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TAB1 (NM_006116) Human Untagged Clone
CAT＃: SC322672
TAB1 (untagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha
CNY 5,640.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | 3'-Tab1; MAP3K7IP1 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for SC322672
CTCTAGCCGCCCCACTCGCTGCTCTGCGGGGAGGCGGGCGCTCCCGCAGGGGTTCCTCCA
AGATGGCGGCGCAGAGGAGGAGCTTGCTGCAGAGTGAGCAGCAGCCAAGCTGGACAGATG ACCTGCCTCTCTGCCACCTCTCTGGGGTTGGCTCAGCCTCCAACCGCAGCTACTCTGCTG ATGGCAAGGGCACTGAGAGCCACCCGCCAGAGGACAGCTGGCTCAAGTTCAGGAGTGAGA ACAACTGCTTCCTGTATGGGGTCTTCAACGGCTATGATGGCAACCGAGTGACCAACTTCG TGGCCCAGCGGCTGTCCGCAGAGCTCCTGCTGGGCCAGCTGAATGCCGAGCACGCCGAGG CCGATGTGCGGCGTGTGCTGCTGCAGGCCTTCGATGTGGTGGAGAGGAGCTTCCTGGAGT CCATTGACGACGCCTTGGCTGAGAAGGCAAGCCTCCAGTCGCAATTGCCAGAGGGAGTCC CTCAGCACCAGCTGCCTCCTCAGTATCAGAAGATCCTTGAGAGACTCAAGACGTTAGAGA GGGAAATTTCGGGAGGGGCCATGGCCGTTGTGGCGGTCCTTCTCAACAACAAGCTCTACG TCGCCAATGTCGGTACAAACCGTGCACTTTTATGCAAATCGACAGTGGATGGGTTGCAGG TGACACAGCTGAACGTGGACCACACCACAGAGAACGAGGATGAGCTCTTCCGTCTTTCGC AGCTGGGCTTGGATGCTGGAAAGATCAAGCAGGTGGGGATCATCTGTGGGCAGGAGAGCA CCCGGCGGATCGGGGATTACAAGGTTAAATATGGCTACACGGACATTGACCTTCTCAGCG CTGCCAAGTCCAAACCAATCATCGCAGAGCCAGAAATCCATGGGGCACAGCCGCTGGATG GGGTGACGGGCTTCTTGGTGCTGATGTCGGAGGGGTTGTACAAGGCCCTAGAGGCAGCCC ATGGGCCTGGGCAGGCCAACCAGGAGATTGCTGCGATGATTGACACTGAGTTTGCCAAGC AGACCTCCCTGGACGCAGTGGCCCAGGCCGTCGTGGACCGGGTGAAGCGCATCCACAGCG ACACCTTCGCCAGTGGTGGGGAGCGTGCCAGGTTCTGCCCCCGGCACGAGGACATGACCC TGCTAGTGAGGAACTTTGGCTACCCGCTGGGCGAAATGAGCCAGCCCACACCGAGCCCAG CCCCAGCTGCAGGAGGACGAGTGTACCCTGTGTCTGTGCCATACTCCAGCGCCCAGAGCA CCAGCAAGACCAGCGTGACCCTCTCCCTTGTCATGCCCTCCCAGGGCCAGATGGTCAACG GGGCTCACAGTGCTTCCACCCTGGACGAAGCCACCCCCACCCTCACCAACCAAAGCCCGA CCTTAACCCTGCAGTCCACCAACACGCACACGCAGAGCAGCAGCTCCAGCTCTGACGGAG GCCTCTTCCGCTCCCGGCCCGCCCACTCGCTCCCGCCTGGCGAGGACGGTCGTGTTGAGC CCTATGTGGACTTTGCTGAGTTTTACCGCCTCTGGAGCGTGGACCATGGCGAGCAGAGCG TGGTGACAGCACCGTAGGGCAGCCGGAGAATGCAGCCCAAGCAGGGCCTGGCATGGGGCA GGACAGGGTCCAGCCTTTTCCTAACATCTGCCTGTGCCACAACGGCCAGCAGGTGCCCCA TCCTCTGCCCACAGCAGACTCTGTCCCATGGCTCTCCGGGCAGTAGAGTGTGTGAGTGCA GACTGGACCTGTGGTTCATACCTTGTCACCACCCGGGAAGCTGAAGGCCACTTCCTCCCA GATGGCCTCAGCCAGGACCATCGCCCTTTCTCAGAGCAGAGGGCCAGGTATAGAAACCGC AGTGGGCCTGCAAGCCGCCCGAGCCTCCCCAGCAGCCTCCTACAGAGCAGGAAGAGGCGC CCTGTGAACCCTGAGTGTTGCAGGCCCAGCAGACCCTGCTGTCCCAAGCCCACCCCTCCT CCCACCATCACCTCCCTCACCTCGGGACAGTAGCCCTCCACTTCTCCAGCCTCTCAGCCC TGTGCTCCTGCATCCAGAGTGGAACCCAGGCTGGTGTCCGCATCTGTCCCTGGGCCCCAC CCCTGGACCTGCCTTGGTTGTGTCATCTGTTGTAAACGTTCAGGAGGACCAGGGCAGCAT CTGGGGCCTGGGATGGCCACAGAAGGGGCAGGCCAGGTGGAAAGGAGCCAGGGGGAAGTG GTCTAAGAGACCTGGAACTGCCAGAGGATGGCGGCCTGGGCTTCCCCAGAGCCAGGCGTG CGGGAGAGGTGAGGACTGGCCCCGGTGGGCTGAGGCAGGGGCCGCTGTCGTCAGGCCTGA GCCAGGGTGAGCTGGTGCCTGCCTTGCATTTTCCTTCTGGTGCTGTGAAGACCATAGGCT GGCAGGCAGCTGAGATGAACTGTCTTTACCACTGATGAGGGGCCTCTGCCGGCTGAGGGT AGCAAGCAGGGGTTGTGAGTCAGGCTGGGGGACTTGTTTGAAAGAAAGAGGAGTGGAAAA TGGTTCCAGGAGGGAAGAGGTTCTTTGAGACACAGTACCCTGGGAGGCATAGGAGAAGGG TCGGGCCAGCCCAGCCCAGGGCCTGAGTTAGACTATTTCCCACATGTTCTCTGCCTTCAG TGGGGAGGGGGTGCCACCAGGGCTGTCGGCCAGGATTGCCACTCCTGTTTCAGAGGAAGC AGGCCGAGAGACTTGCACCTTGGCCAAGCCACACAATCAGTGGGGCAGCCAGAGCTCAGA CCTGAGCCATTTTGTCAGTATCCAGGACCCCCCGGATTCTCCACGCCCTCCCCATCTCCC AGTCTCCCTGCCCCCCATGCCCCAGACCGGCCCACCAGGGACTAGCCGCTGTCGCACAGC CTCTGGGGTGCTTGGTCTCTGCGAAGTCAAAGGCCTGACAGCTCTGTGGCCTGGGAATCC ATTTTCCTGCGGCAGAGCAGGGCCTGGTGTGGAACCAGGGAGCTGTGGGAAGCCACAGCA GAAATGGAAGAAAAACAGGTCTCAGCCCAGGGTCCTCGCTCACTCCCTCACTCCCCACTT TGAAGCCATCTCTGTTCTGCAGGTGAGAGGATTTAAAGTCAGTCACAAAGGCTTGGGAAC AAAAGGAATTCTCTTCCAAGAATGCCTCTGTGGTGCTGTTTGGTCTCTAGAAACAGGGTC ACTTTTTTAATGTAGTAAAGAAGTAATAAATGGTGGCATTACACATTGTGATATTAAAAA AAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_006116 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006116.2, NP_006107.1 |
| RefSeq Size | 3240 bp |
| RefSeq ORF | 1515 bp |
| Locus ID | 10454 |
| UniProt ID | Q15750 |
| Domains | PP2C |
| Protein Families | Druggable Genome |
| Protein Pathways | MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway |
| Gene Summary | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (alpha) encodes the longer isoform (alpha). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208522 | TAB1 (Myc-DDK-tagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha |
CNY 5,632.00 |
|
| RC208522L1 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha, Myc-DDK-tagged |
CNY 8,032.00 |
|
| RC208522L2 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha, mGFP tagged |
CNY 5,890.00 |
|
| RC208522L3 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha, Myc-DDK-tagged |
CNY 8,032.00 |
|
| RC208522L4 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha, mGFP tagged |
CNY 8,032.00 |
|
| RG208522 | TAB1 (tGFP-tagged) - Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha |
CNY 7,232.00 |
|
| SC116337 | TAB1 (untagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha |
CNY 5,640.00 |
