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Frizzled 2 (FZD2) (NM_001466) Human Untagged Clone
CAT＃: SC127603
FZD2 (untagged)-Human frizzled family receptor 2 (FZD2)
CNY 4,216.00
CNY 7,220.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | fz-2; Fz2; fzE2; hFz2; OMOD2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001466 edited
GAATTCGGCACGAGGGGAGAGAGGGCAGCAGCGCGCGGTGTCTCCGGCTGCTCAGTCCGA CCGCGGCAAGCAAGCGGGCAGGCGCACCGCCCCCTCCCCCGCCCGGCCTCCCCAACTCTG CGGCCGCGAGTAAAGTTTGCAAAGAGGCGCGGGAGGCGGCAGCCGCAGCGAGGAGGCGGC GGGGAAGAAGCGCAGTCTCCGGGTTGGGGGCGGGGGCGGGGGGGGCGCCAAGGAGCCGGG TGGGGGGCGGCGGCCAGCATGCGGCCCCGCAGCGCCCTGCCCCGCCTGCTGCTGCCGCTG CTGCTGCTGCCCGCCGCCGGGCCGGCCCAGTTCCACGGGGAGAAGGGCATCTCCATCCCG GACCACGGCTTCTGCCAGCCCATCTCCATCCCGCTGTGCACGGACATCGCCTACAACCAG ACCATCATGCCCAACCTTCTGGGCCACACGAACCAGGAGGACGCAGGCCTAGAGGTGCAC CAGTTCTATCCGCTGGTGAAGGTGCAGTGCTCGCCCGAACTGCGCTTCTTCCTGTGCTCC ATGTACGCACCCGTGTGCACCGTGCTGGAACAGGCCATCCCGCCGTGCCGCTCTATCTGT GAGCGCGCGCGCCAGGGCTGCGAAGCCCTCATGAACAAGTTCGGTTTTCAGTGGCCCGAG CGCCTGCGCTGCGAGCACTTCCCGCGCCACGGCGCCGAGCAGATCTGCGTCGGCCAGAAC CACTCCGAGGACGGAGCTCCCGCGCTACTCACCACCGCGCCGCCGCCGGGACTGCAGCCG GGTGCCGGGGGCACCCCGGGTGGCCCGGGCGGCGGCGGCGCTCCCCCGCGCTACGCCACG CTGGAGCACCCCTTCCACTGCCCGCGCGTCCTCAAGGTGCCATCCTATCTCAGCTACAAG TTTCTGGGCGAGCGTGATTGTGCTGCGCCCTGCGAACCTGCGCGGCCCGATGGTTCCATG TTCTTCTCACAGGAGGAGACGCGTTTCGCGCGCCTCTGGATCCTCACCTGGTCGGTGCTG TGCTGCGCTTCCACCTTCTTCACTGTCACCACGTACTTGGTAGACATGCAGCGCTTCCGC TACCCAGAGCGGCCTATCATTTTTCTGTCGGGCTGCTACACCATGGTGTCGGTGGCCTAC ATCGCGGGCTTCGTGCTCCAGGAGCGCGTGGTGTGCAACGAGCGCTTCTCCGAGGACGGT TACCGCACGGTGGTGCAGGGCACCAAGAAGGAGGGCTGCACCATCCTCTTCATGATGCTC TACTTCTTCAGCATGGCCAGCTCCATCTGGTGGGTCATCCTGTCGCTCACCTGGTTCCTG GCAGCCGGCATGAAGTGGGGCCACGAGGCCATCGAGGCCAACTCTCAGTACTTCCACCTG GCCGCCTGGGCCGTGCCGGCCGTCAAGACCATCACCATCCTGGCCATGGGCCAGATCGAC GGCGACCTGCTGAGCGGCGTGTGCTTCGTAGGCCTCAACAGCCTGGACCCGCTGCGGGGC TTCGTGCTAGCGCCGCTCTTCGTGTACCTGTTCATCGGCACGTCCTTCCTCCTGGCCGGC TTCGTGTCGCTCTTCCGCATCCGCACCATCATGAAGCACGACGGCACCAAGACCGAAAAG CTGGAGCGGCTCATGGTGCGCATCGGCGTCTTCTCCGTGCTCTACACAGTGCCCGCCACC ATCGTCATCGCTTGCTACTTCTACGAGCAGGCCTTCCGCGAGCACTGGGAGCGCTCGTGG GTGAGCCAGCACTGCAAGAGCCTGGCCATCCCGTGCCCGGCGCACTACACGCCGCGCATG TCGCCCGACTTCACGGTCTACATGATCAAATACCTCATGACGCTCATCGTGGGCATCACG TCGGGCTTCTGGATCTGGTCGGGCAAGACGCTGCACTCGTGGAGGAAGTTCTACACTCGC CTCACCAACAGCCGACACGGTGAGACCACCGTGTGAGGGACGCCCCCAGGCCGGAACCGC GCGGCGCTTTCCTCCGCCCGGGGTGGGGCCCCTACAGACTCCGTATTTTATTTTTTTAAA TAAAAAACGATCGAAACCATTTCACTTTTAGGTTGCTTTTTAAAAGAGAACTCTCTGCCC AACACCCCCACAAGGTTTGTAATTAAAACTGTAAATAGTCTTTGTAAATTTAATTATATA TATTTTCTATTTAAAAGAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_001466 unedited
GGTCGGATTTTGTATACGACTTCACTATAGGGCGGCCGCGATTCGGCACGAGGGGAGAGA GGGCAGCAGCGCGCGGTGTCTCCGGCTGCTCAGTCCGACCGCGGCAAGCAAGCGGGCAGG CGCACCGCCCCCTCCCCCGCCCGGCCTCCCCAACTCTGCGGCCGCGAGTAAAGTTTGCAA AGAGGCGCGGGAGGCGGCAGCCGCAGCGAGGAGGCGGCGGGGAAGAAGCGCAGTCTCCGG GTTGGGGGCGGGGGCGGGGGGGGCGCCAAGGAGCCGGGTGGGGGGGCGGNNNNNNNNNTN TNNNTTNTNNNNNNNNTTTNNTNTTNNTTTTTTTGTNTTTTNTNTTTTTTTTTTTTTTNN NTTNNNNNNNTTTNTTTNNNNTTGGNNNTTTTNNTTNTTNNTTTTTTTTTTTNTTTTNNN TTNNTTTTTTTTTTTTTNNTTTTTTTTTTTTTNNTTTTTTNNNTTTTTTTTTTTTTTTTT TTTTNTTNNTNNTTTNNTTTTTTTTTTTTTTTNTNTTNTTNNTTTTTNNNNNTTNTTTTT TTTTTTTTTTTTTTTTTTTTNTTTTTTTTTTGGTTTTTTTTTTTTTTTTTTNNNTTTTTC CTTTTTTTTTNTTTTTTTTTTTNTTTTTTTTTNNTTTTTTTTNTTTTTTTTTTTTTTTTT TCTTTTTTTTTNTNNTTNTTTTTTTTTTTTTTTNNNNTTNNTTTTNTTTTTTTTTTTNTT TTTTNTTTTTTTNNTNTTTTTTTTTTTTTTTTTTTTTTTTNTTTNNTTTNNTTTTTTTTT TTTTTTTTTTTTNNTTTTTTTTTTTTNNNTTTTTTTTNNTTTTTTTTTTTTTTTNTTTTN TNNTTTNNNTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTNTTTNTTTTTTTTTTTTTNNT TNNNTTTTTTTTCCTCCTTTTTTTTTTT >OriGene 3' read for NM_001466 unedited
CGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTCTTTTAAATAGAAAATATAT ATAATTAAATTTACAAAGACTATTTACAGTTTTAATTACAAACCTTGTGGGGGTGTTGGG CAGAGAGTTCTCTTTTAAAAAGCAACCTAAAAGTGAAATGGTTTCGATCGTTTTTTATTT AAAAAAATAAAATACGGAGTCTGTAGGGGCCCCACCCCGGGCGGAGGAAAGCGCCGCGCG GTTCCGGCCTGGGGGCGTCCCTCACACGGTGGTCTCACCGTGTCGGCTGTTGGTGAGGCG AGTGTAAAACTTCCTCCACGAGTGCAGCGTCTTGCCCGACCAGATCCAGAAGCCCGACGT GATGCCCACGATGAGCGTCATGAGGTATTTGATCATGTAGACCGTGAAGTCGGGCGACAT GCGCGGCGTGTAGTGCGCCGGGCACGGGATGGCCAGGCTCTTGCAGTGCTGGCTCACCCA CGAGCGCTTCCAGTGCTCGCGGAAGGCCTGCTCGTAAAAGTAGCAAGCGATGACGATGGT GGGCGGCACTGTGTAGAGCACGGAGAAGACGCCGATGCGCACCATGAGCCCGCTCAGCTT TTCGGTCTTGGTGCCGTCGTGCTTCATGATGGGTGCGATGCCGAAGAGCGACACGAAGCC GCCCAGAGGAAGACGTGCCCATGACAAGTACACGAAGAAGCGCGCTAGCACGAACCCCGC AGGGGTCCAGCCTGTTGAGCCTACGAGCACACGCCGTTCACAAGTCGCCGTCATCTGCCA TGGCCAGATGGGATTGTCTTGAAGCGGCCGCCCAGGCGGCAGGGGAGTACTGAAGTTGCC CTCATTGCTCGTGGCCCACTTATGCCGGTTGCGGAACCCGGTGAGGAAGGATGACCCACA ATGAGCTGCCTGCTGAAAAGTAACCTCTGAAAGGATGGGCCCCCTTTTTTTGGCCCTGCC CACGGCGGGAACCGTCTGGAAAAGCTGTTGCACCCCCCCTTCGGAACCAAACCG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001466 |
| Insert Size | 2170 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001466.2, NP_001457.1 |
| RefSeq Size | 1983 bp |
| RefSeq ORF | 1698 bp |
| Locus ID | 2535 |
| UniProt ID | Q14332 |
| Domains | FRI, Frizzled |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway |
| Gene Summary | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled
,Wesslowski, J;Kozielewicz, P;Wang, X;Cui, H;Schihada, H;Kranz, D;Karuna M, P;Levkin, P;Gross, JC;Boutros, M;Schulte, G;Davidson, G;,
J. Biol. Chem.
,PubMed ID 32381507
[FZD2]
|
|
Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
,Voloshanenko, O;Gmach, P;Winter, J;Kranz, D;Boutros, M;,
FASEB J.
,PubMed ID 28733458
[FZD2]
|
|
ß-Catenin-dependent pathway activation by both promiscuous canonical WNT3a-, and specific noncanonical WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency
,Ring, L;Neth, P;Weber, C;Steffens, S;Faussner, A;,
Cell. Signal.
,PubMed ID 24269653
[FZD2]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220921 | FZD2 (Myc-DDK-tagged)-Human frizzled family receptor 2 (FZD2) |
CNY 3,990.00 |
|
| RC220921L1 | Lenti ORF clone of Human frizzled family receptor 2 (FZD2), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC220921L2 | Lenti ORF clone of Human frizzled family receptor 2 (FZD2), mGFP tagged |
CNY 5,890.00 |
|
| RC220921L3 | Lenti ORF clone of Human frizzled family receptor 2 (FZD2), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC220921L4 | Lenti ORF clone of Human frizzled family receptor 2 (FZD2), mGFP tagged |
CNY 5,890.00 |
|
| RG220921 | FZD2 (tGFP-tagged) - Human frizzled family receptor 2 (FZD2) |
CNY 4,370.00 |
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