Glutathione Reductase (GSR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: Jurkat, Hela and A549 cells IHC: 50-200 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 274-475 amino acids of human glutathione reductase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	56 kDa
Gene Name	glutathione reductase
Database Link	NP_000628 Entrez Gene 14782 MouseEntrez Gene 116686 RatEntrez Gene 2936 Human UniProt ID P00390
Background	This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense; and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH; which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Synonyms	HEL-75
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism

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