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PPM1D (BC042418) Human Untagged Clone
CAT＃: SC126023
PPM1D (untagged)-Human protein phosphatase 1D magnesium-dependent, delta isoform, mRNA (cDNA clone MGC:35090 IMAGE:5167004), complete cds
CNY 2,950.00
货期*
现货
规格
Product images
经常一起买 (4)
PPM1D mouse monoclonal antibody,clone OTI3E1
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | p53-induced protein phosphatase 1; PP2C-DELTA; protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 2C delta isoform; protein phosphatase Wip1; WIP1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for BC042418 edited
CGCGCCCCCCCTTCTCCGGGTCCGCCCCCTCCCCCTTCTCGGCGTCGTCGAAGATAAACA ATAGTTGGCCGGCGAGCGCCTAGTGTGTCTCCCGCCGCCGGATTCGGCGGGCTGCGTGGG ACCGGCGGGATCCCGGCCAGCCGGCCATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCT TCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAGCCCG AACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGC GGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAG CCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGCTGCT GCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGG CGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCT CGTCCGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTG CCATGTGGAAGAAACTGGCGGAATGGCCAAAGACTATGACGGGTCTTCCTAGCACATCAG GGACAACTGCCAGTGTGGTCATCATTCGGGGCATGAAGATGTATGTAGCTCACGTAGGTG ACTCAGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCTGTGG AGGTGACACAGGACCATAAGCCAGAACTTCCCAAGGAAAGAGAACGAATCGAAGGACTTG GTGGGAGTGTAATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTCGACTCA CTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCAGTAG CAAGAGCACTTGGTGATTTGTGGAGCTATGATTTCTTCAGTGGTGAATTTGTGGTGTCAC CTGAACCAGACACAAGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTATATTGG GGAGTGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAGGACC AAGAGGAGAAAAAATACCTGATGGGTGAGCATGGACAATCTTGTGCCAAAATGCTTGTGA ATCGAGCATTGGGCCGCTGGAGGCAGCGTATGCTCCGAGCAGATAACACTAGTGCCATAG TAATCTGCATCTCTCCAGAAGTGGACAATCAGGGAAACTTTACCAATGAAGATGAGTTAT ACCTGAACCTGACTGACAGCCCTTCCTATAATAGTCAAGAAACCTGTGTGATGACTCCTT CCCCATGTTCTACACCACCAGTCAAGGATTTTGGATTTGAACTCGATTCAAGAAAGTGAT GTAACTTATTATCAGAGAGCCATCTTTACATCAATACTAATCTGAATGCCAGCCATGTGT ACAGCACTAATAAAAAGTCACTGGAGGAGGATCCATGGCCAAGGGTGAATTCTAAGGACC ATATACCTGCCCTGGTTCGTAGCAATGCCTTCTCAGAGAATTTTTTAGAGGTTTCAGCTG AGATAGCTCGAGAGAATGTCCAAGGTGTAGTCATACCCTCAAAAGATCCAGAACCACTTG AAGAAAATTGCGCTAAAGCCCTGACTTTAAGGATACATGATTCTTTGAATAATAGCCTTC CAATTGGCCTTGTGCCTACTAATTCAACAAACACTGTCATGGACCAAAAAAATTTGAAGA TGTCAACTCCTGGCCAAATGAAAGCCCAAGAAATTGAAAGAACCCCTCCAACAAACTTTA AAAGGACATTAGAAGAGTCCAATTCTGGCCCCCTGATGAAGAAGCATAGACGAAATGGCT TAAGTCGAAGTAGTGGTGCTCAGCCTGCAAGTCTCCCCACAACCTCACAGCGAAAGAACT CTGTTAAACTCACCATGCGACGCAGACTTAGGGGCCAGAAGAAAATTGGAAATCCTTTAC TTCATCAACACAGGAAAACTGTTTGTGTTTGCTGAAATGCATCTGGGAAATGAGGTTTTT CCAAACTTAGGATATAAGAGGGCTTTTTAAATTTGGTGCCGATGTTGAACTTTTTTTAAG GGGAGAAAATTAAAAGAAATATACAGTTTGACTTTTTGGAATTCAGCAGTTTTATCCTGG CCTTGTACTTGCTTGTATTGTAAATGTGGATTTTGTAGATGTTAGGGTATAAGTTGCTGT AAAATTTGTGTAAATTTGTATCCACACAAATTCAGTCTCTGAATACACAGTATTCAGAGT CTCTGATACACAGTAATTGTGACAATAGGGCTAAATGTTTAAAGAAATCAAAAGAATCTA TTAGATTTTAGAAAAACATTTAAACTTTTTAAAATACTTATTAAAAAATTTGTATAAGCC ACTTGTCTTGAAAACTGTGCAACTTTTTAAAGTAAATTATTAAGCAGACTGGAAAAGTGA TGTATTTTCATAGTGACCTGTGTTTCACTTAATGTTTCTTAGAGCCAAGTGTCTTTTAAA CATTATTTTTTATTTCTGATTTCATAATTCAGAACTAAATTTTTCATAGAAGTGTTGAGC CATGCTACAGTTAGTCTTGTCCCAATTAAAATACTATGCAGTATCTCTTACATCAGTAGC ATTTTTCTAAAACCTTAGTCATCAGATATGCTTACTAAATCTTCAGCATAGAAGGAAGTG TGTTTGCCTAAAACAATCTAAAACAATTCCCTTCTTTTTCATCCCAGACCAATGGCATTA TTAGGTCTTAAAGTAGTTACTCCCTTCTCGTGTTTGCTTAAAATATGTGAAGTTTTCCTT GCTATTTCAATAACAGATGGTGCTGCTAATTCCCAACATTTCTTAAATTATTTTATATCA TACAGTTTTCATTGATTATATGGGTATATATTCATCTAATAAATCAGTGAACTGTTAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAA >OriGene 5' read for BC042418 unedited
ATTTGTATACGACTTTTATAGGCGGCCGCGAATTCAGATCTGGTACCGGTCCGGAATTCC CGGGATCGCGCCCCCCCTTCTCCGGGTCCGCCCCCTCCCCCTTCTCGGCGTCGTCGAAGA TAAACAATAGTTGGCCGGCGAGCGCCTAGTGTGTCTCCCGCCGCCGGATTCGGCGGGCTG CGTGGGACCGGCGGGATCCCGGCCAGCCGGCCATGGCGGGGCTGTACTCGCTGGGAGTGA GCGTCTTCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGG AGCCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCGGTCGCTGTCTCAGCCGTTGC CTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGG TGGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCC GCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGC GGGAGGCGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTT TCACCTCGTCCGAGCCGGGCTAAGGTTGCGCTGCCATCCCGCAAGGGCTTTCTCGCTTGT CACCTTGCCCTGGTGAAGAAAACTGGGCGATGGCCAAAGACTATGAACGGGTCTCCTTAC ACATCAGGGGACAACTGCCAGTGTGGTCATCATTCGGGCCTGAAAATGTATGTAACTCAC TTAGTGACTCAGGGTGGGTCTTGGAATCCAGATGAACCGAGGAGAATTTGTCAAAACTGG GGGGGGGCCCAGGACCTTAACCCAACCTCCCAGGAAGAAAACAAATCAAGGCTTGGTGGG GGTAATGAACAATTGGGGGAACCGGTATTTGGAACCACTCCCTCCT |
| Restriction Sites | NotI-NotI |
| ACCN | BC042418 |
| Insert Size | 3100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | BC042418.1, AAH42418.1 |
| RefSeq Size | 3070 bp |
| Locus ID | 8493 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | p53 signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] |
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