AIMP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2.
Formulation	AIMP2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	AIMP2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 35 kDa; Observed: 36 kDa
Gene Name	aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Database Link	NP_006294 Entrez Gene 7965 Human UniProt ID Q13155
Background	AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson’s disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).
Synonyms	JTV-1; JTV1; P38; PRO0992
Reference Data
Protein Families	Stem cell - Pluripotency

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