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FMO3 (NM_006894) Human Untagged Clone
CAT＃: SC115806
FMO3 (untagged)-Human flavin containing monooxygenase 3 (FMO3), transcript variant 1
CNY 2,950.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | dJ127D3.1; FMOII; TMAU |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC115806 sequence for NM_006894 edited (data generated by NextGen Sequencing)
ATGGGGAAGAAAGTGGCCATCATTGGAGCTGGTGTGAGTGGCTTGGCCTCCATCAGGAGC TGTCTGGAAGAGGGGCTGGAGCCCACCTGCTTTGAGAAGAGCAATGACATTGGGGGCCTG TGGAAATTTTCAGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCC AACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAAC TTTATGCACAACAGCAAGATCCAGGAATATATCATTGCATTTGCCAAAGAAAAGAACCTC CTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCA ACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTT GATGCTGTAATGGTTTGTTCCGGACATCATGTGTATCCCAACCTACCAAAAGAGTCCTTT CCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGT GTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCC ACAGAACTCAGCCGCACAGCAGAACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTG ATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGA ACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACATGAAGCAGATG AATGCAAGATTCAAGCATGAAAACTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAA GAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTCCGTAAAG CCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAG GGCATTGACTGTGTAATCTTTGCAACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAG TCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTA CTTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCC ACAGTTGACCTCCAGTCCCGCTGGGCAGCACAAGTAATAAAGGGAACTTGTACTTTGCCT TCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAAATGGTTT GGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTC ATTGGGGCAAAGCCCAACATCCCATGGCTGTTTCTCACAGATCCCAAATTGGCCATGGAA GTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCAGTGGCCA GGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGA GTGGTCGGGAGACTTCAGAAGCCTTGCTTTTTTTTCCATTGGCTGAAGCTCTTTGCAATT CCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAA Clone variation with respect to NM_006894.5 769 g=>a;1530 c=>t >OriGene 5' read for NM_006894 unedited
GCACCAGAAGGTTGGACAGGACGTAGACACACAGAAGAAAAGAAGACAAAGAACGGGTAG GAAAATTAAAAAGGTTACCATGGNGGAAGAAAGTGGCCATCATTGGAGCTGGTGTGAGTG GCTTGGCCTCCATCAGGAGCTGTCTGGAAGAGGGGCTGGAGCCCACCTGCTTTGAGAAGA GCAATGACATTGGGGGCCTGTGGAAATTTTCAGACCATGCAGAGGAGGGCAGGGCTAGCA TTTACAAATCAGTCTTTTCCAACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCAT TTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCAGGAATATATCATTGCAT TTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAA ATAAACATCCTGATTTTGCAACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTA AAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGGACATCATGTGTATCCCA ACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCA GGGACTATAAAGAACCAGGTGTATTCAATGGAAAGCGTGTCCTGGNTGGTTGGCCTGGGG AAATTCGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGAAACAGGTCATGATCAG TTNCCAGAAGTGGCTCCTGGGT >OriGene 3' read for NM_006894 unedited
NNNNTTTACTTGNNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTATAATTATATCTGCTTAATTTGCTCTTTATTTAAATTTAAAATACATCTTT CATACATTGTTTAAAAGGAAAAAGGAATCATGTCAAAATGTTTCAGGAAATGATTTAAGT TAAATATAAAGAACATAGTTCTGATTTTGAAGTGTTAGTGGAACTCAAACAGAAATGATT AGTGCTCTCTTAAGATCATGACATGATTCTTAAAGTGGCTATTTCAAAGCCTAAAAATAA CACTGTATTACTGACTAATGTCTACAGAGTACTGCAAAAGATGCTGAATAGAAAAGCAGG TGGTGTGAAAATTTTAATTTTTAAATAGCAAAGCCCCTGTCTGGGTATTGTCAGTAACTT TCAAAAATCCTAGAGAAAATGATGATTAGGTCAACACAAGGAAAACAGCGATTAACAGAA TAGGAATTGCAAAGAGCTTCAGCCAATGGAAAAAAAAGCAAGGCTTCTGAAGTCTCCCGA CCACTCGTGTCTGCATGGGTTTCAACGACCGGTCCCACTGGGTCAGTATGGCATTTCTGG CTCCTGGCCACTGCCCTGGGCCCACCAGCCTAAACTGGTAGGGACTACAAGGGCCAAAAT AAACTTCCATGGNCCAATTTGGGATCTGTGAGAAACAGCCATGGGATGTTGGGCTTTGCC CCAATGAAGGAGGGAGAGTTCATCCATATAAACAATGTAATCTGTCTGTATGGTCTCGCT TTTGCCAAACATTTGCNGCTTTTCTNCTTNTTCTCATTAATATCATTNCATCATGTCTCC ATAGAAGGGCAAGTACAGTTCCTTTTATTACTGTGCTGCCCAGCGGACTGGAGGGTCACT GTGGAATGCAGCCCCAGGGACTGGACAAGCCATACTGCTATGGTGACTTTC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006894 |
| Insert Size | 2140 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006894.4, NP_008825.4 |
| RefSeq Size | 2053 bp |
| RefSeq ORF | 1599 bp |
| Locus ID | 2328 |
| UniProt ID | P31513 |
| Domains | FMO-like |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Drug metabolism - cytochrome P450 |
| Gene Summary | Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016] Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 both encode the same isoform (a). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206506 | FMO3 (Myc-DDK-tagged)-Human flavin containing monooxygenase 3 (FMO3), transcript variant 1 |
CNY 3,960.00 |
|
| RC206506L1 | Lenti ORF clone of Human flavin containing monooxygenase 3 (FMO3), transcript variant 1, Myc-DDK-tagged |
CNY 6,360.00 |
|
| RC206506L2 | Lenti ORF clone of Human flavin containing monooxygenase 3 (FMO3), transcript variant 1, mGFP tagged |
CNY 6,460.00 |
|
| RC206506L3 | Lenti ORF clone of Human flavin containing monooxygenase 3 (FMO3), transcript variant 1, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC206506L4 | Lenti ORF clone of Human flavin containing monooxygenase 3 (FMO3), transcript variant 1, mGFP tagged |
CNY 6,460.00 |
|
| RG206506 | FMO3 (tGFP-tagged) - Human flavin containing monooxygenase 3 (FMO3), transcript variant 1 |
CNY 5,040.00 |
