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Lamin A (LMNA) (NM_170707) Human Untagged Clone
CAT＃: SC101048
LMNA (untagged)-Human lamin A/C (LMNA), transcript variant 1
CNY 4,952.00
CNY 7,220.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC101048 sequence for NM_170707 edited (data generated by NextGen Sequencing)
ATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCCG CTGTCGCCCACCCGCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGAT CGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGGAGAACGCAGGGCTGCGC CTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGCC TACGAGGCCGAGCTCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGCC CGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGGAGCTGAAAGCGCGCAAT ACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCTG CTGAACTCCAAGGAGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGC GAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGCTTGAGGCAGCCCTAGGTGAGGCCAAG AAGCAACTTCAGGATGAGATGCTGCGGCGGGTGGATGCTGAGAACAGGCTGCAGACCATG AAGGAGGAACTGGACTTCCAGAAGAACATCTACAGTGAGGAGCTGCGTGAGACCAAGCGC CGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGCGTGAGTTTGAGAGCCGG CTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAG AAGGAGCTGGAGAAGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGG AACAGCAACCTGGTGGGGGCCGCCCACGAGGAGCTGCAGCAGTCGCGCATCCGCATCGAC AGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTT CGAGACCTGGAGGACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAA AAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGCAGCTGGACGAGTACCAG GAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTG GAGGGCGAGGAGGAGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGC CGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCGTCACCAAAAAGCGCAAA CTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTG GCCGTGGAGGAGGTGGACGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAG GACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAGATGATCCCTTGCTGACT TACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCA GGAGCTGGGGCCACCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGG GGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTGGGGAAGAAGTGGCCATG CGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGAC CTGCTCCATCACCACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAAC CTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTGCCGACAAGGCATCTGCC AGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTC ACGGTCACTCGCAGCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAAT CTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAACCCAGAGCCCCCAGAAC TGCAGCATCATGTAA Clone variation with respect to NM_170707.2 861 t=>c;1338 t=>c >OriGene 5' read for NM_170707 unedited
GGATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGCACCTACA CCAGCCAACCCANATCCCGAGGTCCGACAGCGCCCGGCCCAGATCCCCACGCCTGCCAGG AGCAAGCCGAGAGCCAGCCGGCCGGCGCACTCCGACTCCGAGCAGTCTCTGTCCTTCGAC CCGAGCCCCGCGCCCTTTCCGGGACCCCTGCCCCGCGGGCAGCGCTGCCAACCTGCCGGC CATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCC GCTGTCGCCCACCCGCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGA TCGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGGAGAACGCAGGGCTGCG CCTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGC CTACGAGGCCGAGCTCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGC CCGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGGAGCTGAAAGCGCGCAA TACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCT GCTGAACTCCAAGAGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGC GAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGCTTGAGGCAGCCCTAGGTGAGGCCCAG AAAGCACTTCAGGATGAAATGCTGCGGCGGGTGGATGCTGANAACCAGCTGCACACATTG AGGAGGACTGGACTCCAGAAGACATCC >OriGene 3' read for NM_170707 unedited
ACATTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCTTGTGTTTTTCCTTCGTATAAAACCA CTGTAGAAAATAACTTCTCTTAGAAAAAAAAATACAGAAGAAAAAAACCAAAGGGTTATT TTTCTTTGGCTTCAAGCCCCCTCCCATGAGGTGCAGGGCAGGGGGTGGGCATGAGGTGAG GAGGACGCAGGAAGCCTCCACCCCCACCCCTGCCTGGCAGGTCCCAGATTACATGATGCT GCAGTTCTGGGGGCTCTGGGTTCGGGGGCTGGAGTTGCCCAGGAGGTAGGAGCGGGTGAC CAGATTGTCCCCGAAGCTGCCACCCCCACTGCCCCCCACACTGCGGTAGCTGCGAGTGAC CGTGACACTGGAGGCAGAAGAGCCAGAGGAGATGGGTCCGCCCACCTGGGCTCCTGAGCC GCTGGCAGATGCCTTGTCGGCAGGCTGCCCGCAGGTCCCGCACAGCACGGTGCGCGAGCG CAGGTTGTACTCAGCGGGGTCCCCCGAGCTGCTGCAGTGGGAGCCGTGGTGGTGATGGAG CANGTCATCTCCATCCTCATCCTCGTCGTCCTCAACCACAGTCACTGAGCGCACCAGCTT GCGCATGGCCACTTCTTCCCCAGTGGGAGTGATGAGAGCCGTACGCAGGGCTGTTCCGCA GCCCCAGTTGTTCTGTGCCCTTCACACCAGGTCGGTAAGGGGGCTGTGGGTGGCCCCAAC TCCTTGCAGCCAGATCGTNACCACCTGCCCACCCTTCAGGGTGAACTTTGGTGGGGAACG GTAATTACCAAGGGATCATCTCCCATTCCGCCCCTTGATTTGGCCAATGCCAATGGAATG GGCCTAATTGGACTTGTTGCCCCACCGGACACAATTGGCTCTCCCGTCCTCTTCTTTCCG GCCCTCCCCCCCCCATCGGTCGTGTCTGTATACACCCCTTGCGCCCTCACAGTCCTCCCA TGTGCCCCTTTCCGGACCCTTCGCCACATTCTGTTTGCGCCCCCGCCACAGAAACACGTT TTCTCCCCCCAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_170707 |
| Insert Size | 2560 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_170707.1, NP_733821.1 |
| RefSeq Size | 3181 bp |
| RefSeq ORF | 1995 bp |
| Locus ID | 4000 |
| UniProt ID | P02545 |
| Protein Families | Druggable Genome |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
| Gene Summary | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012] Transcript Variant: This variant (1) encodes isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures
,Chen, NY;Kim, P;Weston, TA;Edillo, L;Tu, Y;Fong, LG;Young, SG;,
Proc. Natl. Acad. Sci. U.S.A.
,PubMed ID 30224463
[LMNA]
|
|
Disrupting the LINC Complex in Smooth Muscle Cells Reduces Aortic Disease in a Mouse Model of HGPS
,null,
Science translational medicine
,PubMed ID 30257952
[LMNA]
|
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204970 | LMNA (Myc-DDK-tagged)-Human lamin A/C (LMNA), transcript variant 1 |
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| RC204970L1 | Lenti ORF clone of Human lamin A/C (LMNA), transcript variant 1, Myc-DDK-tagged |
CNY 9,816.00 |
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| RC204970L2 | Lenti ORF clone of Human lamin A/C (LMNA), transcript variant 1, mGFP tagged |
CNY 9,816.00 |
|
| RC204970L3 | Lenti ORF clone of Human lamin A/C (LMNA), transcript variant 1, Myc-DDK-tagged |
CNY 9,816.00 |
|
| RC204970L4 | Lenti ORF clone of Human lamin A/C (LMNA), transcript variant 1, mGFP tagged |
CNY 9,816.00 |
|
| RG204970 | LMNA (tGFP-tagged) - Human lamin A/C (LMNA), transcript variant 1 |
CNY 9,016.00 |
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