United States
Germany
Japan
United Kingdom
China
NUMB (NM_001005744) Human Untagged Clone
CAT＃: SC301023
NUMB (untagged)-Human numb homolog (Drosophila) (NUMB), transcript variant 2
CNY 4,496.00
CNY 9,790.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C14orf41; c14_5527; S171 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001005744 edited
GGCCACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGAT TTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCACTGTTACAATTCAA GATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCA CTTAGGACAAATGAGGAAACTGAGGCTTGGTGAAGTTACGAAACTTGTCCAAAATCACAC AACTTGTAAAGGGCACAGCCAAGATTCAGAGCCAGGCTGTAAAAATTAAAATGAACAAAT TACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATC AGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGTACC TTGGCCATGTAGAAGTTGATGAATCAAGAGGAATGCACATCTGTGAAGATGCTGTAAAAA GATTGAAAGCTGAAAGGAAGTTCTTCAAAGGCTTCTTTGGAAAAACTGGAAAGAAAGCAG TTAAAGCAGTTCTGTGGGTCTCAGCAGATGGACTCAGAGTTGTGGATGAAAAAACTAAGG ACCTCATAGTTGACCAGACGATAGAGAAAGTTTCTTTCTGTGCCCCAGACAGGAACTTTG ATAGAGCCTTTTCTTACATATGCCGTGATGGCACCACTCGTCGCTGGATCTGTCACTGCT TCATGGCTGTCAAGGACACAGGTGAAAGGTTGAGCCATGCAGTAGGCTGTGCTTTTGCAG CCTGTTTAGAGCGCAAGCAGAAGCGGGAGAAGGAATGTGGAGTGACTGCTACTTTTGATG CTAGTCGGACCACTTTTACAAGAGAAGGATCATTCCGTGTCACAACAGCCACTGAACAAG CAGAAAGAGAGGAGATCATGAAACAAATGCAAGATGCCAAGAAAGCTGAAACAGATAAGA TAGTCGTTGGTTCATCAGTTGCCCCTGGCAACACTGCCCCATCCCCATCCTCTCCCACCT CTCCTACTTCTGATGCCACGACCTCTCTGGAGATGAACAATCCTCATGCCATCCCACGCC GGCATGCTCCAATTGAACAGCTTGCTCGCCAAGGCTCTTTCCGAGGTTTTCCTGCTCTTA GCCAGAAGATGTCACCCTTTAAACGCCAACTATCCCTACGCATCAATGAGTTGCCTTCCA CTATGCAGAGGAAGACTGATTTCCCCATTAAAAATGCAGTGCCAGAAGTAGAAGGGGAGG CAGAGAGCATCAGCTCCCTGTGCTCACAGATCACCAATGCCTTCAGCACACCTGAGGACC CCTTCTCATCTGCTCCGATGACCAAACCAGTGACAGTGGTGGCACCACAATCTCCTACCT TCCAAGGGACCGAGTGGGGTCAATCTTCTGGTGCTGCCTCTCCAGGTCTCTTCCAGGCCG GTCATAGACGTACTCCCTCTGAGGCCGACCGATGGTTAGAAGAGGTGTCTAAGAGCGTCC GGGCTCAGCAGCCCCAGGCCTCAGCTGCTCCTCTGCAGCCAGTTCTCCAGCCTCCTCCAC CCACTGCCATCTCCCAGCCAGCATCACCTTTCCAAGGGAATGCATTCCTCACCTCTCAGC CTGTGCCAGTGGGTGTGGTCCCAGCCCTGCAACCAGCCTTTGTCCCTGCCCAGTCCTATC CTGTGGCCAATGGAATGCCCTATCCAGCCCCTAATGTGCCTGTGGTGGGCATCACTCCCT CCCAGATGGTGGCCAACGTATTTGGCACTGCAGGCCACCCTCAGGCTGCCCATCCCCATC AGTCACCCAGCCTGGTCAGGCAGCAGACATTCCCTCACTACGAGGCAAGCAGTGCTACCA CCAGTCCCTTCTTTAAGCCTCCTGCTCAGCACCTCAACGGTTCTGCAGCTTTCAATGGTG TAGATGATGGCAGGTTGGCCTCAGCAGACAGGCATACAGAGGTTCCTACAGGCACCTGCC CAGTGGATCCTTTTGAAGCCCAGTGGGCTGCATTAGAAAATAAGTCCAAGCAGCGTACTA ATCCCTCCCCTACCAACCCTTTCTCCAGTGACTTACAGAAGACGTTTGAAATTGAACTTT AAGCAATCATTATGGCTATGTATCTTGTCCATACCAGACAGGGAGCAGGGGGTAGCGGTC AAAGGAGCAAAACAGACTTTGTCTCCTGATTAGTACTCTTTTCACTAATCCCAAAGGTCC CAAGGAACAAGTCCAGGCCCAGAGTACTGTGAGGGGTGATTTTGAAAGACATGGGAAAAA GCATTCCTAGAGAAAAGCTGCCTTGCAATTAGGCTAAAGAAGTCAAGGAAATGTTGCTTT CTGTACTCCCTCTTCCCTTACCCCCTTACAAATCTCTGGCAACAGAGAGGCAAAGTATCT GAACAAGAATCTATATTCCAAGCACATTTACTGAAATGTAAAACACAACAGGAAGCAAAG CAATCTCCCTTTGTTTTTCAGGCCATTCACCTGCCTCCTGTCAGTAGTGGCCTGTATTAG AGATCAAGAAGAGTGGTTTGTGCTCAGGCTGGGGAACAGAGAGGCACGCTATGCTGCCAG AATTCCCAGGAGGGCATATCAGCAACTGCCCAGCAGAGCTATATTTTGGGGGAGAAGTTG AGCTTCCATTTTGAGTAACAGAATAAATATTATATATATCAAAAGCCAAAATCTTTATTT TTATGCATTTAGAATATTTTAAATAGTTCTCAGATATTAAGAAGTTGTATGAGTTGTAAG TAATCTTGCCAAAGGTAAAGGGGCTAGTTGTAAGAAATTGTACATAAGATTGATTTATCA TTGATGCCTACTGAAATAAAAAGAGGAAAGGCTGGAAGCTGCAGACAGGATCCCTAGCTT GTTTTCTGTCAGTCATTCATTGTAAGTAGCACATTGCAACAACAATCATGCTTATGACCA ATACAGTCACTAGGTTGTAGTTTTTTTTAAATAAAGGAAAAGCAGTATTGTCCTGGTTTT AAACCTATGATGGAATTCTAATGTCATTATTTTAATGGAATCAATCGAAATATGCTCTAT AGAGAATATATCTTTTATATATTGCTGCAGTTTCCTTATGTTAATCCTTTAACACTAAGG TAACATGACATAATCATACCATAGAAGGGAACACAGGTTACCATATTGGTTTGTAATATG GGTCTTGGTGGGTTTTGTTTTATCCTTTAAATTTTGTTCCCATGAGTTTTGTGGGGATGG GGATTCTGGTTTTATTAGCTTTGTGTGTGTCCTCTTCCCCCAAACCCCCTTTTGGTGAGA ACATCCCCTTGACAGTTGCAGCCTCTTGACCTCGGATAACAATAAGAGAGCTCATCTCAT TTTTACTTTTGAACGTTGGCCTTACAATCAAATGTAAGTTATATATATTTGTACTGATGA AAATTTATAATCTGCTTTAACAAAAATAAATGTTCATGGTAGAAAAAAAAAAAAAAAAAA AAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001005744 |
| Insert Size | 3500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The ORF of this clone is found to be a perfect match to NM_001005744.1. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001005744.1, NP_001005744.1 |
| RefSeq Size | 3503 bp |
| RefSeq ORF | 1812 bp |
| Locus ID | 8650 |
| UniProt ID | P49757 |
| Protein Pathways | Notch signaling pathway |
| Gene Summary | The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 5 both encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB
,Garcia-Heredia, JM;Lucena-Cacace, A;Verdugo-Sivianes, EM;Perez, M;Carnero, A;,
Clin. Cancer Res
,PubMed ID 28153862
[NUMB]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221018 | NUMB (Myc-DDK-tagged)-Human numb homolog (Drosophila) (NUMB), transcript variant 2 |
CNY 4,488.00 |
|
| RC221018L3 | Lenti ORF clone of Human numb homolog (Drosophila) (NUMB), transcript variant 2, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC221018L4 | Lenti ORF clone of Human numb homolog (Drosophila) (NUMB), transcript variant 2, mGFP tagged |
CNY 6,460.00 |
|
| RG221018 | NUMB (tGFP-tagged) - Human numb homolog (Drosophila) (NUMB), transcript variant 2 |
CNY 5,040.00 |
