JNK1 (MAPK8) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin: 1:200-1:500, Western Blot: 1:2000, ELISA: 1:100-1:2000, Immunohistochemistry: 1:200-1:500
Reactivity	C. elegans
Host	Rabbit
Clonality	Polyclonal
Immunogen	A recombinant protein made to the C-terminus (residues 228-451) of the C. elegans JNK1 alpha protein.
Formulation	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mitogen-activated protein kinase 8
Database Link	NP_002741 Entrez Gene 26419 MouseEntrez Gene 116554 RatEntrez Gene 5599 Human UniProt ID P45983
Background	The insulin signaling pathway plays a pivotal role in lifespan regulation and stress resistance in many diverse organisms. Components of the JNK (c-Jun N-terminal kinase) signaling pathway have been shown to interact with the insulin signaling pathway. The JNK family is a subgroup of the mitogen-activated protein kinase superfamily and is part of a signal transduction cascade that is activated by cytokines and by exposure to environmental stresses. Thus, JNK1 plays a role in regulating both life span and stress resistance.
Synonyms	2; JNK; JNK-46; JNK1; JNK1A2; JNK21B1; PRKM8; SAPK1; SAPK1c
Note	This JNK1 antibody is useful for ELISA, Immunohistochemistry-Paraffin and Western blot where a band can be seen at ~53kDa (alpha form) and at ~42kDa (beta form).
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase
Protein Pathways	Adipocytokine signaling pathway, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, GnRH signaling pathway, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Wnt signaling pathway

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