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ITGA8 (NM_001291494) Human Tagged ORF Clone
CAT＃: RG239915
- TrueORF®
ITGA8 (tGFP-tagged) - Human integrin, alpha 8 (ITGA8), transcript variant 2
ORF Plasmid: DDK
"NM_001291494" in other vectors (2)
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CNY 10,830.00
货期*
2周
规格
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经常一起买 (5)
Specifications
| Product Data | |
| Tag | TurboGFP |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG239915 representing NM_001291494.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGTCGCCCGGGGCCAGCCGCGGTCCCCGGGGAAGCCAGGCGCCGCTGATCGCGCCCCTCTGCTGCGCC GCGGCCGCGCTGGGGATGTTGCTGTGGTCCCCCGCCTGTCAGGCGTTCAACCTGGACGTGGAAAAGCTC ACAGTGTACAGCGGCCCCAAGGGCAGCTACTTCGGCTACGCCGTGGACTTCCACATACCCGACGCCCGC ACAGCGAGTGTCTTGGTGGGGGCGCCCAAAGCCAACACCAGCCAGCCCGATATCGTGGAAGGGGGAGCC GTCTATTACTGTCCTTGGCCCGCGGAGGGGTCTGCGCAGTGCAGGCAGATACCGTTTGACACCACCAAC AACAGAAAGATCAGAGTTAATGGAACCAAAGAACCTATCGAGTTCAAATCCAATCAGTGGTTTGGAGCA ACAGTGAAAGCTCACAAAGGAAAAGTTGTGGCCTGTGCTCCTTTATATCACTGGAGAACTCTTAAACCG ACACCAGAAAAGGACCCAGTTGGCACCTGCTATGTAGCAATTCAGAACTTCAGCGCCTATGCCGAGTTC TCTCCTTGCCGGAACAGCAATGCTGATCCGGAAGGCCAGGGTTACTGCCAAGCAGGATTTAGTCTGGAT TTTTATAAGAATGGAGACCTTATTGTGGGAGGACCTGGGAGTTTCTACTGGCAAGGACAAGTGATCACT GCCAGTGTTGCAGATATCATTGCAAATTACTCATTCAAGGATATCCTCAGGAAACTGGCAGGAGAAAAG CAGACGGAAGTGGCTCCAGCTTCCTATGATGACAGTTACCTTGAATTGGTTGCTGGAATTCCAAGAGGA GCACAGAATTTTGGATATGTTTCCATCATTAACTCTACGGATATGACGTTTATTCAGAATTTCACGGGA GAACAGATGGCATCTTATTTTGGATATACCGTTGTCGTATCAGATGTTAACAGTGATGGACTGGATGAT GTCCTGGTTGGGGCACCTCTCTTTATGGAACGTGAATTTGAGAGCAACCCCAGAGAAGTAGGGCAAATC TACCTGTATTTGCAAGTGAGCTCTCTCCTCTTCAGAGACCCCCAGATCCTCACTGGCACCGAGACGTTT GGGAGATTCGGTAGTGCTATGGCACACTTAGGAGACCTGAACCAAGATGGATACAATGACATTGCCATC GGAGTGCCTTTTGCAGGCAAGGATCAAAGAGGCAAAGTGCTCATTTATAATGGGAACAAAGATGGCTTA AACACCAAGCCTTCCCAAGTTCTGCAAGGAGTGTGGGCCTCACATGCTGTCCCTTCCGGATTTGGCTTT ACTTTAAGAGGAGATTCAGACATAGACAAGAATGATTACCCAGATTTGATTGTGGGTGCATTTGGAACA GGAAAAGTCGCTGTTTACAGAGCAAGACCGGTTGTGACTGTAGATGCCCAGCTTCTGCTGCACCCAATG ATTATCAATCTTGAAAATAAAACTTGCCAGGTTCCAGACTCTATGACATCTGCTGCCTGCTTTTCTTTA AGAGTATGTGCATCTGTCACAGGCCAGAGCATTGCAAACACAATAGTCTTGATGGCAGAGGTGCAATTA GATTCCCTGAAACAGAAAGGAGCTATTAAACGGACGCTCTTCCTTGATAACCATCAGGCTCATCGCGTC TTCCCTCTTGTGATAAAAAGGCAGAAATCCCACCAGTGCCAGGATTTCATCGTTTACCTTCGAGATGAA ACTGAATTCCGAGATAAATTATCTCCAATCAACATTAGTTTGAATTACAGTTTGGACGAATCCACCTTT AAAGAAGGCCTGGAAGTGAAACCAATATTGAACTACTACAGAGAAAACATTGTTAGTGAACAGGCTCAC ATTCTGGTGGACTGTGGAGAAGACAATCTGTGTGTTCCTGACTTGAAGCTGTCGGCTAGACCAGATAAG CATCAGGTAATCATTGGAGATGAAAATCACCTTATGCTCATAATAAATGCAAGAAATGAAGGGGAAGGA GCATATGAAGCTGAACTCTTTGTAATGATACCAGAAGAGGCAGATTATGTTGGAATCGAACGCAACAAC AAGGGATTTCGACCACTGAGCTGTGAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTT GGGAACCCTATGGTGTCTGGAACAAATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAA ACAAACATGAGCATTAACTTCGATCTCCAAATCAGAAGTTCCAACAAGGACAATCCAGACAGCAATTTT GTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGTGTCACACCCTCCGCAG ATTGTTCTGCCCATTCATAACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTG GTGGAACATATTTATGAGCTGCACAATATTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGC TGGCCTTTCTCTGCCCGGGATGAATTTCTTCTCTATATTTTCCATATTCAAACTCTGGGACCTCTGCAG TGCCAACCAAATCCTAATATCAATCCACAGGATATAAAGCCTGCTGCCTCCCCAGAGGACACCCCTGAG CTCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAA TTCCACAGACAGAGCCCTGCAAAAATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCA GTGGGACGACTCGAAGGAGGAGAAAGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTC CTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGTGTCCTTTGAAGTTAAGAAGATGCCTTAT ACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGACATCAGTTATTTGGGCAACTCCG AATGTTTCCTTCTCAATCCCATTATGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCC ATTTTAACCTTAGCTTTATGGAAGTGTGGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGACC GACAGGGAACAGCTGACAAATGACAAGACCCCTGAGGCA ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG239915
Blue=ORF Red=Cloning site Green=Tag(s) MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDAR TASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGA TVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLD FYKNGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLELVAGIPRG AQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQI YLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGL NTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPM IINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRV FPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAH ILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNN KGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNF VSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVG WPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVE FHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPY TDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMT DREQLTNDKTPEA TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001291494 |
| ORF Size | 3144 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001291494.1, NP_001278423.1 |
| RefSeq Size | 6937 bp |
| RefSeq ORF | 3147 bp |
| Locus ID | 8516 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton |
| MW | 116.4 kDa |
| Gene Summary | Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014] |
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