GSTM3 (BC030253) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	GST5; GSTB; GSTM3-3; GTM3
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC030253 edited CCACGCGTCCGGAGATAGGCCTGTGGGCCAGATTGCCATCCCCTATGGACCAGAAGCCAA GGATCTCTCTAGTGATGGTCAGAGGGCCCAAATGGCAGGGATACCCAGTGATGTCAGGAG GAATAGTACAGACAGAAGGTGCTAAGCAGACAATTCAACTGCCATGTTTTGCCACCCCCT GTGAGCAGGGATTAGGTGTTCAGGCCAGTATCTTGGGCATGGGGGAGCCTTTGGCCAGAA GAGGTATAAAGCTCAGAAGTTTTTCAGTCTGATAACTATTGATATAATTTCCATAGTGTG AGGGAGCGGTATGCTCTACCCTTGTGTATTTAAGGCAGGACAGAGAAATTGAGGATGCCC CTGGGGCTAGATCGATGATATGACCAGAAATCAAAAAGGGAACGCATTATTTATTGCTGT GTAACACTGTTAAGAGAGGAGGTAGTTAAGGGATGGATAGGCACATAGAGAGGGAAGGTC TCAGGAGAAGGGATAGAAAGGAACTATGTTCACAAGAACAACGGCAAGACAGTGCCTATA CTGCCTCTACAGTTAATAGGAAAAACGGAAGAAGTTACCCTTAAGCTAGGATGTTGCTCA GAAGTGACCATCCCAACTTTGGTGCGGGCACAATAAATCAGCCTAAATGTCCCTAATTTA ACCCAGCTCGTTATAATGTCATTAAACATGACATTAGCATTGTGGTTTTAGCACCCCCAT GGGTTTTGCTTAGGCACTCATGGGTAATAACCAAGATGGAGTCCCTTTGGCAAAACTTAG GCATGCACAGCTGTAGTACCCCAAGAAGAAAATGTTACTTCTCTCATCTGGGCAAAACCC ACAGAAGACTTCCCAGCTTCTGCCACATAAAAGACACAGAACACAGACGCCTTACTGGCA ACCTGCTTTCAAGACCCCTGTCTTTGCTGAGAGCTTTCCTTTTTCCCAATAAATTCTACT CTGCCCTACTCACTCTCAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC030253 unedited NAAGTTCAGATTTTGTAATACGACTCACTATAGGGGCAGGCCGCGNAATTCCCGGGGTAT CGTCGACCCACGCGTCCGGAGATAGGCCTGTGGGCCAGATTGCCATCCCCTATGGACCAG AAGCCAAGGATCTCTCTAGTGATGGTCAGAGGGCCCAAATGGCAGGGATACCCAGTGATG TCAGGAGGAATAGTACAGACAGAAGGTGCTAAGCAGACAATTCAACTGCCATGTTTTGCC ACCCCCTGTGAGCAGGGATTATGTGTTCAGGCCAGTATCTTGGGCATGGGGGAGCCTTTG GCCAGAAGAGGTATAAAGCTCAGAAGTTTTTCAGTCTGATAACTATTGATATAATTTCCA TAGTGTGAGGGAGCGGTATGCTCTACCCTTGTGTATTTAAGGCAGGACAGAGAAATTGAG GATGCCCCTGGGGCTAGATCGATGATATGACCAGAAATCAAAAAGGGAACGCATTATTTA TTGCTGTGTAACACTGTTAAGAGAGGAGGTAGTTAAGGGATGGATAGGCACATAGAGAGG GAAGGTCTCATGAGAAGGGATAGAAAGGAACTATGTTCACAAGAACAACGGCAAGACAGT GCCTATACTGCCTCTACAGTTAATAGGAAAAACGGAAGAAGTTACCCTTAAGCTAGGATG TTGCTCAGAAGTGACCATCCCAACTTTGGTGCGGGCACAATAAATCAGCCTAAATGTCCC TAATTTAACCCAGCTCGTTATAATGTCATTAAACATGACATTAGCATTGTGGTTTTAGCA CCCCCATGGGTTTTGCTTANGCACTCATGGGTAATAACCAAGATGGAGTCCCTTTGGCAA AACTANGCATGCACAGCTGTAGTACCCCAAGAAGAAAATGTTACTTCTCTCATCTGGGCA AACCCACAGAAGACTTCCCAGCTGCT
Restriction Sites	Please inquire
ACCN	BC030253
Insert Size	994 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC030253.1
RefSeq Size	994 bp
Locus ID	2947
Protein Pathways	Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450
Gene Summary	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

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