MNK1 (MKNK1) (AB000409) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	MNK1
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene ORF sequence for AB000409 edited ATGGTATCTTCTCAAAAGTTGGAAAAACCTATAGAGATGGGCAGTAGCGAACCCCTTCCC ATCGCAGATGGTGACAGGAGGAGGAAGAAGAAGCGGAGGGGCCGGGCCACTGACTCCTTG CCAGGAAAGTTTGAAGATATGTACAAGCTGACCTCTGAATTGCTTGGAGAGGGAGCCTAT GCCAAAGTTCAAGGTGCCGTGAGCCTACAGAATGGCAAAGAGTATGCCGTCAAAATCATC GAGAAACAAGCAGGGCACAGTCGGAGTAGGGTGTTTCGAGAGGTGGAGACGCTGTATCAG TGTCAGGGAAACAAGAACATTTTGGAGCTGATTGAGTTCTTTGAAGATGACACAAGGTTT TACTTGGTCTTTGAGAAATTGCAAGGAGGTTCCATCTTAGCCCACATCCAGAAGCAAAAG CACTTCAATGAGCGAGAAGCCAGCCGAGTGGTGCGGGACGTTGCTGCTGCCCTTGACTTC CTGCATACCAAAGGCATTGCTCATCGTGATCTGAAACCAGAAAATATATTGTGTGAATCT CCAGAAAAGGTGTCTCCAGTGAAAATCTGTGACTTTGACTTGGGCAGTGGGATGAAACTG AACAACTCCTGTACCCCCATAACCACACCAGAGCTGACCACCCCATGTGGCTCTGCAGAA TACATGGCCCCTGAGGTAGTGGAGGTCTTCACGGACCAGGCCACATTCTACGACAAGCGC TGTGACCTGTGGAGCCTGGGCGTGGTCCTCTACATCATGCTGAGTGGCTACCCACCCTTC GTGGGTCACTGCGGGGCCGACTGTGGCTGGGACCGGGGCGAGGTCTGCAGGGTGTGCCAG AACAAGCTGTTTGAAAGCATCCAGGAAGGCAAGTATGAGTTTCCTGACAAGGACTGGGCA CACATCTCCAGTGAAGCCAAAGACCTCATCTCCAAGCTCCTGGTGCGAGATGCAAAGCAG AGACTTAGCGCCGCCCAAGTTCTGCAGCACCCATGGGTGCAGGGGCAAGCTCCAGAAAAG GGACTCCCCACGCCGCAAGTCCTCCAGAGGAACAGCAGCACAATGGACCTGACGCTCTTC GCAGCTGAGGCCATCGCCCTTAACCGCCAGCTATCTCAGCACGAAGAGAACGAACTAGCA GAGGAGCCAGAGGCACTAGCTGATGGCCTCTGCTCCATGAAGCTTTCCCCTCCCTGCAAG TCACGCCTGGCCCGGAGACGGGCCCTGGCCCAGGCAGGCCGTGGTGAAGACAGGAGCCCG CCCACAGCACTCTGA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AB000409 unedited CGTGCAGNATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCCGCGTTC TCGGAGGAGCGATCTGCAGGTTTCCATGTCAGAGGCCGATGGAGAACTGAAGATTGCCAC CTACGCACAAAGGCCATTGAGACACTTCGTGTAGCTGGAAGACACCAACTTCCTGACAGG AGCTTTATTTCATTTGGGATTTCAAGTTTACAGATGGTATCTTCTCAAAAGTTGGAAAAA CCTATAGAGATGGGCAGTAGCGAACCCCTTCCCATCGCAGATGGTGACAGGAGGAGGAAG AAGAAGCGGAGGGGCCGGGCCACTGACTCCTTGCCAGGAAAGTTTGAAGATATGTACAAG CTGACCTCTGAATTGCTTGGAGAGGGAGCCTATGCCAAAGTTCAAGGTGCCGTGAGCCTA CAGAATGGCAAAGAGTATGCCGTCAAAATCATCGAGAAACAAGCAGGGCACAGTCGGAGT AGGGTGTTTCGAGAGGTGGAGACGCTGTATCAGTGTCAGGGAAACAAGAACATTTTGGAG CTGATTGAGTTCTTTGAAGATGACACAAGGTTTTACTTGGTCTTTGAGAAATTGCAAGGA GGTTCCATCTTAGCCCACATCCAGAAGCAAAAGCACTTCAATGAGCGAGAAGCCAGCCGA GTGGTGCGGGACGTTGCTGCTGCCCTTGACTTCCTGCATACCAAAGGCATTGCTCATCGT GATCTGAAACCAGAAAATATATTGTGTGAATCTNCAGAAAAGGTGTCTCCAGTGAAAATC TGTGACTTTGACTTGNGCAGTGGGATGAAACTGAACAACTCCTGTACCCCCATAACCACA CCAGAGCTGACCACCCCATGTGGCTCTGCAGATACATGGCNNCCTGAGTAGTGGAGGGTC TCACGGACCANGCCACATT 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AB000409 unedited GCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTAGAATTTCAGTTTTATTAAAAT AAGCACAATGTATAAAAGCACCGTGGTGTTGTATAAACGTCTGCCTGACAAATGCAAATC TATTTTCTTTATGTAACTCAATAGTTCCACTTATCTGAATGGCTGTACCTTCATGCACAC GGGCAGCAGGCACTGCATTGCTCAAACAGGGAAGTGAGGCTTCACCCTAGTGTGGCTTCA CCTTAGGCACAGAGCACTATCTAACTGCCCAGATCTGTGCCACCCACACAAGACCTGGGG ACACAGCAGCAGACACCGATGCTGTCTCTAAGTTCATCACAGGAACAGCTTAAAATCAGA ATAATAGGGAACTGCTGATTAAAACCCAAGTGCATGGACATTCTAGAAAGAAGAGCAAGC CGTTCCACTCTCTGGGAAGTTCATGGGCTTGCAGTGGGAGTTTAAGGTATCATCTTTGCT GGAACAGCATGGTTAAAAACACCAAACTTTTTTTTTAAAAAAACGATACTACTGACTTTA GCAGCAATCACAAACAAAGGGGATGATAAACGAGGGATACATTTCAGTCACAGCAAAGAA AGATTATGTGCTTTTCCGTGCTGCAAACCGGAAGACTGATTTGATTCCCTGAATGACGAA CGCTCCCTGCCCCTTCCTGATTGAGGGGATGGCTCTGCTCACCCCAAGGAGAATACGGCC AAAAAGACATCCCGAGGACAAAAGAAGGTGGTAAGACCCCCATAGGAGGGGACCCAAAAT AGAGGGACGAGCCCCTGTCGGCAACCTTTGAAACTGAGGCTTTTGCCTTTCCCTGAAGGT GGAACCCCCAACCCCCCAACTACCACGGTGAAGAGAAGCTTGTATCCACAATCTTGGAGG GGGTGAACAGGGCGAGACCCACAGAAAAAAATTTCTTCGTCCACCGCAATCATCCCAAGA GAATAGGATGGCTTTCCCTTTCAAAAAAACCACTTCGAGAAAG
Restriction Sites	NotI-NotI
ACCN	AB000409
Insert Size	2740 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	AB000409.1, BAA19885.1
RefSeq Size	2617 bp
RefSeq ORF	1275 bp
Locus ID	8569
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Insulin signaling pathway, MAPK signaling pathway
Gene Summary	This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

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