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Antizyme inhibitor 1 (AZIN1) (NM_015878) Human Untagged Clone
CAT＃: SC324431
AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1
CNY 5,488.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_015878.4
CGCAGTTTTTCCTTTTTTCTTCTGCCGTCGCCTTCTCTGCCTCTTCTCATCCTTTCTCGC
TCTGCTGCTCTGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTT CTTTTGCCTGCGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTG GTGTCGGTGCCGCGCTTTTACCCCCAAGTCGTTCCCGCAGCCTATGGCCCAGGCCGCCTT GGGTATTTCTGCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGA CGCTTTACCCGACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAAC TACCCAGAGGGCCTAGGAGAAGTGCTGTATAGAGAGCAGTTCGACTTCAACGCTGAGCCA CCTTGGGAACCTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTT CACTTCAGAAATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCC AGAATTATCTTGTGATTATTTGAGAGATGTATCAGTTTCTTCTGAAGTACAATCAACTGT AGAAGCCTTTGTAGCAGTTTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCC GTCTCTTGTCTTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGG ATTTATTGATGATGCAAACTACTCCGTTGGCCTGTTGGATGAAGGAACAAACCTTGGAAA TGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTTTTTGTGGG AGATCTTGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCTCAGATAAA GCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGCTGTACTTGAGATTTTGGCAGCTCT TGGAACCGGATTTGCTTGTTCCAGTAAAAATGAAATGGCTTTAGTGCAAGAGTTGGGTGT ACCTCCAGAAAACATTATTTACATAAGTCCTTGCAAGCAAGTGTCTCAGATAAAGTATGC AGCAAAAGTTGGAGTGAATATCCTGACATGTGACAATGAAATTGAATTGAAGAAAATTGC ACGTAATCACCCAAATGCCAAGGTCTTACTACATATTGCAACAGAAGATAATATTGGAGG TGAAGAGGGTAACATGAAGTTTGGCACTACCCTGAAGAACTGTAGGCATCTCTTGGAATG TGCTAAGGAACTTGATGTCCAAATAATTGGGGTTAAATTTCATGTTTCGAGTGCTTGCAA AGAATCTCAAGTATATGTACATGCTCTATCTGATGCTCGATGTGTGTTTGACATGGCTGG AGAAATTGGCTTTACGATGAACATGTTAGACATTGGTGGAGGATTCACGGGAACTGAATT TCAATTGGAAGAGGTTAATCATGTTATCAGCCCTCTGTTGGATATCTACTTTCCTGAAGG ATCTGGTGTTAAGATAATTTCAGAACCCGGAAGCTACTATGTGTCTTCTGCATTTACACT CGCAGTTAATATCATAGCAAAGAAAGTTGTTGAAAATGATAAATTTCCCTCTGGAGTAGA AAAAACCGGAAGTGATGAACCAGCCTTCATGTATTATATGAATGATGGTGTTTATGGTTC TTTTGCAAGTAAACTGTCTGAGGACTTAAATACCATTCCAGAGGTTCACAAGAAATACAA GGAAGATGAGCCTCTGTTTACAAGCAGCCTTTGGGGTCCATCCTGTGATGAGCTTGATCA AATTGTGGAAAGCTGTCTTCTTCCTGAGCTGAATGTGGGAGATTGGCTTATCTTTGATAA CATGGGAGCAGATTCTTTCCATGAACCATCTGCTTTTAATGATTTTCAGAGGCCAGCCAT TTATTACATGATGTCATTCAGTGATTGGTATGAGATGCAAGATGCTGGAATTACTTCAGA CTCAATGATGAAGAACTTCTTCTTTGTGCCTTCTTGCATTCAGCTGAGCCAAGAAGACAG CTTTTCCGCTGAAGCTTAAACAGGCATTAACGCTTCTTTAGATCTGAAGTTGCAGGTTAA GCTTGTCTGGTCAACATTCCAGTGTGGAAAAATAATTTAAACAATCTTATTCTCTTAATT CTTTTGGCAACAAAAACTATTAGTAATAGCTATTTGGGACCAGACAAAATCAGCTTTCAT CTATAATTCATTGGGGATAATGGGAGATTTAGATAATGTATCCAGATTTAAACCTACCAG TTTGTCCTACCCCTTAAGCGTTTAAAATAAAATATGCAACAAAATGGATGACTTAGTGGA GATGGAAGCCCATTAATTGGGTTCCCCATTAAATCGTTTACATACAAGAACACAGTTTTT ATACTAAGGATTTGTGTTTAAAGTCTTGTAAAGTTCATGTCTTTCACCCAGATATATCAA ATGTTAGAAGACCAGTGTGACTTCATTAGATAACGTTTAGTGTATTTAGAATGTGTAAAT TTGTGCTTTGAACTGTAGTTTAATAAATGTAAAATTGCATCATAGTATTTGTTGACCTAA TGTAACCCTTGTATGATTGCAATAAAATTTTGTGTAGATTTTACTGTTTTTTCAGGCTAA AACTTTGGGAAAGGGGCTAGCTAGCAAAGGTAGTTTTGAAATAGATGTGTATATGGACTG TTTTGAAGGGTTTTTTTCTTTATAGCCCAGTTAAGTTTTGTTTGGCTCGGTGCATTTTTC ATTTATTTAATTAGTAATTTAAGTAAAGTGTTTGGTAAATCATAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_015878 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_015878.4, NP_056962.2 |
| RefSeq Size | 4348 bp |
| RefSeq ORF | 1347 bp |
| Locus ID | 51582 |
| UniProt ID | O14977 |
| Domains | Orn_Arg_deC_N |
| Protein Families | Druggable Genome |
| Gene Summary | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200022 | AZIN1 (Myc-DDK-tagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1 |
CNY 5,320.00 |
|
| RC200022L1 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC200022L2 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC200022L3 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC200022L4 | Lenti ORF clone of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG200022 | AZIN1 (tGFP-tagged) - Human antizyme inhibitor 1 (AZIN1), transcript variant 1 |
CNY 7,088.00 |
|
| SC125518 | AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1 |
CNY 5,488.00 |
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