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DAB2 (NM_001343) Human Untagged Clone
CAT＃: SC321375
DAB2 (untagged)-Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2)
CNY 2,950.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DOC-2; DOC2 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001343.1
CGCTTCACGGAGGCAATAGCTAGCCGGTGTCTGTGGGAGGTTATGTTTATTTGAGAGTTC
TCCATCGGGATCGCCTGGTGTCACCAAGTGTCCACTGGTACTGAGGTTTGCTGCCTGCCT TCTTGCCATGTCTAACGAAGTAGAAACAAGTGCAACCAATGGTCAGCCCGACCAACAGGC CGCACCAAAAGCACCCTCAAAGAAGGAAAAAAAGAAAGGCCCTGAAAAGACAGATGAATA TCTCTTAGCAAGGTTCAAAGGCGATGGTGTAAAATATAAGGCCAAGCTGATTGGCATTGA TGATGTGCCAGATGCAAGAGGGGATAAAATGAGCCAAGACTCTATGATGAAACTAAAGGG AATGGCGGCAGCTGGTCGGTCTCAGGGACAACACAAACAAAGGATCTGGGTCAACATTTC CCTTTCTGGGATAAAAATAATTGATGAGAAAACTGGGGTAATAGAGCATGAACATCCAGT AAATAAGATTTCTTTCATTGCCCGTGATGTGACAGACAACCGGGCATTTGGTTACGTGTG TGGAGGAGAAGGCCAGCATCAGTTTTTTGCCATAAAAACCGGGCAACAGGCTGAACCATT AGTTGTTGATCTTAAAGACCTTTTTCAAGTTATCTATAATGTAAAGAAAAAGGAAGAAGA AAAGAAAAAGATAGAGGAAGCCAGCAAAGCAGTTGAGAATGGGAGTGAGGCCCTAATGAT TCTAGATGACCAAACTAACAAACTGAAATCGGGTGTTGACCAGATGGATTTGTTTGGGGA CATGTCTACACCTCCTGACCTAAATAGTCCAACAGAAAGCAAAGATATCCTGTTAGTGGA TCTAAACTCTGAAATCGACACCAATCAGAATTCTTTAAGAGAAAATCCATTCTTAACAAA CGGCATCACCTCCTGTTCTCTTCCTCGACCAACGCCTCAGGCATCCTTCTTGCCTGAAAA TGCCTTTTCTGCCAATCTCAACTTCTTTCCCACCCCTAATCCTGATCCTTTCCGTGACGA TCCTTTCACACAGCCAGACCAATCGACACCTTCTTCGTTTGATTCTCTCAAATCTCCAGA TCAGAAGAAAGAGAATTCGAGTAGCTCGTCTACTCCGCTGAGTAATGGGCCCCTGAATGG TGATGTTGACTACTTTGGTCAGCAATTTGACCAGATCTCTAACCGGACTGGCAAACAGGA AGCTCAGGCAGGCCCATGGCCCTTTTCAAGTTCGCAAACCCAGCCAGCAGTGAGAACTCA AAATGGGGTATCTGAAAGAGAACAGAACGGCTTCTCTGTCAAATCCTCCCCGAACCCTTT TGTGGGAAGCCCTCCCAAAGGACTGTCCATACAGAATGGCGTAAAGCAGGACTTGGAAAG CTCTGTCCAGTCCTCACCACATGACTCCATAGCCATTATCCCACCTCCACAAAGTACCAA ACCAGGAAGAGGCAGAAGGACTGCTAAGTCTTCAGCCAATGACTTGCTTGCATCAGACAT CTTTGCTCCTCCCGTCTCAGAACCTTCAGGCCAGGCGTCACCCACAGGACAACCTACAGC CCTGCAGCCCAACCCTCTGGATCTCTTCAAAACAAGTGCTCCTGCCCCAGTGGGGCCCCT GGTGGGTCTAGGTGGTGTAACTGTCACACTCCCTCAGGCAGGACCATGGAACACAGCATC TTTGGTCTTCAATCAGTCCCCTTCAATGGCTCCGGGAGCCATGATGGGTGGTCAACCTTC AGGTTTTAGTCAGCCCGTCATTTTTGGTACAAGTCCAGCTGTTTCAGGTTGGAACCAGCC TTCACCCTTTGCAGCCTCAACTCCCCCTCCAGTGCCTGTTGTCTGGGGCCCTTCTGCATC TGTGGCACCCAATGCTTGGTCAACAACAAGCCCTTTGGGGAATCCTTTTCAGAGCAATAT TTTTCCAGCTCCTGCTGTGTCCACTCAGCCCCCATCCATGCACTCCTCTCTCCTGGTCAC TCCTCCTCAGCCACCTCCCAGAGCTGGCCCTCCCAAGGACATCTCCAGTGATGCCTTCAC TGCCTTAGACCCACTTGGGGATAAAGAGATCAAGGATGTGAAAGAAATGTTTAAGGATTT CCAACTGCGGCAGCCACCTGCTGTGCCCGCGCGGAAGGGAGAGCAGACTTCTTCTGGGAC TTTGAGTGCCTTTGCCAGTTATTTCAACAGCAAGGTTGGCATTCCTCAGGAGAATGCAGA CCATGATGACTTTGATGCTAATCAACTATTGAACAAGATCAATGAACCACCAAAGCCAGC TCCCAGACAAGTTTCCCTGCCAGTTACCAAATCTACTGACAATGCATTTGAGAACCCTTT CTTTAAAGATTCTTTTGGTTCATCACAAGCCTCTGTGGCTTCTTCTCAACCTGTATCTTC TGAGATGTATAGGGATCCATTTGGAAATCCTTTTGCCTAAATTCTGAACTTGGTCTGCAG ACCATCCAGAGGAATAAAAAGGTTGGCCTTAGTAGTCAAAAACAAAGCTGATAGCCAGAC ACGTTCTGATTTCTGCCCTTGTTCCAGCTTTGACGTATTATCTGTTGCCTTATTTCTCAT TGCCTCTTCTACTTGTAAAATGCTTTTCACTTTCTGTCTAGGTTAAAGCTAAACTGAATC TATGGCTTTAAATAAATTAAGATCCTAAACTCTCTAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001343 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001343.1, NP_001334.1 |
| RefSeq Size | 3268 bp |
| RefSeq ORF | 2313 bp |
| Locus ID | 1601 |
| UniProt ID | P98082 |
| Domains | PID |
| Protein Families | Druggable Genome |
| Protein Pathways | Endocytosis |
| Gene Summary | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The histone demethylase Kdm3a is essential to progression through differentiation
,Marielle Herzog, Eléonore Josseaux, Sarah Dedeurwaerder, Emilie Calonne, Michael Volkmar, and François Fuks,
Nucleic Acids Res., Aug 2012; 40: 7219 - 7232.
[Dab2]
|
|
Disabled-2 Protein Facilitates Assembly Polypeptide-2-independent Recruitment of Cystic Fibrosis Transmembrane Conductance Regulator to Endocytic Vesicles in Polarized Human Airway Epithelial Cells *
,null,
The Journal of Biological Chemistry
,PubMed ID 22399289
[DAB2]
|
|
Disabled-2 Protein Facilitates Assembly Polypeptide-2-independent Recruitment of Cystic Fibrosis Transmembrane Conductance Regulator to Endocytic Vesicles in Polarized Human Airway Epithelial Cells
,Kristine M. Cihil, Philipp Ellinger, Abigail Fellows, Donna Beer Stolz, Dean R. Madden, and Agnieszka Swiatecka-Urban,
J. Biol. Chem., Apr 2012; 287: 15087 - 15099.
[DAB2]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200481 | DAB2 (Myc-DDK-tagged)-Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2) |
CNY 5,320.00 |
|
| RC200481L1 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), Myc-DDK-tagged |
CNY 8,040.00 |
|
| RC200481L2 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), mGFP tagged |
CNY 8,460.00 |
|
| RC200481L3 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), Myc-DDK-tagged |
CNY 8,460.00 |
|
| RC200481L4 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), mGFP tagged |
CNY 8,040.00 |
|
| RG200481 | DAB2 (tGFP-tagged) - Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2) |
CNY 7,220.00 |
