTATGGTTCTTTTGCAAGTAAACTGTC TGAGGACTTAAATACCATTCCAGAGGTTCACAAGAAATACAAGGAAGATGAGCCTCTGTT TACAAGCAGCCTTTGGGGTCCATCCTGTGATGAGCTTGATCAAATTGTGGAAAGCTGTCT TCTTCCTGAGCTGAATGTGGGAGATTGGCTTATCTTTGATAACATGGGAGCAGATTCTTT CCATGAACCATCTGCTTTTAATGATTTTCAGAGGCCAGCCATTTATTACATGATGTCATT CAGTGATTGGTATGAGATGCAAGATGCTGGAATTACTTCAGACTCAATGATGAAGAACTT CTTCTTTGTGCCTTCTTGCATTCAGCTGAGCCAAGAAGACAGCTTTTCCGCTGAAGCTTA AACAGGCATTAACGCTTCTTTAGATCTGAAGTTGCAGGTTAAGCTTGTCTGGTCAACATT CCAGTGTGGAAAAATAATTTAAACAATCTTATTCTCTTAATTCTTTTGGCAACAAAAACT ATTAGTAATAGCTATTTGGGACCAGACAAAATCAGCTTTCATCTATAATTCATTGGGGAT AATGGGAGATTTAGATAATGTATCCAGATTTAAACCTACCAGTTTGTCCTACCCCTTAAG CGTTTAAAATAAAATATGCAACAAAATGGATGACTTAGTGGAGATGGAAGCCCATTAATT GGGTTCCCCATTAAATCGTTTACATACAAGAACACAGTTTTTATACTAAGGATTTGTGTT TAAAGTCTTGTAAAGTTCATGTCTTTCACCCAGATATATCAAATGTTAGAAGACCAGTGT GACTTCATTAGATAACGTTTAGTGTATTTAGAATGTGTAAATTTGTGCTTTGAACTGTAG TTTAATAAATGTAAAATTGCATCATAGTATTTGTTGACCTAATGTAACCCTTGTATGATT GCAATAAAATTTTGTGTAGATTTTAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_148174 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_148174.2, NP_680479.1 |
| RefSeq Size | 4202 bp |
| RefSeq ORF | 1347 bp |
| Locus ID | 51582 |
| UniProt ID | O14977 |
| Domains | Orn_Arg_deC_N |
| Protein Families | Druggable Genome |
| Gene Summary | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201198 | AZIN1 (Myc-DDK-tagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 2 |
CNY 3,656.00 |
|
| RC201198L3 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201198L4 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG201198 | AZIN1 (tGFP-tagged) - Human antizyme inhibitor 1 (AZIN1), transcript variant 2 |
CNY 4,370.00 |
|
| SC126609 | AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 2 |
CNY 2,950.00 |
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