BTK Mouse Monoclonal Antibody [Clone ID: 7F12H4]

CAT#: TA336560

Mouse Monoclonal BTK Antibody (7F12H4)



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TA336560 is a replacement of AM06170SU-N.

CNY 5,381.00


货期*
5周

规格
    • 100 ul

Product images

经常一起买 (4)
Transient overexpression lysate of Bruton agammaglobulinemia tyrosine kinase (BTK)
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Recombinant protein of human Bruton agammaglobulinemia tyrosine kinase (BTK), 20 µg
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Recombinant protein of human Bruton agammaglobulinemia tyrosine kinase (BTK), 100 µg
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Specifications

Product Data
Clone Name 7F12H4
Applications ICC/IF, IHC, WB
Recommend Dilution Immunohistochemistry: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:200-1:1000, Western Blot: 1:500-1:2000, Immunohistochemistry-Paraffin: 1:200-1:1000
Reactivity Human, Primate
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of BTK expressed in E. coli. [UniProt# Q06187]
Formulation PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Ammonium sulfate precipitation
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 77 kDa
Gene Name Bruton tyrosine kinase
Background BTK, also known as Brutons tyrosine kinase, is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.
Synonyms AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Note This BTK (7F12H4) antibody is useful for Western blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and ELISA.
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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