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Metabotropic Glutamate Receptor 8 (GRM8) (NM_000845) Human Untagged Clone
CAT＃: SC110911
GRM8 (untagged)-Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1
CNY 6,656.00
CNY 7,220.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GLUR8; GPRC1H; mGlu8; MGLUR8 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_000845 edited
ATGGTATGCGAGGGAAAGCGATCAGCCTCTTGCCCTTGTTTCTTCCTCTTGACCGCCAAG TTCTACTGGATCCTCACAATGATGCAAAGAACTCACAGCCAGGAGTATGCCCATTCCATA CGGGTGGATGGGGACATTATTTTGGGGGGTCTCTTCCCTGTCCACGCAAAGGGAGAGAGA GGGGTGCCTTGTGGGGAGCTGAAGAAGGAAAAGGGGATTCACAGACTGGAGGCCATGCTT TATGCAATTGACCAGATTAACAAGGACCCTGATCTCCTTTCCAACATCACTCTGGGTGTC CGCATCCTCGACACGTGCTCTAGGGACACCTATGCTTTGGAGCAGTCTCTAACATTCGTG CAGGCATTAATAGAGAAAGATGCTTCGGATGTGAAGTGTGCTAATGGAGATCCACCCATT TTCACCAAGCCCGACAAGATTTCTGGCGTCATAGGTGCTGCAGCAAGCTCCGTGTCCATC ATGGTTGCTAACATTTTAAGACTTTTTAAGATACCTCAAATCAGCTATGCATCCACAGCC CCAGAGCTAAGTGATAACACCAGGTATGACTTTTTCTCTCGAGTGGTTCCGCCTGACTCC TACCAAGCCCAAGCCATGGTGGACATCGTGACAGCACTGGGATGGAATTATGTTTCGACA CTGGCTTCTGAGGGGAACTATGGTGAGAGCGGTGTGGAGGCCTTCACCCAGATCTCGAGG GAGATTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGA GAATTTGAAAAAATTATCAAACGCCTGCTAGAAACACCTAATGCTCGAGCAGTGATTATG TTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGT GGGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAG CAAGAGGAGATTGCAGAAGGGGCTGTGACAATTTTGCCCAAACGAGCATCAATTGATGGA TTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCA GAATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCAT ATAAAGAAATGCACAGGGCTGGAGCGAATTGCTCGGGATTCATCTTATGAACAGGAAGGA AAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCAC AAAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAA GAGCTACTTGGTTATATTCGGGCTGTAAATTTTAATGGCAGTGCTGGCACTCCTGTCACT TTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAAC AAAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAA GACATGCAGTGGGCTCATAGAGAACATACTCACCCGGCGTCTGTCTGCAGCCTGCCGTGT AAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGC TGTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAG AGACCCAACATGAACCGCACAGGCTGCCAGCTTATCCCCATCATCAAATTGGAGTGGCAT TCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTT GTGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAA CTTAGTTACGTGCTCCTAACGGGGATTTTTCTCTGTTATTCAATCACGTTTTTAATGATT GCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGT TTCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGG AAGAAATCTGTCACAGCGCCCAAGTTCATTAGTCCAGCATCTCAGCTGGTGATCACCTTC AGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCAC ATCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTC AAGTGTGACATTTCTGATCTCTCACTCATTTGTTCACTTGGATACAGTATCCTCTTGATG GTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCC AAACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATC TTTTTTGGTACAGCCCAGTCAGCAGAAAAGATGTACATCCAGACAACAACACTTACTGTC TCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATT ATAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTG ACAGCTGCCACCATGCAAAGCAAACTGATCCAAAAAGGAAATGACAGACCAAATGGCGAG GTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACACTTCCTCTACCAAGACAACATAT ATCAGTTACAGCAATCATTCAATCTGA >OriGene 5' read for NM_000845 unedited
GGGGTTTGGGGCCCACNNNNTTTTTTCCNNNNNGNGGTTCANATTTGTNATACAACTCAC TATAGGCGGCCGCGNAATTCGCACGAGCTCAGTGGTGCCCTTTCTTCTGTGGCAAGAATA AACTTTGGGTCTTGGATTGCAATACCACCTGTGGAGAAAATGGTATGCGAGGGAAAGCGA TCAGCCTCTTGCCCTTGTTTCTTCCTCTTGACCGCCAAGTTCTACTGGATCCTCACAATG ATGCAAAGAACTCACAGCCAGGAGTATGCCCATTCCATACGGGTGGATGGGGACATTATT TTGGGGGGTCTCTTCCCTGTCCACGCAAAGGGAGAGAGAGGGGTGCCTTGTGGGGAGCTG AAGAAGGAAAAGGGGATTCACAGACTGGAGGCCATGCTTTATGCAATTGACCAGATTAAC AAGGACCCTGATCTCCTTTCCAACATCACTCTGGGTGTCCGCATCCTCGACACGTGCTCT AGGGACACCTATGCTTTGGAGCAGTCTCTAACATTCGTGCAGGCATTAATAGAGAAAGAT GCTTCGGATGTGAAGTGTGCTAATGGAGATCCACCCATTTTCACCAAGCCCGACAAGATT TCTGGCGTCATAGGTGCTGCAGCAAGCTCCGTGTCCATCATGGTTGCTAACATTTTAAGA CTTTTTAAGATACCTCAAATCAGCTATGCATCCACAGCCCCAGAGCTAAGTGATAACACC AGGTATGACTTTTTCTCTCGAGTGGTTCCGCCTGACTCCTACCAAGCCAAGCCATGGTGG ACATCGTGACAGCACTGGGATGGAATTATGTTTCGACACTGGCTTCTGAGGGGAAACTAT GNTGAGAGCGTGTGGAGGCCTTCACCCAGATCTCGAGGGAGATTGNNTGGTGTTTGCATT GCTCAGTCCAGAAAATCCCACCGTGACCCAAGACTGNAGAATTTGAAAAATTATCAACCC >OriGene 3' read for NM_000845 unedited
TTACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT AACATTTGCAAAACATTCCTTTATTATTAGAAATAAATTATTTGTATAAAAAATTGCATG CATCAATCATTGCATTTATTTTTAGCACAACCCAGGGCTTCAATCTGGTCAGCCATTACA AGAAACAGACTCATTGTCTTATACAAGTTAAACAATGTGGGACAGGAACGGGAGTTCTCA CAATCACAGAAAAATACAAGAATAACATCAGACATTATTTATTTCAACAGCATTTTTTTT CACGAGCTAACATTAGTTTTCCTTTTGGGATTTGTTTTAACTGCTCATGAATAAGCAATA CTTTAGCTTGACACTCATTGGTTTTATTGGATAAAACGGGTTTCTTCACTCCCCGTTTAT TGATACTTTTGGCTCATGGCTAATTTTTGTTCCTTACAAGACTGACTATTGATTTGATTG ATTGTAGTCTACGGAGATCTCCAGGAGTGAATTTTTGCGGGCTCATGTTCATCATTTAAG ATCATATACCACATCTCTTCAGATTGTGCCATTTCCCTGTTTCAGATTGAATGATTGCTG TAACTGATATATGTTGTCTTGGTAGAGGAAGTGTTGGTTTCAAGACTCTCACAGAGTTCA CTTTTCACCTCGCCATTTGGTCTGGCATTTCCTTTTTGGATCAGTTTGCTTTGCATGGGG GCAGCTGTCACCACAGCCTTGAAGCTCCTCTTGCGTTTTTGACATTCTGTTCTGGATGAA AATTATATATAAACCTTGGCATATAGAGCATGCCCAGAGAACTGAAGCACTTAACTCATG AAAACGAAGTGGTGGTGCCTGGAGAACACTTTTCGGTGACTGGCTGTCCCAAAAAGAGGG GAGAAAGCTACCAATGAGCCGGTGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000845 |
| Insert Size | 3630 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000845.1, NP_000836.1 |
| RefSeq Size | 3321 bp |
| RefSeq ORF | 2727 bp |
| Locus ID | 2918 |
| UniProt ID | O00222 |
| Domains | 7tm_3, ANF_receptor |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes isoform a. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
An endogenous and ectopic expression of metabotropic glutamate receptor 8 (mGluR8) inhibits proliferation and increases chemosensitivity of human neuroblastoma and glioma cells
,Jantas, D;Grygier, B;Gołda, S;Chwastek, J;Zatorska, J;Tertil, M;,
Cancer Lett.
,PubMed ID 29885518
[GRM8]
|
|
Ecdysone-Based System for Controlled Inducible Expression of Metabotropic Glutamate Receptor Subtypes 2, 5, and 8
,Patrick. M. Downey, Gianluca Lozza, Roberta Petrò, Enrica Diodato, Chiara Foglia, Federica Bottazzoli, Rossella Brusa, Tatiana Asquini, Angelo Reggiani, and Mariagrazia Grilli,
J Biomol Screen 2005 Dec;10(8):841-8.
[GRM8]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210813 | GRM8 (Myc-DDK-tagged)-Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1 |
CNY 6,648.00 |
|
| RC210813L1 | Lenti ORF clone of Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1, Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC210813L2 | Lenti ORF clone of Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1, mGFP tagged |
CNY 9,030.00 |
|
| RC210813L3 | Lenti ORF clone of Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1, Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC210813L4 | Lenti ORF clone of Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1, mGFP tagged |
CNY 9,030.00 |
|
| RG210813 | GRM8 (tGFP-tagged) - Human glutamate receptor, metabotropic 8 (GRM8), transcript variant 1 |
CNY 7,890.00 |
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