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Angiotensin II Type 1 Receptor (AGTR1) (NM_004835) Human Untagged Clone
CAT＃: SC117130
AGTR1 (untagged)-Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3
CNY 5,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_004835, the custom clone sequence may differ by one or more nucleotides
ATGAAGAAAATGAATCACAAGTCAACTGACAGTCCAAAGGCTCCACAGCTCAGAGGAGGTGTATTTGATA TAGTGTTTGCAACAAATTCGACCCAGGTGATCAAAATGATTCTCAACTCTTCTACTGAAGATGGTATTAA AAGAATCCAAGATGATTGTCCCAAAGCTGGAAGGCATAATTACATATTTGTCATGATTCCTACTTTATAC AGTATCATCTTTGTGGTGGGAATATTTGGAAACAGCTTGGTGGTGATAGTCATTTACTTTTATATGAAGC TGAAGACTGTGGCCAGTGTTTTTCTTTTGAATTTAGCACTGGCTGACTTATGCTTTTTACTGACTTTGCC ACTATGGGCTGTCTACACAGCTATGGAATACCGCTGGCCCTTTGGCAATTACCTATGTAAGATTGCTTCA GCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTTTCTACTCACGTGTCTCAGCATTGATCGATACCTGG CTATTGTTCACCCAATGAAGTCCCGCCTTCGACGCACAATGCTTGTAGCCAAAGTCACCTGCATCATCAT TTGGCTGCTGGCAGGCTTGGCCAGTTTGCCAGCTATAATCCATCGAAATGTATTTTTCATTGAGAACACC AATATTACAGTTTGTGCTTTCCATTATGAGTCCCAAAATTCAACCCTCCCGATAGGGCTGGGCCTGACCA AAAATATACTGGGTTTCCTGTTTCCTTTTCTGATCATTCTTACAAGTTATACTCTTATTTGGAAGGCCCT AAAGAAGGCTTATGAAATTCAGAAGAACAAACCAAGAAATGATGATATTTTTAAGATAATTATGGCAATT GTGCTTTTCTTTTTCTTTTCCTGGATTCCCCACCAAATATTCACTTTTCTGGATGTATTGATTCAACTAG GCATCATACGTGACTGTAGAATTGCAGATATTGTGGACACGGCCATGCCTATCACCATTTGTATAGCTTA TTTTAACAATTGCCTGAATCCTCTTTTTTATGGCTTTCTGGGGAAAAAATTTAAAAGATATTTTCTCCAG CTTCTAAAATATATTCCCCCAAAAGCCAAATCCCACTCAAACCTTTCAACAAAAATGAGCACGCTTTCCT ACCGCCCCTCAGATAATGTAAGCTCATCCACCAAGAAGCCTGCACCATGTTTTGAGGTTGAGTGA >OriGene 5' read for NM_004835 unedited
GGTTCANCATTTGTAATACGACTCACTATTAGGGCGGCCGCGATTCGGCACCAGGCCAGG ACCCCAGGCAGCAGCGAGTGACAGGACGTCTGGACCGGCGCGCCGCTAGCAGCTCTGCCG GGCCGCGGCGGTGATCGATGGGGAGCGGCTGGAGCGGACCCAGCGAGTGAGGGCGCACAG CCGGGACGCCGAGGCGGCGGGCGGGAGACCCGCACCAGCGCAGCCGGCCCTCGGCGGGAC GTGACGCAGCGCCCGGGGCGCGGGTGTATTTGATATAGTGTTTGCAACAAATTCGACCCA GGTGATCAAAATGATTCTCAACTCTTCTACTGAAGATGGTATTAAAAGAATCCAAGATGA TTGTCCCAAAGCTGGAAGGCATAATTACATATTTGTCATGATTCCTACTTTATACAGTAT CATCTTTGTGGTGGGAATATTTGGAAACAGCTTGGTGGTGATAGTCATTTACTTTTATAT GAAGCTGAAGACTGTGGCCAGTGTTTTTCTTTTGAATTTAGCACTGGCTGACTTATGCTT TTTACTGACTTTGCCACTATGGGCTGTCTACACAGCTATGGAATACCGCTGGCCCTTTGG CAATTACCTATGTAAGATTGCTTCAGCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTT TCTACTCACGTGTCTCAGCATTGATCGATACCTGGCTATTGTTCACCCAATGAAGTCCCG CCTTCGACGCACAATGCTTGTAGCCAAAGTCACCTGCATCATCATTTGGCTGCTGGCAGG CTTGGCCAGTTTGCCAGCTATTATCCATCCGAATGTATTTTTTCATTGAGAAACACCATA TTACAGTTTTGTGGCTTTCCATTATTGAGTCCCAAATTTCACCCTTCCGATAGGGCTGGG CCTGACCAAAATATACTGGGTTTC >OriGene 3' read for NM_004835 unedited
GGATTACTTTTTTTTTTAAGTAAATTAACTTTGGCCGAATTTAATCAATTAACAGCAGTT TAGAGATATAGATATACATATATATATATGTGTAGAATATATACTTTTTTTAAACAGGAA GGCATACTTTATGATATATAATCTTTTTACCACAAACTATATACACTTCTCAGATATTAA ATCAAACTAATATACTAGGAAGACACTACTACTTGGGACCAGTGCAGCACCTTTACAAGT AGTTTAACTTTTATATGTGACTTTAGTAACACCATTATACAAATAAGCCATCTTACGGGC ATTGTTTTGGCAGTGTAAACCTATAAGACACAGGTTGAATTTCACAAAAAGATCTGCAAC TTGACGACTACTGCTTAGCATATCTTTGTACAAAATGTGCAGTACCAGGTGCAAGTGTAG CACAGTTGCTAATAGCTGAAAACCGGCACGAAAACTTTACTGCCCTTTGGAAACTGGACA GAACAATCTGGAACTCTCATCTCCTGTTGCTCCTCTAACGATTTAATATATTCTAAATAC CTTTATGTGGAAATAAAAAATAACAGGACAAAAGCAGGCTAGGGAGATTGCATTTCTGTC AGTAAAATTTCTCAAATCAACACATTCATCGAGTTTCTGACATTGTTCTTCGAGCAGCCG TCATCTGTCTAATGCAAAATGTGGCTNTGCTNTGTCTTGTTGCNAAGGAAAGAAAAGCTT TGTTCAGAGCTTAGAAAAGTCGGGTTCAGTCACATAATGCATTTTCTNCTTCATTCTGAA AGTAGCTATGCTCATTTGGTANTGAGTGCTGCAGAGGATGTTCTCTTGCTCCTTCTTCAC AAAATACTTATGGACAGGNTTCGAACATGTACTCACCTCAAACATGGTGCAGGCTTNCTG GTGGATGAGCTAATTATCTGAGGGGCGTGGAAAGCGGCTCAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004835 |
| Insert Size | 2260 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_004835.2, NP_004826.2 |
| RefSeq Size | 2342 bp |
| RefSeq ORF | 1080 bp |
| Locus ID | 185 |
| UniProt ID | P30556 |
| Domains | 7tm_1 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction, Renin-angiotensin system, Vascular smooth muscle contraction |
| Gene Summary | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020] Transcript Variant: This variant (3), also known as hAT1R-B (PubMed ID:11158334) or hAT1R-C (PubMed ID:16504375), has an alternate exon in the 5' region, which contains an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209773 | AGTR1 (Myc-DDK-tagged)-Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3 |
CNY 5,488.00 |
|
| RC209773L1 | Lenti ORF clone of Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC209773L2 | Lenti ORF clone of Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3, mGFP tagged |
CNY 5,890.00 |
|
| RC209773L3 | Lenti ORF clone of Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209773L4 | Lenti ORF clone of Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3, mGFP tagged |
CNY 5,890.00 |
|
| RG209773 | AGTR1 (tGFP-tagged) - Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3 |
CNY 7,088.00 |
|
| SC322091 | AGTR1 (untagged)-Human angiotensin II receptor, type 1 (AGTR1), transcript variant 3 |
CNY 5,488.00 |
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