BIN1 Rabbit Monoclonal Antibody [Clone ID: R07-2C1]

Specifications

Product Data
Clone Name	R07-2C1
Applications	IF, IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 ICC/IF: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human BIN1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 65 kDa; Observed MW: 45-80 kDa
Gene Name	bridging integrator 1
Database Link	Entrez Gene 274 Human UniProt ID O00499
Background	Swiss-Prot Acc.O00499.Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
Synonyms	AMPH2; amphiphysin-like; AMPHL; DKFZp547F068; MGC10367; OTTHUMP00000203785; SH3P9
Reference Data

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