United States
Germany
Japan
United Kingdom
China
CD46 (NM_172361) Human Untagged Clone
CAT＃: SC124792
CD46 (untagged)-Human CD46 molecule, complement regulatory protein (CD46), transcript variant l
CNY 5,700.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AHUS2; MCP; MIC10; TLX; TRA2.10 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_172361, the custom clone sequence may differ by one or more nucleotides
ATGGAGCCTCCCGGCCGCCGCGAGTGTCCCTTTCCTTCCTGGCGCTTTCCTGGGTTGCTTCTGGCGGCCA TGGTGTTGCTGCTGTACTCCTTCTCCGATGCCTGTGAGGAGCCACCAACATTTGAAGCTATGGAGCTCAT TGGTAAACCAAAACCCTACTATGAGATTGGTGAACGAGTAGATTATAAGTGTAAAAAAGGATACTTCTAT ATACCTCCTCTTGCCACCCATACTATTTGTGATCGGAATCATACATGGCTACCTGTCTCAGATGACGCCT GTTATAGAGAAACATGTCCATATATACGGGATCCTTTAAATGGCCAAGCAGTCCCTGCAAATGGGACTTA CGAGTTTGGTTATCAGATGCACTTTATTTGTAATGAGGGTTATTACTTAATTGGTGAAGAAATTCTATAT TGTGAACTTAAAGGATCAGTAGCAATTTGGAGCGGTAAGCCCCCAATATGTGAAAAGGTTTTGTGTACAC CACCTCCAAAAATAAAAAATGGAAAACACACCTTTAGTGAAGTAGAAGTATTTGAGTATCTTGATGCAGT AACTTATAGTTGTGATCCTGCACCTGGACCAGATCCATTTTCACTTATTGGAGAGAGCACGATTTATTGT GGTGACAATTCAGTGTGGAGTCGTGCTGCTCCAGAGTGTAAAGTGGTCAAATGTCGATTTCCAGTAGTCG AAAATGGAAAACAGATATCAGGATTTGGAAAAAAATTTTACTACAAAGCAACAGTTATGTTTGAATGCGA TAAGGGTTTTTACCTCGATGGCAGCGACACAATTGTCTGTGACAGTAACAGTACTTGGGATCCCCCAGTT CCAAAGTGTCTTAAAGGATATCCTAAACCTGAGGAAGGAATACTTGACAGTTTGGATGTTTGGGTCATTG CTGTGATTGTTATTGCCATAGTTGTTGGAGTTGCAGTAATTTGTGTTGTCCCGTACAGATATCTTCAAAG GAGGAAGAAGAAAGGGAAAGCAGATGGTGGAGCTGAATATGCCACTTACCAGACTAAATCAACCACTCCA GCAGAGCAGAGAGGCTGA >OriGene 5' read for NM_172361 unedited
ATTTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTGGATGCTTTGT GAGTTGGGGATTGTTGCGTCCCATATCTGGACCCAGAAGGGACTTCCCTGCTCGGCTGGC TCTCGGTTTCTCTGCTTTCCTCCGGAGAAATAACAGCGTCTTCCGCGCCGCGCATGGAGC CTCCCGGCCGCCGCGAGTGTCCCTTTCCTTCCTGGCGCTTTCCTGGGTTGCTTCTGGCGG CCATGGTGTTGCTGCTGTACTCCTTCTCCGATGCCTGTGAGGAGCCACCAACATTTGAAG CTATGGAGCTCATTGGTAAACCAAAACCCTACTATGAGATTGGTGAACGAGTAGATTATA AGTGTAAAAAAGGATACTTCTATATACCTCCTCTTGCCACCCATACTATTTGTGATCGGA ATCATACATGGCTACCTGTCTCAGATGACGCCTGTTATAGAGAAACATGTCCATATATAC GGGATCCTTTAAATGGCCAAGCAGTCCCTGCAAATGGGACTTACGAGTTTGGTTATCAGA TGCACTTTATTTGTAATGAGGGTTATTACTTAATTGGTGAAGAAATTCTATATTGTGAAC TTAAAGGATCAGTAGCAATTTGGAGCGGTAAGCCCCCAATATGTGAAAAGGTTTTGTGTA CACCACCTCCAAAAATAAAAAATGGAAAACACACCTTTAGTGAAGTAGAAGTATTTGAGT ATCTTGATGCAGTAACTTATANGTTGTGATCCTGCACCTGGACCAGATCCATTNTCACTT ATTGGAGAGAGCACGATTTATTGTGGTGACCATTCAGTGTGGGAGTCGTGCTGCTCCAGA GTGGTAAGTGGTCAAATGTCGATTTCCAGTAGTCGAAAATGGGAAACAGATATCAGGATT TGGAAAAAATTTACTACAAG >OriGene 3' read for NM_172361 unedited
CGTAAGAGCCATTGGGCGATGGTCAACTTGCCAGGTCACGGGGAAGAGCACTGGGGGNAG GGGCTCACAGGGCATGCCACCCGGGTATCTGTTCAGGAAAACAGCTATGACCGCGGCCGC AATCTAGAGTCGAGTTTTTTTTTTTTTTTCTTTCCAAATGTACAATTTTATTTTAACAGA TTTCAAGAGTCCATTTTTTAAAAAATGAGCAATAAAGAACCTCTATCAGTGAGACTTCTC ATTTTATAGCAAATACATTTTTGCAGCTTAAATTTTCTTGAATTCATATACGCTTCTGTC ATTTAAACAAACTTCCAGAGAAAACTGGTCTCTATATATTTAAGTAACAAATTTGACAAA ATACATATTTATACATATATAGATCTCTAATATAAATATTAAATTTGAAAAAATCAAATG TGAAGCAGAAACTGCTATACAAGTATATTGTATAATATTTATTTTATACATTAAAGTATT TGGTTGAATATACTTCAATTAGGTTTCTAAAAAACACCATTATCTGCTTCTTAGTAATTG CGACATTCTTGAAAAGCATGTGAAACGGGTATAAACTTCAACTCTGTGCTTAATTCAAAA TTCCTGTTTGTTCTCCTCAAACTTTTATCTTCCTAAAGCATCTTGCCAGAGACTACAAAG GAAAGGAACATTTACAGAGCACTATAAACATGTCTTTGGACAGTAAAACAGTATTTATTC TTCTACACTCTTGATTTTCCAATCATATCTTCCTCAAGGCAATGTTTCTTTGGCCCAATT TGTGCAACTAAACATAAAATTTCAAAACACAACTTTTAACAGTGTGATATGAAATGCAGT GGCAGTCCCTGCTTTTCGCCTGCTGGCTTCTTTGAAAGATACTGCTTGGCTANAGGACTC AGTANAGGGCTGANATCTGCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_172361 |
| Insert Size | 3800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_172361.1, NP_758871.1 |
| RefSeq Size | 3177 bp |
| RefSeq ORF | 3177 bp |
| Locus ID | 4179 |
| UniProt ID | P15529 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Complement and coagulation cascades |
| Gene Summary | The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] Transcript Variant: This variant (l) lacks an alternate in-frame segment and an exon containing the stop codon as compared to variant a. The resulting isoform (12) is shorter and has a distinct C-terminus compared to isoform 1. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221320 | CD46 (Myc-DDK-tagged)-Human CD46 molecule, complement regulatory protein (CD46), transcript variant l |
CNY 3,990.00 |
|
| RC221320L3 | Lenti-ORF clone of CD46 (Myc-DDK-tagged)-Human CD46 molecule, complement regulatory protein (CD46), transcript variant l |
CNY 5,890.00 |
|
| RC221320L4 | Lenti-ORF clone of CD46 (mGFP-tagged)-Human CD46 molecule, complement regulatory protein (CD46), transcript variant l |
CNY 5,890.00 |
|
| RG221320 | CD46 (tGFP-tagged) - Human CD46 molecule, complement regulatory protein (CD46), transcript variant l |
CNY 4,370.00 |
