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GABA A Receptor gamma 2 (GABRG2) (NM_198904) Human Tagged ORF Clone
CAT＃: RC209260
GABRG2 (Myc-DDK-tagged)-Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1
ORF Plasmid: tGFP
"NM_198904" in other vectors (6)
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CNY 3,656.00
CNY 3,990.00
| Cited in 5 publications. |
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | CAE2; DEE74; ECA2; EIEE74; FEB8; GEFSP3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC209260 representing NM_198904
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAGTTCGCCAAATATATGGAGCACAGGAAGCTCAGTCTACTCGACTCCTGTATTTTCACAGAAAATGA CGGTGTGGATTCTGCTCCTGCTGTCGCTCTACCCTGGCTTCACTAGCCAGAAATCTGATGATGACTATGA AGATTATGCTTCTAACAAAACATGGGTCTTGACTCCAAAAGTTCCTGAGGGTGATGTCACTGTCATCTTA AACAACCTGCTGGAAGGATATGACAATAAACTTCGGCCTGATATAGGAGTGAAGCCAACGTTAATTCACA CAGACATGTATGTGAATAGCATTGGTCCAGTGAACGCTATCAATATGGAATACACTATTGATATATTTTT TGCGCAAACGTGGTATGACAGACGTTTGAAATTTAACAGCACCATTAAAGTCCTCCGATTGAACAGCAAC ATGGTGGGGAAAATCTGGATTCCAGACACTTTCTTCAGAAATTCCAAAAAAGCTGATGCACACTGGATCA CCACCCCCAACAGGATGCTGAGAATTTGGAATGATGGTCGAGTGCTCTACACCCTAAGGTTGACAATTGA TGCTGAGTGCCAATTACAATTGCACAACTTTCCAATGGATGAACACTCCTGCCCCTTGGAGTTCTCAAGT TATGGCTATCCACGTGAAGAAATTGTTTATCAATGGAAGCGAAGTTCTGTTGAAGTGGGCGACACAAGAT CCTGGAGGCTTTATCAATTCTCATTTGTTGGTCTAAGAAATACCACCGAAGTAGTGAAGACAACTTCCGG AGATTATGTGGTCATGTCTGTCTACTTTGATCTGAGCAGAAGAATGGGATACTTTACCATCCAGACCTAT ATCCCCTGCACACTCATTGTCGTCCTATCCTGGGTGTCTTTCTGGATCAATAAGGATGCTGTTCCAGCCA GAACATCTTTAGGTATCACCACTGTCCTGACAATGACCACCCTCAGCACCATTGCCCGGAAATCGCTCCC CAAGGTCTCCTATGTCACAGCGATGGATCTCTTTGTATCTGTTTGTTTCATCTTTGTCTTCTCTGCTCTG GTGGAGTATGGCACCTTGCGTTATTTTGTCAGCAACCGGAAACCAAGCAAGGACAAAGATAAAAAGAAGA AAAACCCTCTTCTTCGGATGTTTTCCTTCAAGGCCCCTACCATTGATATCCGCCCAAGATCAGCAACCAT TCAAATGAATAATGCTACACACCTTCAAGAGAGAGATGAAGAGTACGGCTATGAGTGTCTGGACGGCAAG GACTGTGCCAGTTTTTTCTGCTGTTTTGAAGATTGTCGAACAGGAGCTTGGAGACATGGGAGGATACATA TCCGCATTGCCAAAATGGACTCCTATGCTCGGATCTTCTTCCCCACTGCCTTCTGCCTGTTTAATCTGGT CTATTGGGTCTCCTACCTCTACCTG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC209260 representing NM_198904
Red=Cloning site Green=Tags(s) MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVIL NNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSN MVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSS YGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTY IPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSAL VEYGTLRYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_198904 |
| ORF Size | 1425 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_198904.4 |
| RefSeq Size | 3871 bp |
| RefSeq ORF | 1428 bp |
| Locus ID | 2566 |
| UniProt ID | P18507 |
| Protein Families | Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| MW | 50.8 kDa |
| Gene Summary | This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Quantitative interactome proteomics identifies a proteostasis network for GABA A receptors
,null,
The Journal of Biological Chemistry
,PubMed ID 36030824
[GABA A Receptor gamma 2]
|
|
Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors
,Di, XJ;Wang, YJ;Cotter, E;Wang, M;Whittsette, AL;Han, DY;Sangwung, P;Brown, R;Lynch, JW;Keramidas, A;Mu, TW;,
Cell Chem Biol
,PubMed ID 32888501
[GABA A Receptor gamma 2]
|
|
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator
,Althaus, AL;Ackley, MA;Belfort, GM;Gee, SM;Dai, J;Nguyen, DP;Kazdoba, TM;Modgil, A;Davies, PA;Moss, SJ;Salituro, FG;Hoffmann, E;Hammond, RS;Robichaud, AJ;Quirk, MC;Doherty, JJ;,
Neuropharmacology
,PubMed ID 32976892
[GABA A Receptor gamma 2]
|
|
LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors
,Fu, YL;Zhang, B;Mu, TW;,
Biochem. Biophys. Res. Commun.
,PubMed ID 30791981
[GABA A Receptor gamma 2]
|
|
Grp94 Delivers ?-aminobutyric Acid Type A (GABAA) Receptors to Hrd1-Mediatd Endoplasmic Reticulum-Associated Degradation
,Di, XJ;Wang, YJ;Han, DY;Fu, YL;Duerfeldt, AS;Blagg, BS;Mu, TW;,
J. Biol. Chem.
,PubMed ID 26945068
[GABA A Receptor gamma 2]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209260L1 | Lenti ORF clone of Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209260L2 | Lenti ORF clone of Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC209260L3 | Lenti ORF clone of Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209260L4 | Lenti ORF clone of Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG209260 | GABRG2 (tGFP-tagged) - Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1 |
CNY 4,370.00 |
|
| SC307809 | GABRG2 (untagged)-Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1 |
CNY 3,656.00 |
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