PLAC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the phosphorylation site at Tyrosine 147 surrounding the epitope -EKCYEVF- of human Placenta-specific 1 protein. This sequence is derived from human origin.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~22 kDa
Gene Name	placenta specific 1
Database Link	NP_068568 Entrez Gene 10761 Human UniProt ID Q9HBJ0
Background	The PLAC1, a placenta-specific gene, which encodes a putative cell surface protein, is highly expressed in placenta, testis, and wide range of human malignancies, most frequently in breast cancer, and essentially involved in cancer cells proliferation, migration and invasion. The activation of PLAC1 is selectively controlled by ubiquitous transcription factor SP1 and positively correlated between PLAC1 and ER-alpha in breast cancer. PLAC1 is also expressed in human hepatocellular cancer tissues as well as in several other types of cancer tissues and/or tumor cell lines. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination.
Synonyms	CT92; OOSP2L
Reference Data
Protein Families	Secreted Protein

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