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FANCL (NM_018062) Human Untagged Clone
CAT＃: SC113748
FANCL (untagged)-Human Fanconi anemia, complementation group L (FANCL), transcript variant 2
CNY 5,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FAAP43; PHF9; POG |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC113748 sequence for NM_018062 edited (data generated by NextGen Sequencing)
ATGGCGGTGACGGAAGCGAGCCTGTTGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGG TCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAGGGAAGAGACTTCCACCTTAGGATA GTGTTGCCTGAAGATTTACAACTGAAGAATGCAAGATTATTATGTAGTTGGCAGCTGAGA ACAATACTTAGTGGATACCATCGAATAGTACAACAGAGAATGCAGCACTCTCCTGATCTA ATGAGCTTTATGATGGAGTTGAAGATGCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAG CTGTATGCACTACCTCCTCCTCCCCAGTTCTACTCAAGCCTTATTGAAGAGATAGGAACT CTTGGTTGGGATAAACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCA GAAGATGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAGTATCCTGCA GAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCCTCCTGGACACCTCAG AGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTC TGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCA CGGAGTGCAACAGCACGCAGAATTGCATTAGGTAATAATGTTTCCATAAATATAGAGGTA GACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTTTTGGAGCTGACCATGTGGTA AAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTGGGATCCAGAAAATAGTGTG TTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAA TCTGATTTTACTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCT GATCAAGTGTGTGATAATTCCCAGTGTGGACAACCTTTCCATCAAATATGCTTATATGAG TGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCA TATTGTAGTAAGCCAATTACCTTAAAAATGTCTGGAAGGAAACACTGA Clone variation with respect to NM_018062.3 760 c=>t;981 t=>c >OriGene 5' read for NM_018062 unedited
NNGGGTGCACATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGCAGGTC TAGAGCTTTTCTGTGTTTCTCCGGACTTCGAGCCATGGCGGTGACGGAAGCGAGCCTGTT GCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGGTCGAAAACCGTGTATGAGGGATTCAT CTCGGCTCAGGGAAGAGACTTCCACCTTAGGATAGTGTTGCCTGAAGATTTACAACTGAA GAATGCAAGATTATTATGTAGTTGGCAGCTGAGAACAATACTTAGTGGATACCATCGAAT AGTACAACAGAGAATGCAGCACTCTCCTGATCTAATGAGCTTTATGATGGAGTTGAAGAT GCTTTTGGAAGTTGCCTTAAAGAATAGACAAGAGCTGTATGCACTACCTCCTCCTCCCCA GTTCTACTCAAGCCTTATTGAAGAGATAGGAACTCTTGGTTGGGATAAACTTGTGTATGC GGATACCTGCTTCAGTACCATCAAGTTAAAAGCAGAAGATGCTTCTGGTAGAGAGCATTT AATCACTCTCAAGTTGAAGGCAAAGTATCCTGCAGAATCACCAGATTATTTTGTGGATTT TCCTGTTCCATTTTGTGCCTCCTGGACACCTCAGAGCTCCTTAATAAGCATTTATAGTCA GTTTTTGGCAGCAATAGAATCACTAAAGGCATTCTGGGATGTTATGGATGAAATCGATGA GAAGACCTGNGTACTTGAGCCAGANAAACCTCCACGGAGTGCAACAGCACGCAGAATTGC ATTAGGTAATAATGTTTCCATAAATATAGAGGTAGACCCCAGGCATNCTACTATGCTTNC TGAGTGCTTCTTTTTTGGAGCTGACCATGTGGTAAAACCCCTGNGAATTAAGCTG >OriGene 3' read for NM_018062 unedited
ACGCGGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTGATCTTGTATAACATTT TATTTAGCATTCTTACACACTACACAAAATAAATACTTGGATAACTCACGTCTAACAAAC TAAACTATACTATGTATTCTTTCTCCATAGGGAAAGCACAAGGAGAAGACAGAAATATCA AGAGTCTCAAGAACCTTTGAATGAAGTAAACAGTTTCCCACAAAAAATCAGCTATACACA ATTCCCAAACTCATTTTATGAGCCTCATCAAGATTTTACCAGTCCAGATATATTCAAGAA GTCAAGATCTCCATCTTGGTATAAATACACTTCCACAGTCAGCACGGGGATCACAGACTT AGAAAGTTCAACTGGACTTTGGCCTACAATTTCCCAGTTTACTCTTAGTGAAGAGACAAA CGCAGATGTTTATTATTATCGCATCATCATACCTGTCCTTTTGATGTTAGTATTTCTTGC TTTATTTTTTCTCTGAAGATGATACCAAAATTCCTTTTGATAATTTTTTAAGTTTCCAGC TCTTCACCGAAATGTTGTATTCTTATTTCAGTGTTTCCTTCCAGACATTTTTAAGGTAAT TGGCTTACTACAATATGGACATTCACCAAATATGATGTTAAAACTCTGTCTACTAGTTAG TAGTCCTCTCAGCCACTCATATAAGCATATCTGATGGAAAGGCTGTCCACACTGGGAATT ATCACACACTTGATCAGGAATGGTACCGTCAAGTTGATAAGCCTAACAAATTCCACACTC CTATAAAATCAGATTTTCCAGATAGACGAGCTGGAAAATAATTTCTAAACATCTTCGAAT TTGCACACACTTTTTTTGAATCCACAAATGATGTGCTGCTCACTAATCCACAGGTTTACA CATGGCACCTCCAAAGAACCCCAGGACCTGTAGAGGCCGGGTCTACTT |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_018062 |
| Insert Size | 1730 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_018062.2, NP_060532.2 |
| RefSeq Size | 1750 bp |
| RefSeq ORF | 1128 bp |
| Locus ID | 55120 |
| UniProt ID | Q9NW38 |
| Protein Pathways | Ubiquitin mediated proteolysis |
| Gene Summary | This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2018] Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208718 | FANCL (Myc-DDK-tagged)-Human Fanconi anemia, complementation group L (FANCL), transcript variant 2 |
CNY 5,488.00 |
|
| RC208718L1 | Lenti ORF clone of Human Fanconi anemia, complementation group L (FANCL), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC208718L2 | Lenti ORF clone of Human Fanconi anemia, complementation group L (FANCL), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC208718L3 | Lenti ORF clone of Human Fanconi anemia, complementation group L (FANCL), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208718L4 | Lenti ORF clone of Human Fanconi anemia, complementation group L (FANCL), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG208718 | FANCL (tGFP-tagged) - Human Fanconi anemia, complementation group L (FANCL), transcript variant 2 |
CNY 7,088.00 |
