PCNA Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2G7]

Specifications

Product Data
Clone Name	OTI2G7
Applications	IF, WB
Recommend Dilution	WB 1:2000, IF 1:50
Reactivity	Human, Mouse, Rat, Monkey, Dog
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PCNA (NP_002583) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28.6 kDa
Gene Name	proliferating cell nuclear antigen
Database Link	NP_002583 Entrez Gene 18538 MouseEntrez Gene 25737 RatEntrez Gene 477166 DogEntrez Gene 718006 MonkeyEntrez Gene 5111 Human UniProt ID P12004
Background	The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Synonyms	ATLD2
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

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