Caldesmon (CALD1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-150 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 26-207 amino acids of human caldesmon 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caldesmon 1
Database Link	NP_149347 Entrez Gene 25687 RatEntrez Gene 800 Human UniProt ID Q05682
Background	This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin; actin; tropomyosin; myosin; and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase; and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.?
Synonyms	CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Reference Data
Protein Pathways	Vascular smooth muscle contraction

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