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SHP2 (PTPN11) (NM_002834) Human Untagged Clone
CAT＃: SC112718
PTPN11 (untagged)-Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11)
CNY 4,424.00
CNY 9,600.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC112718 sequence for NM_002834 edited (data generated by NextGen Sequencing)
ATGACATCGCGGAGATGGTTTCACCCAAATATCACTGGTGTGGAGGCAGAAAACCTACTG TTGACAAGAGGAGTTGATGGCAGTTTTTTGGCAAGGCCTAGTAAAAGTAACCCTGGAGAC TTCACACTTTCCGTTAGAAGAAATGGAGCTGTCACCCACATCAAGATTCAGAACACTGGT GATTACTATGACCTGTATGGAGGGGAGAAATTTGCCACTTTGGCTGAGTTGGTCCAGTAT TACATGGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTCATTGAGCTTAAATAT CCTCTGAACTGTGCAGATCCTACCTCTGAAAGGTGGTTTCATGGACATCTCTCTGGGAAA GAAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGTTTTCTTGTACGAGAGAGC CAGAGCCACCCTGGAGATTTTGTTCTTTCTGTGCGCACTGGTGATGACAAAGGGGAGAGC AATGACGGCAAGTCTAAAGTGACCCATGTTATGATTCGCTGTCAGGAACTGAAATACGAC GTTGGTGGAGGAGAACGGTTTGATTCTTTGACAGATCTTGTGGAACATTATAAGAAGAAT CCTATGGTGGAAACATTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACACGACTCGT ATAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACA GATAAAGTCAAACAAGGCTTTTGGGAAGAATTTGAGACACTACAACAACAGGAGTGCAAA CTTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA AACATCCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGGTGATCCCAATGAGCCT GTTTCAGATTACATCAATGCAAATATCATCATGCCTGAATTTGAAACCAAGTGCAACAAT TCAAAGCCCAAAAAGAGTTACATTGCCACACAAGGCTGCCTGCAAAACACGGTGAATGAC TTTTGGCGGATGGTGTTCCAAGAAAACTCCCGAGTGATTGTCATGACAACGAAAGAAGTG GAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTCTAAAAGAATAT GGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCCGCTCATGACTATACGCTAAGAGAA CTTAAACTTTCAAAGGTTGGACAAGGGAATACGGAGAGAACGGTCTGGCAATACCACTTT CGGACCTGGCCGGACCACGGCGTGCCCAGCGACCCTGGGGGCGTGCTGGACTTCCTGGAG GAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAGGGCCGGTCGTGGTGCACTGCAGT GCTGGAATTGGCCGGACAGGGACGTTCATTGTGATTGATATTCTTATTGACATCATCAGA GAGAAAGGTGTTGACTGCGATATTGACGTTCCCAAAACCATCCAGATGGTGCGGTCTCAG AGGTCAGGGATGGTCCAGACAGAAGCACAGTACCGATTTATCTATATGGCGGTCCAGCAT TATATTGAAACACTACAGCGCAGGATTGAAGAAGAGCAGAAAAGCAAGAGGAAAGGGCAC GAATATACAAATATTAAGTATTCTCTAGCGGACCAGACGAGTGGAGATCAGAGCCCTCTC CCGCCTTGTACTCCAACGCCACCCTGTGCAGAAATGAGAGAAGACAGTGCTAGAGTCTAT GAAAACGTGGGCCTGATGCAACAGCAGAAAAGTTTCAGATGA Clone variation with respect to NM_002834.3 >OriGene 5' read for NM_002834 unedited
AAACGCAATTCGCACGAGGAGCTGCACATTCTCGGGGTATCCCCAGGCCTGGTAGGGGGT CTGTGCGCGGCCGGATGGCTCTGCCCCGCGTCCGGTCCCGAGCGGGCCTCCCTCGGGCCA GCCCGATGTGACCGAGCCCAGCGGAGCCTGAGCAAGGAGCGGGTCCGTCGCGGAGCCTTA GTGCGTTAGGAACATGACATCGCGTATATGGGGGCACCCAAATATCACTGGTGCGGAGGC AGAAAACCTACTGTTGACGAGAGGAGTTGATGGCACTTTTTTGGCAAGGCCTAATAAAAG TAACCCTGGATACTTCACACTTTCCGTTAGAAGAAATGGAGCTGTCACCCACATGAAGAT TCATAACACTGGTGATTACTATGACCTGTATGGAGGGGAGAAATTTGCCACTTTGGCTGA ATTGGTCCAGTATTACATGGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTCAT TGATCTTAAATATCCTCTGAACTGTGCAGATCCTACCTCTGAAAGGTGGTTTCATGGACA TCTCTCTGGGAGAGAAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGGTTTCT TGTACTAGAGAGCCATACCCTCCCTGGAGATTTTGGTCTTTCTGTGCGCACTGGTGATCA CATACGGGAGAGCAATGACGGCAAGTCTAAAGTGACCCATGTTATGATTCGCTGACAGGA ACTGAAATACCACGTTGGTGGAGGAGAACGTTTGATTCTTTGACAGATCTTGTGGAACAT TATAAGAAAGATCCTATGGTGAAAACATTGGGTACAGTCCTACAACTCAAGCAGCCCCCT AACACGACTGGTATAAATGCTGCTGAAATGGACA >OriGene 3' read for NM_002834 unedited
NNNNAAAATCACTTGNNACCGCGGCCGCTTTCTANATCGAGTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTATAAAAAAAGGTTTTATTCCTAATTTTTAGTTCCCATA CAGTTTACAAATACACTTTTACTCTGATAATACAGCTTTGCAACTAGCAAAGCAGTTGCG CTAACACCCATAAATATAGGTGGGGAGACAATTAACATCCACTAATGTTTCTCTACATAA ACTATTCTTTTAATGGCATTTTTTTAAAAACAGTTGCAAATAGACTACATAATATACGTG GGCAAAAAGGCAATTAAGTGAATCTCTTGAAACACTAAATGTTTAATAAACAGCATATTA TCAACATTTACATGATTCACATCAAAATGATGACCTCCTAAAACGTATTCCTTTTAAAGG ATAGATTTATCAATAAAATATTACATATCTTTTAATACTCTGGTACAATACTTCATATAC TGCAGGAAAATTAATTGTAGGTCTAGTCATCAGCTTAATCAGGGATCCTTTTCCCATTAG CTTTTATTAATAAAAGAATCACAATTAGGTCATAAATAAACAGGCAAATTATTAATTACC TTATTTGAGGCTTAGGATGAAAACTTGTCAAAATTAGTTTGATATACCGCAAAGTTATAC AACCCACTAAAACCAACTGTTCAATAGTTTTTGCCTTGTGTGAACTGCCCATAGTGAAAA AGGAACAAATTTTTAGTGTTGAAAGATACCATAAACTATTTTTTGGAACTTTTCAAGGAG AAGAAGGGAAAAAGATTTCCACAAAATTTTAGGCAAATCCAGATCCTAACAAAAGCCTTC CGGACATCAGGGGGGCCATGGTGCTTGTTATGTGGGAAAATTGGTCCCCCCACAACATA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002834 |
| Insert Size | 6600 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002834.3, NP_002825.3 |
| RefSeq Size | 6300 bp |
| RefSeq ORF | 1782 bp |
| Locus ID | 5781 |
| UniProt ID | Q06124 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma |
| Gene Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016] Transcript Variant: This variant (1) encodes isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220029 | PTPN11 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11) |
CNY 4,416.00 |
|
| RC220029L1 | Lenti-ORF clone of PTPN11 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11) |
CNY 6,816.00 |
|
| RC220029L2 | Lenti-ORF clone of PTPN11 (mGFP-tagged)-Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11) |
CNY 7,130.00 |
|
| RC220029L3 | Lenti-ORF clone of PTPN11 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11) |
CNY 6,816.00 |
|
| RC220029L4 | Lenti-ORF clone of PTPN11 (mGFP-tagged)-Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11) |
CNY 6,816.00 |
|
| RG220029 | PTPN11 (tGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 11 (PTPN11) |
CNY 5,700.00 |
