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CIITA (NM_001286403) Human Tagged ORF Clone
CAT＃: RG238840
- TrueORF®
CIITA (tGFP-tagged) - Human class II, major histocompatibility complex, transactivator (CIITA), transcript variant 3
ORF Plasmid: DDK
"NM_001286403" in other vectors (2)
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CNY 5,800.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Tag | TurboGFP |
| Synonyms | C2TA; CIITAIV; MHC2TA; NLRA |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001286403 |
| ORF Size | 1638 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001286403.2 |
| RefSeq Size | 2902 bp |
| RefSeq ORF | 1641 bp |
| Locus ID | 4261 |
| UniProt ID | P33076 |
| Protein Pathways | Antigen processing and presentation, Primary immunodeficiency |
| MW | 60.1 kDa |
| Gene Summary | This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC238840 | CIITA (myc-DDK-tagged) - Human class II, major histocompatibility complex, transactivator (CIITA), transcript variant 3 |
CNY 5,420.00 |
|
| SC336734 | CIITA (untagged) - Human class II, major histocompatibility complex, transactivator (CIITA), transcript variant 3 |
CNY 5,230.00 |
