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MASP1 (NM_001879) Human Untagged Clone
CAT＃: SC123994
MASP1 (untagged)-Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1
CNY 5,128.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | 3MC1; CRARF; CRARF1; MAP-1; MAP1; MAp44; MASP; MASP-3; MASP3; PRSS5; RaRF |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC123994 sequence for NM_001879 edited (data generated by NextGen Sequencing)
ATGAGGTGGCTGCTTCTCTATTATGCTCTGTGCTTCTCCCTGTCAAAGGCTTCAGCCCAC ACCGTGGAGCTAAACAATATGTTTGGCCAGATCCAGTCGCCTGGTTATCCAGACTCCTAT CCCAGTGATTCAGAGGTGACTTGGAATATCACTGTCCCAGATGGGTTTCGGATCAAGCTT TACTTCATGCACTTCAACTTGGAATCCTCCTACCTTTGTGAATATGACTATGTGAAGGTA GAAACTGAGGACCAGGTGCTGGCAACCTTCTGTGGCAGGGAGACCACAGACACAGAGCAG ACTCCCGGCCAGGAGGTGGTCCTCTCCCCTGGCTCCTTCATGTCCATCACTTTCCGGTCA GATTTCTCCAATGAGGAGCGTTTCACAGGCTTTGATGCCCACTACATGGCTGTGGATGTG GACGAGTGCAAGGAGAGGGAGGACGAGGAGCTGTCCTGTGACCACTACTGCCACAACTAC ATTGGCGGCTACTACTGCTCCTGCCGCTTCGGCTACATCCTCCACACAGACAACAGGACC TGCCGAGTGGAGTGCAGTGACAACCTCTTCACTCAAAGGACTGGGGTGATCACCAGCCCT GACTTCCCAAACCCTTACCCCAAGAGCTCTGAATGCCTGTATACCATCGAGCTGGAGGAG GGTTTCATGGTCAACCTGCAGTTTGAGGACATATTTGACATTGAGGACCATCCTGAGGTG CCCTGCCCCTATGACTACATCAAGATCAAAGTTGGTCCAAAAGTTTTGGGGCCTTTCTGT GGAGAGAAAGCCCCAGAACCCATCAGCACCCAGAGCCACAGTGTCCTGATCCTGTTCCAT AGTGACAACTCGGGAGAGAACCGGGGCTGGAGGCTCTCATACAGGGCTGCAGGAAATGAG TGCCCAGAGCTACAGCCTCCTGTCCATGGGAAAATCGAGCCCTCCCAAGCCAAGTATTTC TTCAAAGACCAAGTGCTCGTCAGCTGTGACACAGGCTACAAAGTGCTGAAGGATAATGTG GAGATGGACACATTCCAGATTGAGTGTCTGAAGGATGGGACGTGGAGTAACAAGATTCCC ACCTGTAAAATTGTAGACTGTAGAGCCCCAGGAGAGCTGGAACACGGGCTGATCACCTTC TCTACAAGGAACAACCTCACCACATACAAGTCTGAGATCAAATACTCCTGTCAGGAGCCC TATTACAAGATGCTCAACAATAACACAGGTATATATACCTGTTCTGCCCAAGGAGTCTGG ATGAATAAAGTATTGGGGAGAAGCCTACCCACCTGCCTTCCAGTGTGTGGGCTCCCCAAG TTCTCCCGGAAGCTGATGGCCAGGATCTTCAATGGACGCCCAGCCCAGAAAGGCACCACT CCCTGGATTGCCATGCTGTCACACCTGAATGGGCAGCCCTTCTGCGGAGGCTCCCTTCTA GGCTCCAGCTGGATCGTGACCGCCGCACACTGCCTCCACCAGTCACTCGATCCGGAAGAT CCGACCCTACGTGATTCAGACTTGCTCAGCCCTTCTGACTTCAAAATCATCCTGGGCAAG CATTGGAGGCTCCGGTCAGATGAAAATGAACAGCATCTCGGCGTCAAACACACCACTCTC CACCCCCAGTATGATCCCAACACATTCGAGAATGACGTGGCTCTGGTGGAGCTGTTGGAG AGCCCAGTGCTGAATGCCTTCGTGATGCCCATCTGTCTGCCTGAGGGACCCCAGCAGGAA GGAGCCATGGTCATCGTCAGCGGCTGGGGGAAGCAGTTCTTGCAAAGGTTCCCAGAGACC CTGATGGAGATTGAAATCCCGATTGTTGACCACAGCACCTGCCAGAAGGCTTATGCCCCG CTGAAGAAGAAAGTGACCAGGGACATGATCTGTGCTGGGGAGAAGGAAGGGGGAAAGGAC GCCTGTGCGGGTGACTCTGGAGGCCCCATGGTGACCCTGAATAGAGAAAGAGGCCAGTGG TACCTGGTGGGCACTGTGTCCTGGGGTGATGACTGTGGGAAGAAGGACCGCTACGGAGTA TACTCTTACATCCACCACAACAAGGACTGGATCCAGAGGGTCACCGGAGTGAGGAACTGA Clone variation with respect to NM_001879.5 >OriGene 5' read for NM_001879 unedited
CCAAATTTTGTAATACGACTCACTATAGGGCGGCNCGCGATTCGGCACGAGACCGGGCAC GAGCTCACAGGCAAGTCAAGCTGGGAGGACCAAGGCCGGGCAGCCGGGAGCACCCAAGGC AGGAAAATGAGGTGGCTGCTTCTCTATTATGCTCTGTGCTTCTCCCTGTCAAAGGCTTCA GCCCACACCGTGGAGCTAAACAATATGTTTGGCCAGATCCAGTCGCCTGGTTATCCAGAC TCCTATCCCAGTGATTCAGAGGTGACTTGGAATATCACTGTCCCAGATGGGTTTCGGATC AAGCTTTACTTCATGCACTTCAACTTGGAATCCTCCTACCTTTGTGAATATGACTATGTG AAGGTAGAAACTGAGGACCAGGTGCTGGCAACCTTCTGTGGCAGGGAGACCACAGACACA GAGCAGACTCCCGGCCAGGAGGTGGTCCTCTCCCCTGACTCCTTCATGTCCATCACTTTC CGGTCAGATTTCTCCAATGAGGAGCGTTTCACAGGCTTTGATGCCCACTACATGGCTGTG GATGTGGACGAGTGCAAGGAGAGGGAGGACGAGGAGCTGTCCTGTGACCCCTACTGCCAC AACTACATTGGCGGGCTACTACTGCTCCTGCCCGCTTCGGCTACATTCTTCCAACAGAAC ACAAGACCTGCCGAAGTGGATGCCATGGCAACCCTCCTCACTTCAAGGACTGGGGTGGAT CACAGCCCTGACTTCCCAAACCCTAACCCCAAAAGCCTTGAATCCTTGTTACCACTCAAG CTGAGGGAGGTTTCAGGGGCAAACCGGAAGTGTAGAAAATTTTTGACATTGGAGGCACAC CCGGAGGGGCCCGGCCCGAGGAAATCTTAAGATCAAAAGTTGGGCCAAAATTTGGGGCCC TTTTTTGGGAAAAAACCCTAAACACATCAGCACAATAACCAGGTTCT >OriGene 3' read for NM_001879 unedited
TCCGGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGG AAACAGCTATGACCGCGGCCGCAATCTAGAGCCGAGTTTTTTTTTTTTTTTTTTGTCTGT TTTACTTTTTTAGGGATGAGGGTGAAGATTGATGTTGGGCAAGTTGCACGGTGGCAAAAA AGCATACAGCATTTAAGGGCAGATGGAGATGGTCAAGGTTGAGGGGAGAGGTGTGTCACT GATCAATGCTAAGACCCAGGCAGGGGTTTGTAAGAGAGCTTCGTCTGCCTGGTAGACACA TCGACCTTCTGCTAAGGTGCATTTATTGAAAACAGTGTATGCTATGCACTCTGTTAAGTG CTATGCATCTATTAGTTAATCTTTTCCTCATCAGACTTTTACGAGGTAGGTAAGGTATAG CGTTTCCATCTTATGAAGAAACTGAAGTTCGAAGAGATGAAGTCACCTGCCCAGCACTGC AAACTAGTAAGTGATAGAGCCTGGATTCGGCCTGTGTTCTGACCACTCTCTTGCTGCATC TCTTTAAAGAGAGTGGAAAGGGGGTGAAGATACCTGCTCTATTGCCCAGTAATGGATAGG CCCAAGGAGGGTGAATGGGAGGAAAGAAAGTGAAAACTACGTGCTGCCCGAGGGGGAGCC ACCAACGGAGAATGGGCCGCACCACCTGGGGCACTTGGGCCCCAAGAACCCTGTGCTTTG TGTAGCTACATAATAAAGCG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001879 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001879.4, NP_001870.3 |
| RefSeq Size | 4353 bp |
| RefSeq ORF | 2100 bp |
| Locus ID | 5648 |
| UniProt ID | P48740 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Complement and coagulation cascades |
| Gene Summary | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. This isoform (1) is referred to as MASP1 in the literature. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC219651 | MASP1 (Myc-DDK-tagged)-Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1 |
CNY 5,120.00 |
|
| RC219651L1 | Lenti ORF clone of Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1, Myc-DDK-tagged |
CNY 9,310.00 |
|
| RC219651L2 | Lenti ORF clone of Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1, mGFP tagged |
CNY 9,310.00 |
|
| RC219651L3 | Lenti ORF clone of Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1, Myc-DDK-tagged |
CNY 9,310.00 |
|
| RC219651L4 | Lenti ORF clone of Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1, mGFP tagged |
CNY 9,310.00 |
|
| RG219651 | MASP1 (tGFP-tagged) - Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 1 |
CNY 6,720.00 |
