IQSEC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	IQSEC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human IQSEC1
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	IQSEC1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 106 kDa; Observed: 103 kDa
Gene Name	IQ motif and Sec7 domain 1
Database Link	NP_055684 Entrez Gene 9922 Human UniProt ID Q6DN90
Background	ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1). As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3). IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4).
Synonyms	NICE-4; NICE4
Reference Data

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