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PAR4 (PAWR) (NM_002583) Human Untagged Clone
CAT＃: SC110969
PAWR (untagged)-Human PRKC, apoptosis, WT1, regulator (PAWR)
CNY 2,950.00
| Cited in 5 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Par-4; PAR4 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110969 sequence for NM_002583 edited (data generated by NextGen Sequencing)
ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTG GAGGAGTGGAAGGCGAAACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCC CCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCA CCTGCCGTCCCCGGTCCCGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGG GCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCG GGCCCCAGTGCCAGGAAAGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGG CGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGTGCTTAGATGAGTACGAAGATGAT GAAGCAGGGCAGAAAGAGCGGAAACGAGAAGATGCAATTACACAACAGAACACTATACAG AATGAAGCTGTAAACTTACTAGATCCAGGCAGTTCCTATCTGCTACAGGAGCCACCTAGA ACAGTTTCAGGCAGATATAAAAGCACAACCAGTGTCTCTGAAGAAGATGTCTCAAGTAGA TATTCTCGAACAGATAGAAGTGGGTTCCCTAGATATAACAGGGATGCAAATGTTTCAGGT ACTCTGGTTTCAAGTAGCACACTGGAAAAGAAAATTGAAGATCTTGAAAAGGAAGTAGTA AGAGAAAGACAAGAAAACCTAAGACTTGTGAGACTGATGCAAGATAAAGAGGAAATGATT GGAAAACTCAAAGAAGAAATTGATTTATTAAATAGAGACCTAGATGACATAGAAGATGAA AATGAACAGCTAAAGCAGGAAAATAAAACTCTTTTGAAAGTTGTGGGTCAGCTGACCAGG TAG Clone variation with respect to NM_002583.2 597 t=>a >OriGene 5' read for NM_002583 unedited
TCCCGCCCCGTTGCCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA GCTTATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT TCGGCACGAGGGAGAAACTTTGCAGGGTGGGGACCCGGCGGCTGCTGGCCGGTAGTGACT GGTGGGCGCGCTCGAGGACTCCAAGGGGCGCAGCCCGGGGGCAGACCCTTGGGTCGGGCG GGGATCTTACGCTTCCCTTACCCGCCCCCTTTTGTCTTTCACCTCAGCCCCGCCGGCTGC TGTGGGAGCGGCGGCCGTCCCTCTCCTGGAGGTCGTCTCCTGGCATCCTCGGGGCCGCAG GAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCG GCCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCA CCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATGCGCGCCAAGCAGAACC CCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGG NGGCTCTGGGCACCCCGGCGGCCGNCGCTGCCAACGAGCTCAACACAACCTCCCGGGCGG CGCGCCGGCCGCACCTGCCGTCCCCGTCCCGGGGGCGTGACTGCGNNCGTCGCTCCGCCA TGCTGACGCGGGCGGGCCCCGGCCGCNNGCGTTCGAGACGAACCCCCACCGNCTCTGCCT CGGNTGCACCGCCGCCCANCGTGACAAAGGAGAACCCGGACGCGTCCCANAAAGGGCAGA GCTCGGCCCCAGTGCCAGAANGGCAAGGGCANATCGAGAAAAGAACCTGCCGGAGACCGC GCTCACCGGCGGGTCACATCCTGCCGCAAN >OriGene 3' read for NM_002583 unedited
NNCCGGTATATTATGGACCGCGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTTT TTTCTAAATAATAATATTTAATAGAAAAAAAATCTGTATAATTATTTAGAAGTAACTCTG TTTTTAAAATTTCAATGTTAGGAAGAAAATCCCTTAAATTTGAAATAGCGGAATATTCTC TCATATGAAAAAACTGTGTCCCAGTGTTATTCTTCAACTTAGAAATTAGGCAAAGTATTT TAGTACTATTTCTGCTTACATATTGTTTTGTATGAATGTTTTAAGTATGAATAATATTTT GGTTTTTAGTGTGCATGCTAATATAAAAATATGGATTTTTTTCTCCTACACTGACTTTGT ACACTTTCCAGGCCCGAAGAATAAAAAACTTTTAAAATATCCTGTGTTCACTAGCAAACC TTGGAACGATAAAAAAAGGTAGTACCTACATAAGAAATTTTACATTGAAATTACAATTGT ATGTTTTTCAGGAGTTAAAGTGATTCAATTTTTCAATATTCAAACACAAAATAGTAAATT TTTATTTACTATAGCACAATTCAAGTATTCTCTTAAATTTATATTTAGTCAACTAAAACA TGACAGTGACTTTATAAGAGCTTTCCTTTTAAAAGGTTGCTGTTATAAAAAAGTATGACT CTATTACTCTAAATGCTTAGAATAAGTGGAAAGAACAAATGACAGTAGACAAAAACCTTT ATGAGTGAGTCATCAACACATAAAAGGTTGCACACCTCAGTAATAGGACATGTGAAGGTA ACATCCCAAAAGTATTTGAACTCATGTAAACAAAGACTATGGTATTTCCTAGGGAGAAAA TGTNCTTCCCAGATAAAATATATTTCAACGGCTGTGACTTTTAACCATGTATTAGTTGGA TACCCN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002583 |
| Insert Size | 1750 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002583.2, NP_002574.2 |
| RefSeq Size | 1967 bp |
| RefSeq ORF | 1023 bp |
| Locus ID | 5074 |
| UniProt ID | Q96IZ0 |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017] |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity
,GARCIA, SA;PAVANELLI, AC;MELO, NC;NAGAI, MA;,
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
,PubMed ID 28259909
[PAWR]
|
|
ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma
,Thayyullathil, F;Rahman, A;Pallichankandy, S;Patel, M;,
FEBS Open Bio
[PAWR]
|
|
ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma
,null,
FEBS Open Bio
,PubMed ID 25349781
[PAWR]
|
|
Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells
,null,
Journal of Molecular Signaling
,PubMed ID 23442976
[PAWR]
|
|
The Akt inhibitor ISC-4 activates Prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
,null,
Clinical cancer research : an official journal of the American Association for Cancer Research
,PubMed ID 21555373
[PAWR]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202733 | PAWR (Myc-DDK-tagged)-Human PRKC, apoptosis, WT1, regulator (PAWR) |
CNY 3,656.00 |
|
| RC202733L1 | Lenti ORF clone of Human PRKC, apoptosis, WT1, regulator (PAWR), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC202733L2 | Lenti ORF clone of Human PRKC, apoptosis, WT1, regulator (PAWR), mGFP tagged |
CNY 5,890.00 |
|
| RC202733L3 | Lenti ORF clone of Human PRKC, apoptosis, WT1, regulator (PAWR), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC202733L4 | Lenti ORF clone of Human PRKC, apoptosis, WT1, regulator (PAWR), mGFP tagged |
CNY 5,890.00 |
|
| RG202733 | PAWR (tGFP-tagged) - Human PRKC, apoptosis, WT1, regulator (PAWR) |
CNY 4,370.00 |
|
| SC320836 | PAWR (untagged)-Human PRKC, apoptosis, WT1, regulator (PAWR) |
CNY 2,950.00 |
