ITPR3 (NM_002224) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	IP3R; IP3R3
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC303153 representing NM_002224. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGAGTGAAATGTCCAGCTTTCTTCACATCGGGGACATCGTCTCCCTGTACGCCGAGGGCTCCGTCAAT GGCTTCATCAGCACTTTGGGGCTGGTGGATGACCGCTGTGTGGTGGAGCCCGCGGCCGGGGACCTGGAC AACCCCCCTAAGAAGTTCCGTGACTGCCTCTTCAAGGTGTGCCCCATGAACCGCTACTCGGCCCAGAAG CAGTACTGGAAGGCCAAGCAGACTAAGCAGGACAAGGAGAAGATCGCTGATGTGGTGTTGCTGCAGAAG CTGCAGCATGCGGCGCAGATGGAGCAGAAGCAAAATGACACGGAGAACAAGAAGGTGCATGGGGATGTC GTGAAGTATGGCAGTGTGATCCAGCTCCTGCACATGAAGAGCAACAAGTACCTGACAGTGAACAAGCGG CTTCCGGCCTTGCTGGAGAAGAACGCCATGCGGGTGACTCTGGATGCCACAGGCAACGAGGGTTCCTGG CTCTTCATCCAGCCCTTCTGGAAGCTGCGGAGCAACGGGGACAACGTGGTCGTGGGGGACAAGGTGATC CTGAATCCTGTCAATGCCGGGCAGCCTCTGCATGCCAGCAATTACGAGCTCAGCGACAACGCCGGCTGC AAGGAGGTCAATTCTGTGAACTGCAACACCAGCTGGAAGATCAACCTGTTTATGCAGTTTCGGGACCAC CTGGAGGAGGTGTTGAAAGGGGGAGACGTGGTGCGGCTGTTCCATGCGGAGCAGGAGAAGTTCCTGACG TGTGACGAGTACAAGGGCAAGCTGCAGGTGTTCCTGCGAACTACACTGCGCCAGTCTGCCACCTCGGCC ACCAGCTCCAATGCTCTCTGGGAGGTGGAGGTGGTCCACCACGACCCCTGCCGTGGAGGAGCTGGGCAC TGGAATGGCTTGTACCGCTTCAAGCACCTGGCTACAGGCAACTACCTGGCTGCTGAGGAGAACCCCAGT TACAAAGGTGATGCCTCAGATCCCAAGGCAGCAGGAATGGGGGCACAGGGCCGCACAGGCCGCAGGAAT GCTGGGGAGAAGATCAAGTACTGCCTGGTGGCTGTGCCTCATGGCAATGACATCGCCTCTCTCTTTGAG CTGGACCCCACCACCTTGCAGAAAACCGACTCTTTCGTGCCCCGGAACTCGTACGTCCGGCTGCGGCAC CTCTGCACCAACACGTGGATTCAGAGCACCAATGTGCCCATTGACATCGAGGAGGAGCGGCCCATCCGG CTCATGCTGGGCACCTGCCCCACCAAGGAGGACAAGGAGGCCTTTGCCATCGTGTCAGTGCCCGTGTCT GAGATCCGAGACCTGGACTTTGCCAATGACGCCAGCTCCATGCTGGCCAGTGCCGTGGAGAAACTCAAC GAGGGCTTCATCAGCCAGAATGACCGCAGGTTTGTCATCCAGCTGCTGGAAGACCTGGTGTTCTTTGTC AGCGATGTCCCCAACAATGGGCAGAATGTCCTGGACATCATGGTCACTAAGCCCAACCGGGAACGGCAG AAGCTGATGAGGGAGCAGAACATCCTCAAACAGGTCTTTGGCATTCTGAAGGCCCCGTTCCGTGAGAAG GGGGGTGAAGGTCCCCTGGTGCGGCTGGAGGAGCTGTCAGACCAGAAGAACGCCCCCTACCAGCACATG TTCCGCCTGTGCTACCGCGTGTTGCGGCATTCCCAGGAGGACTACCGCAAGAACCAGGAGCACATTGCC AAGCAGTTTGGGATGATGCAGTCCCAGATTGGCTACGACATCCTGGCCGAGGACACCATCACTGCCCTG CTGCACAACAACCGCAAGCTCCTGGAAAAGCACATCACCAAGACCGAGGTGGAGACCTTCGTCAGCCTT GTGCGCAAGAACCGGGAGCCCAGGTTCCTGGACTACCTCTCTGACCTGTGTGTGTCCAACCACATCGCC ATCCCCGTCACCCAAGAGCTCATCTGCAAGTGTGTGCTGGACCCCAAGAACAGTGACATTCTCATCCGG ACCGAGCTTCGGCCCGTGAAGGAGATGGCCCAATCCCACGAGTACCTGAGCATCGAGTACTCAGAAGAG GAAGTGTGGCTCACGTGGACTGACAAGAATAACGAGCATCATGAGAAGAGTGTGAGGCAGCTGGCCCAG GAGGCGCGGGCCGGCAACGCCCACGACGAGAATGTGCTCAGCTACTACAGGTACCAGCTGAAGCTCTTT GCCCGCATGTGCTTGGACCGCCAGTACTTGGCCATCGACGAGATCTCCCAGCAGCTGGGCGTGGACCTG ATTTTCCTGTGCATGGCAGACGAGATGCTGCCCTTTGACCTGCGCGCCTCCTTCTGCCACCTGATGCTG CACGTGCACGTGGACCGTGACCCCCAGGAGCTGGTCACGCCGGTCAAGTTTGCCCGTCTCTGGACTGAG ATCCCCACAGCCATCACCATCAAGGACTATGATTCCAACCTCAACGCGTCCCGAGATGACAAGAAGAAC AAGTTTGCCAACACCATGGAGTTCGTGGAGGACTACCTCAACAATGTAGTCAGCGAGGCCGTGCCCTTT GCCAACGAGGAGAAGAACAAGCTCACTTTTGAGGTGGTCAGCCTGGCGCACAATCTCATCTACTTCGGC TTCTACAGCTTCAGCGAGCTGCTGCGGCTCACTCGCACACTGCTGGGCATCATCGACTGTGTGCAGGGG CCCCCGGCCATGCTGCAGGCCTATGAGGACCCCGGTGGCAAGAATGTGCGGCGGTCCATCCAGGGCGTG GGGCACATGATGTCCACCATGGTGCTGAGCCGCAAGCAGTCCGTCTTCAGTGCCCCCAGCCTGTCTGCT GGGGCCAGTGCTGCTGAGCCGCTGGACAGAAGCAAGTTTGAGGAGAATGAGGACATTGTGGTGATGGAG ACCAAGCTGAAGATCCTGGAAATCCTTCAGTTCATCCTCAATGTCCGCCTGGATTACCGCATATCCTAC CTGCTGTCTGTCTTCAAGAAGGAGTTTGTGGAGGTGTTTCCCATGCAGGACAGTGGGGCTGATGGCACA GCCCCTGCCTTCGACTCTACCACTGCCAACATGAACCTGGATCGCATCGGGGAGCAGGCGGAGGCCATG TTTGGAGTGGGGAAGACAAGCAGCATGCTGGAGGTGGATGACGAGGGCGGCCGCATGTTCCTGCGCGTG CTCATCCACCTCACCATGCACGACTATGCGCCGCTGGTCTCGGGTGCCCTGCAGCTGCTCTTCAAGCAC TTCAGCCAGCGCCAGGAGGCCATGCACACCTTCAAGCAGGTTCAGCTGCTGATCTCAGCGCAGGACGTG GAGAACTACAAGGTGATCAAGTCGGAGCTGGACCGGCTGCGGACCATGGTGGAGAAGTCAGAGCTGTGG GTGGACAAGAAGGGCAGTGGCAAGGGTGAGGAGGTGGAGGCAGGCGCCGCCAAGGACAAGAAAGAGCGT CCCACGGACGAGGAGGGCTTTCTGCACCCACCAGGGGAGAAAAGCAGTGAGAACTACCAGATCGTCAAG GGCATCCTGGAAAGGCTGAACAAGATGTGCGGGGTTGGGGAGCAAATGAGGAAGAAGCAGCAACGGCTG CTGAAGAACATGGATGCCCACAAGGTCATGCTGGACCTGCTGCAGATCCCCTATGACAAGGGTGATGCC AAGATGATGGAGATCCTGCGCTACACGCACCAGTTCCTGCAGAAGTTCTGTGCAGGGAACCCCGGCAAC CAGGCCCTGCTGCACAAACACCTGCACCTCTTCCTCACGCCAGGGCTCCTGGAGGCAGAGACCATGCAG CACATCTTCCTGAACAACTATCAGCTCTGCTCCGAGATCAGCGAGCCTGTGTTGCAGCACTTCGTGCAC CTGCTGGCCACGCACGGGCGCCATGTGCAGTACCTGGACTTCCTGCACACCGTCATTAAGGCCGAGGGC AAGTACGTCAAGAAGTGCCAGGACATGATCATGACTGAGCTGACCAATGCAGGTGACGATGTGGTCGTG TTCTACAATGATAAGGCATCGCTGGCCCACCTGCTGGACATGATGAAGGCCGCCCGCGACGGCGTGGAG GACCACAGCCCCCTCATGTACCACATTTCCCTGGTGGACCTGCTGGCCGCCTGTGCCGAGGGCAAAAAC GTCTACACTGAGATCAAGTGCACCTCCCTGCTGCCGCTGGAGGACGTGGTGTCTGTGGTGACGCATGAG GACTGCATCACTGAGGTGAAAATGGCCTATGTGAACTTCGTGAACCACTGCTACGTGGACACGGAGGTG GAGATGAAGGAGATCTACACCAGCAACCACATCTGGACGCTCTTTGAGAACTTCACCCTGGACATGGCT CGGGTCTGCAGCAAGCGTGAGAAGCGCGTGGCTGACCCCACCTTGGAGAAGTACGTGCTGAGCGTTGTG CTGGACACCATCAACGCCTTCTTCAGCTCCCCATTCTCTGAGAACAGCACTTCCCTGCAGACACACCAG ACGATTGTGGTGCAGCTGCTGCAGTCTACCACACGCCTCCTCGAGTGTCCGTGGCTACAGCAGCAGCAC AAGGGCTCCGTGGAGGCCTGCATCCGGACCCTCGCCATGGTGGCCAAGGGCCGGGCCATCTTGCTGCCC ATGGACCTGGATGCCCACATCAGCTCGATGCTCAGCAGTGGAGCCAGCTGTGCAGCTGCCGCCCAGCGG AACGCCTCCAGCTACAAGGCAACCACGCGGGCCTTCCCCCGCGTCACCCCCACCGCCAACCAGTGGGAC TACAAGAACATCATTGAGAAGCTGCAGGACATCATCACAGCCCTGGAGGAGCGGCTGAAGCCCCTGGTA CAGGCTGAGCTGTCCGTGCTGGTGGATGTCCTGCACTGGCCTGAGCTGCTCTTCCTGGAGGGCAGTGAG GCCTACCAGCGCTGCGAGAGTGGGGGCTTCCTGTCCAAGCTGATCCAGCACACCAAGGACCTCATGGAG TCGGAGGAGAAGCTGTGCATCAAGGTGCTGCGGACCCTGCAGCAGATGCTGCTCAAGAAGACCAAGTAC GGGGACCGGGGCAACCAGCTGCGCAAGATGCTGCTGCAAAACTACCTCCAGAACCGGAAGTCCACCTCG CGGGGGGACCTTCCCGACCCCATAGGCACTGGCCTGGACCCAGACTGGTCGGCAATCGCAGCCACCCAG TGCCGGCTGGACAAGGAGGGGGCCACCAAGTTGGTATGCGACCTCATCACCAGCACCAAGAACGAGAAG ATCTTCCAGGAGAGCATCGGCCTGGCCATCCACCTGCTGGATGGTGGCAACACAGAGATCCAGAAATCC TTCCACAACCTGATGATGAGTGACAAGAAGTCAGAGCGCTTCTTCAAGGTGCTGCACGACCGCATGAAG CGGGCCCAGCAGGAGACCAAGTCCACGGTGGCAGTCAACATGAATGACCTGGGCAGCCAGCCACATGAG GACCGCGAGCCAGTCGACCCCACCACCAAAGGCCGCGTGGCCTCCTTCTCGATACCTGGCTCCTCATCC CGCTACTCGCTGGGCCCCAGCCTGCGCCGGGGGCACGAGGTGAGCGAACGTGTGCAGAGCAGTGAGATG GGCACATCCGTGCTCATCATGCAGCCCATCCTGCGCTTTCTGCAGCTGCTGTGTGAGAACCACAACCGG GACCTGCAGAACTTCCTGCGCTGTCAGAACAACAAAACCAACTACAACTTGGTATGCGAGACGCTGCAG TTCCTGGACATCATGTGCGGCAGCACCACGGGCGGCCTGGGGCTGCTGGGGCTCTACATCAATGAGGAC AACGTGGGCCTCGTCATCCAGACCTTGGAGACCCTCACTGAGTACTGCCAGGGCCCCTGCCATGAGAAC CAGACTTGCATTGTGACTCACGAGTCCAATGGCATAGACATCATCACCGCACTGATCCTCAATGACATC AGCCCCCTGTGCAAGTACCGCATGGATCTGGTGCTGCAGCTCAAGGACAATGCCTCCAAGCTGCTCCTG GCTCTGATGGAGAGCCGGCATGACAGTGAAAATGCTGAGCGAATCCTCATCAGCCTGCGGCCCCAGGAG CTGGTGGACGTCATCAAGAAGGCCTACCTGCAGGAGGAAGAGCGTGAGAACTCGGAGGTGAGCCCACGT GAAGTGGGCCATAACATCTATATCCTGGCGCTGCAGCTCTCCAGGCACAATAAACAGCTGCAGCACCTG CTGAAGCCGGTGAAGCGCATTCAAGAGGAGGAGGCCGAGGGTATCTCTTCCATGCTCAGCCTCAACAAC AAGCAGCTGTCACAGATGCTCAAGTCCTCAGCGCCAGCACAGGAGGAGGAGGAAGACCCCCTGGCCTAC TATGAGAACCACACGTCCCAGATCGAGATTGTGCGGCAGGACCGCAGCATGGAGCAGATCGTGTTCCCA GTGCCCGGCATCTGCCAGTTCCTGACGGAGGAAACCAAGCACCGGCTCTTCACCACTACTGAGCAGGAC GAGCAGGGCAGCAAAGTGAGCGACTTCTTCGACCAGTCCTCCTTCCTGCACAACGAGATGGAGTGGCAG CGCAAGCTCCGCAGCATGCCGCTGATCTACTGGTTCTCCCGCCGCATGACCCTGTGGGGCAGCATCTCC TTCAACCTGGCCGTGTTTATCAACATCATCATTGCCTTCTTCTACCCTTACATGGAGGGCGCGTCCACA GGCGTGCTGGACTCCCCTCTCATCTCATTGCTCTTCTGGATCCTCATCTGCTTCTCCATCGCGGCCCTG TTCACCAAGCGCTACAGCATCCGCCCCCTCATCGTGGCGCTCATCCTGCGCTCCATCTACTATCTGGGC ATCGGGCCCACACTCAACATCCTGGGTGCCCTCAATCTGACCAACAAGATCGTGTTTGTGGTGAGCTTC GTGGGCAACCGTGGCACCTTCATCCGGGGCTATAAGGCCATGGTCATGGACATGGAATTCCTCTACCAC GTGGGCTACATCCTGACCAGTGTCCTGGGCCTCTTTGCTCATGAGCTGTTCTACAGCATCCTGCTCTTT GACCTCATCTACCGCGAGGAGACGCTGTTCAACGTCATCAAGAGTGTGACCCGCAATGGCCGCTCCATC CTGCTGACAGCCCTGCTGGCCCTCATCCTGGTCTACCTCTTCTCCATCGTCGGCTTCCTCTTCCTCAAG GATGACTTCATTCTCGAGGTCGACCGGCTGCCCAACAACCACTCCACAGCCAGCCCCCTGGGGATGCCA CATGGAGCTGCTGCATTTGTGGACACCTGCAGTGGGGACAAGATGGACTGTGTCTCAGGGCTCTCGGTG CCTGAGGTCCTGGAAGAGGACAGGGAGCTGGACAGCACAGAGCGGGCCTGTGACACTCTGTTGATGTGC ATCGTCACTGTCATGAACCATGGGCTACGCAACGGTGGTGGCGTGGGCGACATTCTCCGCAAGCCCTCC AAAGATGAGTCTCTCTTCCCAGCCCGAGTGGTCTATGACCTCCTGTTCTTCTTCATCGTCATCATCATT GTGCTGAACCTCATCTTTGGGGTAATCATCGACACCTTCGCTGACCTGCGTAGTGAGAAGCAGAAGAAG GAGGAGATTCTTAAGACGACATGCTTCATCTGTGGTCTGGAGAGGGACAAGTTTGATAACAAGACAGTG TCATTTGAGGAACACATCAAGCTGGAGCACAACATGTGGAACTACTTGTACTTCATTGTGCTGGTCCGC GTGAAGAACAAGACCGACTACACGGGCCCTGAGAGCTACGTGGCCCAGATGATCAAGAACAAGAACCTG GACTGGTTCCCCCGGATGCGGGCCATGTCCCTTGTCAGCAATGAGGGCGAGGGGGAGCAGAATGAGATT CGGATTCTCCAGGACAAGCTCAACTCCACCATGAAGCTGGTGTCCCACCTCACTGCCCAGCTCAACGAG CTCAAGGAGCAGATGACGGAGCAGCGGAAACGCAGGCAACGCCTAGGCTTTGTGGATGTCCAGAACTGC ATTAGCCGCTGA CAAGCTTAACTAGCTAGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGAT CTGGCAGCAAATGATATCCTGGATTACAAGGATGAC
Restriction Sites	SgfI-HindIII
ACCN	NM_002224
Insert Size	8016 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_002224.3
RefSeq Size	9047 bp
RefSeq ORF	8016 bp
Locus ID	3710
UniProt ID	Q14573
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Alzheimer's disease, Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Long-term potentiation, Oocyte meiosis, Phosphatidylinositol signaling system, Taste transduction, Vascular smooth muscle contraction
MW	304.1 kDa
Gene Summary	This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

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