United States
Germany
Japan
United Kingdom
China
Lair1 (NM_001029928) Rat Tagged ORF Clone
CAT＃: RR201965
- TrueORF®
Lair1 (Myc-DDK-tagged ORF) - Rat leukocyte-associated immunoglobulin-like receptor 1 (Lair1), (10 ug)
"NM_001029928" in other vectors (3)
Need custom modification / cloning service?
Get a free quote
CNY 3,990.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Rat Tagged ORF Clone |
| Tag | Myc-DDK |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RR201965 representing NM_001029928
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCCACTTCATTCTGTCATCGTGCTGGTGCTTGTACTGTGCCTGGGATGGAAAAGTAACACACAGGAGG AATCTCTGTCCGATTTCACTATCTGCGCTGAGCCAGGTCCTGTGATTCCTCAAGGGAATTTCATAACCAT TGTGTGCTCAACCTCTGGTGAATATGACACGGTCCGCCTGGAGAAGGAAGGCAGCACCTTTATGGAAAAG AAAACAGAGCCTCATGGAAAACAGCATAGATTCCGTATTGGGCCAGTGAATGAAACCATTACTGGATATT ATAACTGTATCTTTGAAAAAAATTATGTATGGTCTCAACGAAGTAATGATCTGCAGCTAAAAGTGATCAA AGAAAATGTCACCCAGGGTCTTGCCCCAGGTCCATCAATGACCTCAGATACATCTTGGCTGAAGACGTAC AGCATTCACATTCTTACTGTGGTCTCTGTGATTTTCCTCCTTTGTCTTTCCCTCTTTCTATTCTGCTTTC TTAGCCACCGTCAGAAAAAGCAGGGACTTCCAAACAATAAGAGCCAGCATCAGAGGTCACAGGAGAGGCT CAACCTAGCTACTAATGGCCTGGAGAAGACATCAGACATAGTCATGGATGACAGCCTTTCTGAGGACAGA CAGACAGAAACTTGGACCCCAGTTGCAGGAGATCTTCAGGAGGTGACATATGCCCAGCTGGACCATGACT CCCTCACACAAAGGACTGTTAAAGATGTGACCCCACAGAACAGAGTTATCATGGCTGAGTCCAGTACATA TGCAGCCATCATGAGATGCTGCAGCCATCATGAGATGC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RR201965 representing NM_001029928
Red=Cloning site Green=Tags(s) MPLHSVIVLVLVLCLGWKSNTQEESLSDFTICAEPGPVIPQGNFITIVCSTSGEYDTVRLEKEGSTFMEK KTEPHGKQHRFRIGPVNETITGYYNCIFEKNYVWSQRSNDLQLKVIKENVTQGLAPGPSMTSDTSWLKTY SIHILTVVSVIFLLCLSLFLFCFLSHRQKKQGLPNNKSQHQRSQERLNLATNGLEKTSDIVMDDSLSEDR QTETWTPVAGDLQEVTYAQLDHDSLTQRTVKDVTPQNRVIMAESSTYAAIMRCCSHHEM TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001029928 |
| ORF Size | 789 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq Size | 854 bp |
| RefSeq ORF | 792 bp |
| Locus ID | 574531 |
| UniProt ID | P0C1X9 |
| MW | 29.7 kDa |
| Gene Summary | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RN201965 | Lair1 (untagged ORF) - Rat leukocyte-associated immunoglobulin-like receptor 1 (Lair1), (10 ug) |
CNY 3,990.00 |
|
| RR201965L3 | Lenti ORF clone of Lair1 (Myc-DDK-tagged ORF) - Rat leukocyte-associated immunoglobulin-like receptor 1 (Lair1), (10 ug) |
CNY 6,080.00 |
|
| RR201965L4 | Lenti ORF clone of Lair1 (mGFP-tagged ORF) - Rat leukocyte-associated immunoglobulin-like receptor 1 (Lair1), (10 ug) |
CNY 6,650.00 |
