United States
Germany
Japan
United Kingdom
China
Adcy8 (NM_009623) Mouse Untagged Clone
CAT＃: MC224054
Adcy8 (untagged) - Mouse adenylate cyclase 8 (Adcy8), (10ug)
CNY 16,060.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AC8; AW060868 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC224054 representing NM_009623
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCTCTCGGATGTGCACTGCCTTAGTGGCAGCGAGGAACTCTACACCATCCAACCGACGCCCCCGG CCGGCGACGACGGGAGCGGCTCTCGGCCGCAGCGGCTGCTGTGGCAGACGGCGGTGCGGCACATCACGGA GCAGCGCTTCATCCACGGGCACCGAGGCGGCGGCGGCGGCGGGGTCTCCCGCAAAGCCTCGAACCCTGCG GGCAGTGGACCCAATCACCACGCGCCGCAGCTGTCTAGCGACTCGGTGCTGCCTCTCTATTCTCTGGGCC CCGGAGAGCGAGCGCACAACACCGGTGGCACCAAAGTCTTTCCGGAACGCAGCGGGAGCGGCAGTGCCAG TGGCAGCGGGGGCGGGGGCGACTTGGGCTTCCTACACCTTGACTGTGCCCCAAGTAACTCGGATTTCTTC CTCAATGGAGGATACAGCTACCGAGGGGTCATTTTTCCAACCCTACGCAACTCCTTCAAGTCTCGGGATC TGGAGCGCCTCTACCAACGCTATTTCCTGGGCCAGAGGCGCAAATCGGAGGTAGTGATGAACGTGTTGGA TGTACTAACCAAACTCACCCTTTTAGTCCTGCACTTGAGCCTGGCCTCGGCTCCAATGGACCCTCTCAAG GGCATCCTGCTAGGCTTTTTCACTGGCATCGAGGTGGTGATCTGCGCCCTCGTGGTGGTCAGGAAGGACA ACACCTCCCACACTTACCTGCAATACAGCGGCGTGGTCACTTGGGTGGCTATGACCACCCAGATTCTGGC AGCAGGCCTGGGCTATGGGCTTCTGGGCGACGGCATAGGCTACGTGCTTTTTACACTCTTCGCCACCTAC AGCATGCTTCCCCTGCCTCTCACCTGGGCCATCTTGGCCGGCCTGGGCACATCTTTGCTGCAAGTCACCC TTCAAGTACTCATACCCAGGCTAGCGGTCTTTTCCATCAACCAGGTCCTGGCCCAGGTGGTGCTATTCAT GTGTATGAATACAGCAGGAATCTTCATCAGTTACCTTTCAGACCGTGCCCAGCGCCAGGCCTTCCTGGAG ACCCGGAGGTGTGTGGAGGCCAGGCTCCGCTTGGAGACAGAGAACCAAAGACAGGAGCGGCTTGTGCTGT CTGTGCTCCCCAGGTTTGTCGTCCTGGAAATGATCAACGACATGACCAATGTGGAGGATGAGCACCTGCA GCATCAGTTCCACCGCATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGCAGATGTCAAAGGA TTTACCAACCTCTCTACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAACGAACTCTTTGCCAGAT TCGACCGGCTGGCCCATGAGCATCACTGTCTTCGCATTAAAATCCTGGGGGACTGCTACTACTGTGTGTC TGGACTGCCTGAGCCCCGCCGGGACCACGCTCATTGCTGTGTTGAAATGGGCCTCAGCATGATCAAAACT ATCAGGTTTGTGAGATCCAGAACGAAGCACGATGTTGACATGCGAATTGGAATCCATTCAGGTTCTGTGC TATGTGGTGTGTTGGGCCTGAGGAAATGGCAGTTTGATGTCTGGTCTTGGGATGTGGACATAGCAAACAA GCTTGAGTCTGGAGGAATCCCTGGGAGGATTCACATTTCTAAAGCCACCCTGGATTGCCTCAATGGTGAC TATAACGTGGAAGAGGGTCACGGGAAAGAGAGGAACGAATTCTTGAGGAAGCATAACATAGAGACCTATT TGATTAAGCAGCCTGAGGAGAGTTTGCTCTGCTTGCCTGAAGACATCGTTAAGGAGTCGGTGAGCTGCTC TGACAGGAGAAACAGTGGAGCAACATTCACAGAAGGATCGTGGAGCCCAGAGCTGCCTTTCGACAACATC GTGGGCAAACAGAATACTCTGGCTGCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTCGCAC AAGCTTTGCATGTCCAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAGCATACCATCGACTTGCGGAG TGGCGATAAGTTGAGAAGAGAGCATATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTGGAGCAC AAGTATTCTCAAATGAGGGATGAAGTATTCAAGTCAAACTTGGTCTGTGCATTTATCGTTCTTCTGTTTA TCACTGCAATTCAAAGTTTGCTTCCTTCTTCAAGGCTGATGCCTATGACTATCCAGTTCTCCATCCTGAT CATGCTGCACTCTGCCCTGGTCCTCATCACCACAGCAGAAGACTATAAGTGTCTGCCCCTCATCCTCCGA AAAACCTGCTGTTGGATTAATGAGACCTATCTGGCCCGCAACGTCATCATCTTCGCTTCCATCTTAATTA ACTTCCTGGGAGCTGTCCTAAATATTCTGTGGTGTGATTTTGACAAGTCGATACCCTTGAAGAACCTGAC TTTCAATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTGTCTTCACTGGGGTGTTG GCCATGGTGACCTGTGCTGTGTTTCTACGGCTTAACTCTGTCCTGAAGCTGGCAGTGCTACTCATCATGA TCGCCATCTACGCCCTGCTCACAGAGACCATCTACGCAGGTCTCTTTCTGAGTTATGACAACCTGAACCA CAGTGGAGAAGATTTCCTGGGGACCAAGGAAGCATCACTGCTGCTGATGGCCATGTTCCTTCTTGCTGTG TTCTACCATGGACAACAGCTGGAGTACACAGCCCGCCTGGATTTCCTGTGGCGCGTACAGGCCAAAGAGG AGATCAACGAGATGAAGGAACTGAGGGAACACAACGAGAACATGCTGCGCAATATCTTACCCAGCCATGT GGCCCGCCACTTCCTGGAGAAAGACAGAGACAATGAGGAGCTGTATTCTCAATCCTACGATGCTGTTGGA GTGATGTTCGCCTCCATCCCTGGGTTCGCAGACTTCTACTCTCAGACAGAAATGAACAACCAGGGAGTAG AATGTCTGCGCTTGCTGAATGAGATCATTGCTGACTTTGATGAGCTGCTCGGGGAGGACCGGTTTCAGGA CATTGAGAAGATTAAGACCATTGGTAGTACATACATGGCTGTCTCAGGACTGTCCCCAGAGAAACAGCAA TGTGAAGATAAATGGGGACATTTGTGTGCCCTGGCTGACTTCTCTCTTGCTCTGACTGAAAGCATACAAG AGATCAACAAGCATTCATTCAACAATTTTGAACTCCGAATCGGCATCAGCCATGGCTCAGTGGTGGCAGG TGTAATTGGAGCTAAGAAACCACAGTATGACATTTGGGGGAAAACTGTGAACTTGGCAAGCCGAATGGAC AGCACGGGAGTAAGTGGCCGGATCCAAGTTCCTGAGGAGACCTACCTTATCCTGAAGGACCAGGGCTTTG CCTTTGACTACCGTGGGGAGATATATGTGAAGGGCATCAGTGAACAAGAAGGGAAAATCAAAACATACTT TCTCCTGGGACGAGTCCAACCCAACCCATTCATCTTACCCCCAAGGAGACTTCCCGGGCAATACTCTCTG GCTGCGGTTGTCCTTGGCCTTGTCCAGTCTCTCAACAGGCAAAGGCAGAAGCAACTTCTCAACGAGAACA GCAATTCGGGCATCATCAAGAGCCATTACAACCGGCGGACTTTGCTAACGCCAAGTGGGCCAGAGCCTGG AGCACAAGCTGAAGGCACTGACAAATCCGATTTGCCATAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_009623 |
| Insert Size | 3750 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_009623.2, NP_033753.2 |
| RefSeq Size | 5064 bp |
| RefSeq ORF | 3750 bp |
| Locus ID | 11514 |
| UniProt ID | P97490 |
| Gene Summary | Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion (PubMed:10864938, PubMed:25403481, PubMed:10482244, PubMed:14585998, PubMed:18448650). Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation (PubMed:10482244, PubMed:14585998, PubMed:18448650, PubMed:10864938, PubMed:12441059, PubMed:20638449, PubMed:27234425, PubMed:18222416). Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment (PubMed:25403481). Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG215716 | Adcy8 (tGFP-tagged) - Mouse adenylate cyclase 8 (Adcy8), (10ug) |
CNY 14,640.00 |
|
| MR215716 | Adcy8 (Myc-DDK-tagged) - Mouse adenylate cyclase 8 (Adcy8) |
CNY 13,040.00 |
|
| MR215716L3 | Lenti ORF clone of Adcy8 (Myc-DDK-tagged) - Mouse adenylate cyclase 8 (Adcy8) |
CNY 14,350.00 |
|
| MR215716L4 | Lenti ORF clone of Adcy8 (mGFP-tagged) - Mouse adenylate cyclase 8 (Adcy8) |
CNY 14,350.00 |
