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Constitutive androstane receptor (NR1I3) (NM_001077482) Human Untagged Clone
CAT＃: SC315540
NR1I3 (untagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1
CNY 3,656.00
CNY 5,800.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CAR; CAR1; MB67 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001077482 edited
ATGGCCAGTAGGGAAGATGAGCTGAGGAACTGTGTGGTATGTGGGGACCAAGCCACAGGC TACCACTTTAATGCGCTGACTTGTGAGGGCTGCAAGGGTTTCTTCAGGAGAACAGTCAGC AAAAGCATTGGTCCCACCTGCCCCTTTGCTGGAAGCTGTGAAGTCAGCAAGACTCAGAGG CGCCACTGCCCAGCCTGCAGGTTGCAGAAGTGCTTAGATGCTGGCATGAGGAAAGACATG ATACTGTCGGCAGAAGCCCTGGCATTGCGGCGAGCAAAGCAGGCCCAGCGGCGGGCACAG CAAACACCTGTGCAACTGAGTAAGGAGCAAGAAGAGCTGATCCGGACACTCCTGGGGGCC CACACCCGCCACATGGGCACCATGTTTGAACAGTTTGTGCAGTTTAGGCCTCCAGCTCAT CTGTTCATCCATCACCAGCCCTTGCCCACCCTGGCCCCTGTGCTGCCTCTGGTCACACAC TTCGCAGACATCAACACTTTCATGGTACTGCAAGTCATCAAGTTTACTAAGGACCTGCCC GTCTTCCGTTCCCTGCCCATTGAAGACCAGATCTCCCTTCTCAAGGGAGCAGCTGTGGAA ATCTGTCACATCGTACTCAATACCACTTTCTGTCTCCAAACACAAAACTTCCTCTGCGGG CCTCTTCGCTACACAATTGAAGATGGAGCCCGTGTATCTCCCACAGTGGGGTTCCAGGTA GAGTTTTTGGAGTTGCTCTTTCACTTCCATGGAACACTACGAAAACTGCAGCTCCAAGAG CCTGAGTATGTGCTCTTGGCTGCCATGGCCCTCTTCTCTCCTGCTCCCTATCTTACAGAC CGACCTGGAGTTACCCAGAGAGATGAGATTGATCAGCTGCAAGAGGAGATGGCACTGACT CTGCAAAGCTACATCAAGGGCCAGCAGCGAAGGCCCCGGGATCGGTTTCTGTATGCGAAG TTGCTAGGCCTGCTGGCTGAGCTCCGGAGCATTAATGAGGCCTACGGGTACCAAATCCAG CACATCCAGGGCCTGTCTGCCATGATGCCGCTGCTCCAGGAGATCTGCAGCTGA >OriGene 5' read for NM_001077482 unedited
GTACGATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCTCATGGCCAGTAGGGAAGA TGAGCTGAGGAACTGTGTGGTATGTGGGGACCAAGCCACAGGCTACCACTTTAATGCGCT GACTTGTGAGGGCTGCAAGGGTTTCTTCAGGAGAACAGTCAGCAAAAGCATTGGTCCCAC CTGCCCCTTTGCTGGAAGCTGTGAAGTCAGCAAGACTCAGAGGCGCCACTGCCCAGCCTG CAGGTTGCAGAAGTGCTTAGATGCTGGCATGAGGAAAGACATGATACTGTCGGCAGAAGC CCTGGCATTGCGGCGAGCAAAGCAGGCCCAGCGGCGGGCACAGCAAACACCTGTGCAACT GAGTAAGGAGCAAGAAGAGCTGATCCGGACACTCCTGGGGGCCCACACCCGCCACATGGG CACCATGTTTGAACAGTTTGTGCAGTTTAGGCCTCCAGCTCATCTGTTCATCCATCACCA GCCCTTGCCCACCCTGGCCCCTGTGCTGCCTCTGGTCACACACTTCGCAGACATCAACAC TTTCATGGTACTGCAAGTCATCAAGTTTACTAAGGACCTGCCCGTCTTCCGTTCCCTGCC CATTGAAGACCAGATCTCCCTTCTCAAGGGAGCAGCTGTGGAAATCTGTCACATCGTACT CAATACCACTTTCTGTCTCCAAACACAAAACTTCCTCTGCGGGCCTCTTCGCTACACAAT TGAAGATGGAGCCCGTGTATCTCCCACAGTGGGGTTCCAGGTAGAGTTTTTGGGAGTTGC TCTTTCACTTTCCATGGAACACTACGAAAACTGCAGCTCCAAGAGCCTGAGTATGTGCTC TTGGCTGCCATGGCCCTCTTCTCTCCTGCTCCCTATCTTACAGACCGACCTGGAGTTACC CAGAGAGATGGAGATTGATCAGCTGCA >OriGene 3' read for NM_001077482 unedited
TGGACGCTGCACTTCAGGGCCGGAGAGGCACCTGGGGAGGGGTCACAGGGATGCCACCCG GGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATCAGCTGCAGATCTCCT GGAGCAGCGGCATCATGGCAGACAGGCCCTGGATGTGCTGGATTTGGTACCCGTAGGCCT CATTAATGCTCCGGAGCTCAGCCAGCAGGCCTAGCAACTTCGCATACAGAAACCGATCCC GGGGCCTTCGCTGCTGGCCCTTGATGTAGCTTTGCAGAGTCAGTGCCATCTCCTCTTGCA GCTGATCAATCTCATCTCTCTGGGTAACTCCAGGTCGGTCTGTAAGATAGGGAGCAGGAG AGAAGAGGGCCATGGCAGCCAAGAGCACATACTCAGGCTCTTGGAGCTGCAGTTTTCGTA GTGTTCCATGGAAGTGAAAGAGCAACTCCAAAAACTCTACCTGGAACCCCACTGTGGGAG ATACACGGGCTCCATCTTCAATTGTGTAGCGAAGAGGCCCGCAGAGGAAGTTTTGTGTTT GGAGACAGAAAGTGGTATTGAGTACGATGTGACAGATTTCCACAGCTGCTCCCTTGAGAA GGGAGATCTGGTCTTCAATGGGCAGGGAACGGAAGACGGGCAGGTCCTTAGTAAACTTGA TGACTTGCAGTACCATGAAAGTGTTGATGTCTGCGAAGTGTGTGACCAGAGGCAGCACAG GGGCCAGGGTGGGCAAAGGGCTGGTGATGGATGAACAGATGAGCTGGAGCCTAAACTGCA CAAACTGTTCAAACATGGTGCCCATGTGGCGGGTGTGGGCCCCCAGGAGTGTCCGGATCA GCTCTTCTTGCTCCTTACTCAGTTGCACAGGTGTTTGCTGTGCCCGCCGCTGGGCCCTGC TTTGCTCGC |
| Restriction Sites | Please inquire |
| ACCN | NM_001077482 |
| Insert Size | 1100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001077482.1, NP_001070950.1 |
| RefSeq Size | 1408 bp |
| RefSeq ORF | 1074 bp |
| Locus ID | 9970 |
| UniProt ID | Q14994 |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
| Gene Summary | This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020] Transcript Variant: This variant (1), also known as SV-25 or CAR2, represents the longest transcript and encodes the longest isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
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THE ROLE OF PESTICIDES IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
,Al-Eryani, L;,
Thesis
[NR1I3]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213905 | NR1I3 (Myc-DDK-tagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1 |
CNY 3,990.00 |
|
| RC213905L1 | Lenti ORF clone of Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC213905L2 | Lenti ORF clone of Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RC213905L3 | Lenti ORF clone of Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC213905L4 | Lenti ORF clone of Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG213905 | NR1I3 (tGFP-tagged) - Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1 |
CNY 4,370.00 |
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