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Sortilin (SORT1) (NM_002959) Human Untagged Clone
CAT＃: SC118300
SORT1 (untagged)-Human sortilin 1 (SORT1), transcript variant 1
CNY 9,136.00
| Cited in 7 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Gp95; LDLCQ6; NT3; NTR3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002959 edited
GGCGGGCGCGCCGGGCGGCAGGTGTCGGCGTCGGCGGCATTCGGCGGCGATGGAGCGGCC CTGGGGAGCTGCGGACGGCCTCTCGCGCTGGCCCCATGGCCTCGGCCTCCTCCTCCTCCT GCAGCTGCTGCCGCCGTCGACCCTCAGCCAGGACCGGCTGGACGCGCCGCCGCCGCCCGC TGCGCCGCTGCCGCGCTGGTCTGGCCCCATCGGGGTGAGCTGGGGGCTGCGGGCGGCCGC AGCCGGGGGCGCGTTTCCCCGCGGCGGCCGTTGGCGTCGCAGCGCGCCGGGCGAGGACGA GGAGTGCGGCCGGGTCCGGGACTTCGTCGCCAAGCTGGCCAACAACACGCACCAGCATGT GTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGGGTCAT TCTAGTCTTGACTACCTTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCT ATATCGAAGTGAGGATTATGGGAAGAACTTTAAGGATATTACAGATCTCATCAATAACAC CTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGGTGTT AACAGCAGAGGTGTCTGGAGGAAGTCGTGGAGGAAGAATCTTCAGATCATCAGATTTTGC GAAGAATTTTGTGCAAACAGATCTCCCTTTTCATCCTCTCACTCAGATGATGTATAGCCC TCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCCAAGAA TTTTGGGGGAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGA CAACACCATCTTCTTTACAACCTATGCAAATGGCTCCTGCAAAGCTGACCTTGGGGCTCT GGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAAATCTA CTCATTTGGTCTTGGGGGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACCAC AAGAAGGATCCACGTTTCAACAGATCAAGGGGACACATGGAGCATGGCCCAGCTCCCCTC CGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTCATGCA TGTAGATGAACCTGGAGACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCAT TGTCTATTCCAAGTCTTTGGACCGACATCTCTACACTACCACAGGCGGAGAGACGGACTT TACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGATAATTC TATCCAGACCATGATCACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGA AAACAGTGAATGTGATGCTACAGCAAAAAACAAGAATGAGTGCAGCCTTCATATTCATGC TTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCGAATGC CGTAGGCATTGTCATTGCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGA TGTGTACATCTCAGATGATGGGGGTTACTCCTGGACAAAGATGCTGGAAGGACCCCACTA TTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGTCCTAT CAATGTGATTAAGTTCTCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAG GGACCCCATCTATTTCACTGGCCTAGCTTCAGAACCTGGAGCTAGGTCCATGAATATCAG CATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATTGATTT TAAAGATATCCTTGAAAGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTC CACAGACCCTGAAGATTATGAAGATGGCTGCATTTTGGGCTACAAAGAACAGTTTCTGCG GCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAGCCCTC CATCTGCCTCTGTTCCCTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAA TGACTCCAAGTGTGTGGAACAGCCAGAACTGAAGGGCCACGACCTGGAGTTTTGTCTGTA CGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAATGCCA GGGTGGGGTAAATCCAGTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTT TTTGAGTCCGGAAAAACAGAATTCCAAGTCAAATTCTGTTCCAATTATCCTGGCCATCGT GGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTCTGTGG GGGAAGGTTCCTGGTGCATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGT GGATGGTGTGGATGCTTTGGACACAGCCTCCCACACTAATAAAAGTGGTTATCATGATGA CTCAGATGAGGACCTCTTGGAATAGCTCTTCAGAGGAGCTGGACCCAGCATGGATGGTGG AACCACAGTACCTCTTACACTCCCTGTGGCTCCAACTTCAGGAAATAAATTTCCCATTGC GAGGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_002959 |
| Insert Size | 2700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_002959.4. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002959.4, NP_002950.3 |
| RefSeq Size | 7018 bp |
| RefSeq ORF | 2496 bp |
| Locus ID | 6272 |
| UniProt ID | Q99523 |
| Domains | BNR, VPS10 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome, Neurotrophin signaling pathway |
| Gene Summary | This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (7)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Aberrant Promoter Hypomethylation of Sortilin 1: A Moyamoya Disease Biomarker
,Sung, HY;Lee, JY;Park, AK;Moon, YJ;Jo, I;Park, EM;Wang, KC;Phi, JH;Ahn, JH;Kim, SK;,
J Stroke
,PubMed ID 30309230
[SORT1]
|
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Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis
,Arrant, AE;Onyilo, VC;Unger, DE;Roberson, ED;,
J. Neurosci.
,PubMed ID 29378861
[SORT1]
|
|
Production and Characterization of a Novel Monoclonal Antibody Against Human Sortilin
,Ghaemimanesh, F;Bayat, AA;Babaei, S;Ahmadian, G;Zarnani, AH;Behmanesh, M;Jeddi-Tehrani, M;Rabbani, H;,
Monoclon Antib Immunodiagn Immunother Dec2015
,PubMed ID 26683178
[SORT1]
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SORT1 Mutation Resulting in Sortilin Deficiency and p75NTR Upregulation in a Family With Essential Tremor
,Sánchez, E;Bergareche, A;Krebs, CE;Gorostidi, A;Makarov, V;Ruiz-Martinez, J;Chorny, A;Lopez de Munain, A;Marti-Masso, JF;Paisán-Ruiz, C;,
ASN Neuro
,PubMed ID 26297037
[SORT1]
|
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Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other
,Butkinaree, C;Canuel, M;Essalmani, R;Poirier, S;Benjannet, S;Asselin, MC;Roubtsova, A;Hamelin, J;Marcinkiewicz, J;Chamberland, A;Guillemot, J;Mayer, G;Sisodia, SS;Jacob, Y;Prat, A;Seidah, NG;,
J. Biol. Chem.
,PubMed ID 26085104
[SORT1]
|
|
Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency
,Lee, WC;Almeida, S;Prudencio, M;Caulfield, TR;Zhang, YJ;Tay, WM;Bauer, PO;Chew, J;Sasaguri, H;Jansen-West, KR;Gendron, TF;Stetler, CT;Finch, N;Mackenzie, IR;Rademakers, R;Gao, FB;Petrucelli, L;,
Hum Mol Genet. 2013 Nov 7.
,PubMed ID 24163244
[SORT1]
|
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Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor
,Mercedes Prudencio, Karen R. Jansen-West, Wing C. Lee, Tania F. Gendron, Yong-Jie Zhang, Ya-Fei Xu, Jennifer Gass, Cristiana Stuani, Caroline Stetler, Rosa Rademakers, Dennis W. Dickson, Emanuele Buratti, and Leonard Petrucelli,
PNAS, Dec 2012; 109: 21510 - 21515.
[SORT1]
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Documents
| Product Manuals |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203429 | SORT1 (Myc-DDK-tagged)-Human sortilin 1 (SORT1), transcript variant 1 |
CNY 3,990.00 |
|
| RC203429L1 | Lenti-ORF clone of SORT1 (Myc-DDK-tagged)-Human sortilin 1 (SORT1), transcript variant 1 |
CNY 5,890.00 |
|
| RC203429L2 | Lenti-ORF clone of SORT1 (mGFP-tagged)-Human sortilin 1 (SORT1), transcript variant 1 |
CNY 5,890.00 |
|
| RC203429L3 | Lenti-ORF clone of SORT1 (Myc-DDK-tagged)-Human sortilin 1 (SORT1), transcript variant 1 |
CNY 5,890.00 |
|
| RC203429L4 | Lenti-ORF clone of SORT1 (mGFP-tagged)-Human sortilin 1 (SORT1), transcript variant 1 |
CNY 5,890.00 |
|
| RG203429 | SORT1 (tGFP-tagged) - Human sortilin 1 (SORT1), transcript variant 1 |
CNY 4,370.00 |
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