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FGFR1 (NM_023105) Human Untagged Clone
CAT＃: SC124203
FGFR1 (untagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3
CNY 8,064.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_023105, the custom clone sequence may differ by one or more nucleotides
ATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGT CCCCGACCTTGCCTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTC AGAGGAGAAAGAAACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAA AAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGA CCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTA CAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACC TGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTC ACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCAT GTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAG ATTGGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGA TGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTC TATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATG ACCTCGCCCCTGTACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGT CGGTCATCGTCTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAA GCTGGCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACTCT GGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGT ATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGA GGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACC AAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGG AGATGATGAAGATGATCGGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCC CTTGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCA GGGCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCT GCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGC CAGGAATGTCCTGGTGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCAC CACATCGACTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTAT TTGACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCT GGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATG GACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCAC AGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTA CCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCC TCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCC AGCTTGCCAATGGCGGACTCAAACGCCGCTGA >OriGene 5' read for NM_023105 unedited
NGGGTTGCCCTTTTGTATACGACTCATATAGGCGGCCGCGTAATTCGCACGAGGCTTGCG GCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCGGTGC AGCCGCAGCGCGCGGAGGAACCTGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGG ACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGGCCGCGAGCGCGCCGC TGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCA GGGCGCACGGTACCCGTGCTGCAGTCGGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCG ATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGAGGGGGGCA CAAGGTCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGGGGCA CCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGCACCGAGCGCCGCCGG GAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGG GCGGCGGGCCGGAGCCGGGGACGCGGGCACACGCCCGCTCGCACAAGCCACGGCGGACTC TCCCGAGGCGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCAC TGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGAT GTGGAGCTGGAAGTGCCTNCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGC TAGGCCGTNCCCGACCTTGCCTNGACAAGCCAGCCCCTGGGAGCCCTGTGGAAGTGGAGT NCTTNCTGGGTCACCCGC >OriGene 3' read for NM_023105 unedited
CTATGGCCGCGGCCGCATCTATGATCGGTTTTTTTTTTTTTTTTTTCAATTTCACTGTCT TTTATTTGACAGCTAGCGCAGTCTTTGGGGAAATTTGTGGGTGATTTGAGTAGTAACAGC AAGGACATCACTGTAATTATGATAGTGCCTTATATTTTTCTAGCACCTCTCCCAAGGACT TATGAAGACTTTTAGATTCTTCATCCCTTCACACAACATTGCTTCAAGGTAGGGCCAAGG CAGAAATTATCATCACTGTTTTACAAGGAAAGACACTCCTGTGCGGTCTCAAAGCAAATG CTTTTAAGAGCTAAAAATTCATTTCCTAGTTCTGTTCACCAAATGATGCCTTCTTTAAAC ATAAATACAAATTGTAATGTTAGCAGGTGCTATTTACAGAGAGAAACAAAGAGAATTTTA CAATAGTCGCCAACACTGCAGCTGCCAAAAAATCCCTAGCTCAGAAATTTAAAGCAGCAA TCCCATTTTCCCTACAGAAATGAAAACATATTGAACTTTCTTTTGTATTTAGCAGTAATC CAGCAAAATATAAGCTTTAATATAGCGACTGAGGAGTGGTAGTTTGAGCCATGAGGTACG GGGGAGCCAGAATCCACTTATTGAGGACAGTGATGACCAGCAGGTGGCAGAAGTAAATTC CAAGCAGCCAAAAAACCAAAAACATCTCGGAGAATTTTCCCCCCGTTCCTGAGGGACAGG ATGGGAGTTTGGACAGGAAGAACTGTAAGAAGCCAAGATCTGCGACAGTCCCAACAAATA CAGTCTGGTCACATGGATACAGGAATGGACGATCTTGNGGAGGTCATACCAACAAGAAAC GAAGCCAGGGACCTCGATGCAAACTAGCCTCAGTGACATGTTCTCCTGACTTAAAGCACT GGCAAAACCTGCCACCTAAAGGGGCAGACCATGTCTGGGGTTTCAGTTCTGCAACCTAAT CATCGTTTCCTTCTTGGTTTCTTGTGGCCAGCG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_023105 |
| Insert Size | 5410 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_023105.1, NP_075593.1 |
| RefSeq Size | 5650 bp |
| RefSeq ORF | 2202 bp |
| Locus ID | 2260 |
| UniProt ID | P11362 |
| Domains | pkinase, TyrKc, S_TKc, ig, IGc2, IG |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
| Gene Summary | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210629 | FGFR1 (Myc-DDK-tagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 8,592.00 |
|
| RC210629L1 | Lenti-ORF clone of FGFR1 (Myc-DDK-tagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 10,992.00 |
|
| RC210629L2 | Lenti-ORF clone of FGFR1 (mGFP-tagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 5,890.00 |
|
| RC210629L3 | Lenti-ORF clone of FGFR1 (Myc-DDK-tagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 5,890.00 |
|
| RC210629L4 | Lenti-ORF clone of FGFR1 (mGFP-tagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 5,890.00 |
|
| RC600020 | FGFR1 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens fibroblast growth factor receptor 1, transcript variant 3, Signal peptide (1-21) plus EC domain (22-287) |
CNY 2,400.00 |
|
| RG210629 | FGFR1 (tGFP-tagged) - Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 10,192.00 |
|
| SC322767 | FGFR1 (untagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 3 |
CNY 8,064.00 |
