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SIRP alpha (SIRPA) (NM_001040022) Human Tagged ORF Clone
CAT＃: RC222380
- TrueORF®
SIRPA (Myc-DDK-tagged)-Human signal-regulatory protein alpha (SIRPA), transcript variant 1
ORF Plasmid: tGFP
"NM_001040022" in other vectors (6)
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CNY 3,760.00
CNY 3,990.00
| Cited in 1 publication. |
Product images
CNY 300.00
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001040022 |
| ORF Size | 1515 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq Size | 4201 bp |
| RefSeq ORF | 1515 bp |
| Locus ID | 140885 |
| UniProt ID | P78324 |
| Protein Families | Druggable Genome, Phosphatase, Transmembrane |
| MW | 54.8 kDa |
| Gene Summary | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
,Leslie, KA;Russell, MA;Taniguchi, K;Richardson, SJ;Morgan, NG;,
Diabetologia
,PubMed ID 30338340
[SIRPA]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222380L1 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC222380L2 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC222380L3 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC222380L4 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG222380 | SIRPA (tGFP-tagged) - Human signal-regulatory protein alpha (SIRPA), transcript variant 1 |
CNY 4,370.00 |
|
| SC311067 | SIRPA (untagged)-Human signal-regulatory protein alpha (SIRPA), transcript variant 1 |
CNY 5,640.00 |
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