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Profilin 1 (PFN1) (NM_005022) Human Untagged Clone
CAT＃: SC117015
PFN1 (untagged)-Human profilin 1 (PFN1)
CNY 1,200.00
CNY 2,950.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ALS18 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC117015 sequence for NM_005022 edited (data generated by NextGen Sequencing)
ATGGCCGGGTGGAACGCCTACATCGACAACCTCATGGCGGACGGGACCTGTCAGGACGCG GCCATCGTGGGCTACAAGGACTCGCCCTCCGTCTGGGCCGCCGTCCCCGGGAAAACGTTC GTCAACATCACGCCAGCTGAGGTGGGTGTCCTGGTTGGCAAAGACCGGTCAAGTTTTTAC GTGAATGGGCTGACACTTGGGGGCCAGAAATGTTCGGTGATCCGGGACTCACTGCTGCAG GATGGGGAATTTAGCATGGATCTTCGTACCAAGAGCACCGGTGGGGCCCCCACCTTCAAT GTCACTGTCACCAAGACTGACAAGACGCTAGTCCTGCTGATGGGCAAAGAAGGTGTCCAC GGTGGTTTGATCAACAAGAAATGTTATGAAATGGCCTCCCACCTTCGGCGTTCCCAGTAC TGA Clone variation with respect to NM_005022.2 >OriGene 5' read for NM_005022 unedited
GCACGAGGGCGGTCCGGACGGCAGCGCGTGCCCCGAGCTCTCCGCCTCCCCCCGCCCGCC AGCCGAGGCAGCTCGAGCCCAGTCCGCGGCCCCAGCAGCAGCGCCGAGAGCAGCCCCAGT AGCAGCGCCATGGCCGGGTGGAACGCCTACATCGACAACCTCATGGCGGACGGGACCTGT CAGGACGCGGCCATCGTGGGCTACAAGGACTCGCCCTCCGTCTGGGCCGCCGTCCCCGGG AAAACGTTCGTCAACATCACGCCAGCTGAGGTGGGTGTCCTGGTTGGCAAAGACCGGTCA AGTTTTTACGTGAATGGGCTGACACTTGGGGGCCAGAAATGTTCGGTGATCCGGGACTCA CTGCTGCAGGATGGGGAATTTAGCATGGATCTTCGTACCAAGAGCACCGGTGGGGCCCCC ACCTTCAATGTCACTGTCACCAAGACTGACAAGACGCTAGTCCTGCTGATGGGCAAAGAA GGTGTCCACGGTGGTTTGATCAACAAGAAATGTTATGAAATGGCCTCCCACCTTCGGCGT TCCCAGTACTGACCTCGTCTGTCCCTTCCCCTTCACCGCTCCCCACAGCTTTGCACCCCT TTCCTCCCCATACACACACAAACCAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005022 |
| Insert Size | 950 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_005022.2, NP_005013.1 |
| RefSeq Size | 847 bp |
| RefSeq ORF | 423 bp |
| Locus ID | 5216 |
| UniProt ID | P07737 |
| Domains | PROF |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Regulation of actin cytoskeleton |
| Gene Summary | This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1a accumulation
,Fan, Y;Potdar, AA;Gong, Y;Eswarappa, SM;Donnola, S;Lathia, JD;Hambardzumyan, D;Rich, JN;Fox, PL;,
Nat. Cell Biol. . April 2014
,PubMed ID 24747440
[PFN1]
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Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
,Yi Fan, Abul Arif, Yanqing Gong, Jie Jia, Sandeepa M. Eswarappa, Belinda Willard, Arie Horowitz, Linda M. Graham, Marc S. Penn & Paul L. Fox,
Nature Cell Biology 14, 1046-1056 doi:10.1038/ncb2580
[PFN1]
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Documents
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Resources
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| RC202338L3 | Lenti ORF clone of Human profilin 1 (PFN1), Myc-DDK-tagged |
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| RC202338L4 | Lenti ORF clone of Human profilin 1 (PFN1), mGFP tagged |
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| RG202338 | PFN1 (tGFP-tagged) - Human profilin 1 (PFN1) |
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